The preparation method comprises the following steps: sorting raw materials of high-quality oranges, soaking and cleaning, peeling, denucleating, crushing and pulping, juicing, adjusting components, adding distiller's yeast or yeast, carrying out primary fermentation, carrying out secondary fermentation, carrying out residue-liquid separation, ageing, clarifying, blending, sterilizing, filtering and filling to obtain a finished product. According to the method, the wine yield and the savoury and mellow taste are effectively improved, the fragrance is refreshing, meanwhile, the health care effect is achieved, the wine yield is effectively improved through multiple times of fermentation, rapid propagation of thalli is facilitated, the influence of infectious microbes on the fermentation effect is reduced, and the taste of the citrus wine is guaranteed. The orange wine can treat stagnation and flatulence, can treat some flatulence symptoms, and can play a role in ventilating and regulating qi and playing a role in guiding qi downward; the orange wine can play a role in promoting blood circulation and stopping bleeding, and the orange wine contains vitamin P and has the effects of dredging collaterals and promoting blood circulation; the orange wine can regulate qi to alleviate pain, also has an analgesic effect, is a natural analgesic, can be drunk for improvement, and has a very remarkable effect.