Grapefruit pericarp and pomace extractive preparation method and preparation containing extractive

A pomace extract and extract technology are applied in the field of preparation of plant active ingredients, can solve the problems of environmental pollution, excess production, slow increase in economic benefits of Changshan Huyou, etc., reduce environmental pollution, promote utilization, and broad market prospects. Effect

Inactive Publication Date: 2014-03-26
CHINA JILIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to statistics, the annual output of Changshan pomelo in Zhejiang Province is 130,000 tons. However, due to the quality of the fruit and other reasons, the economic benefits of Changshan pomelo are increasing slowly, and there is even a phenomenon of overproduction in some areas. certain environmental pollution

Method used

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  • Grapefruit pericarp and pomace extractive preparation method and preparation containing extractive
  • Grapefruit pericarp and pomace extractive preparation method and preparation containing extractive
  • Grapefruit pericarp and pomace extractive preparation method and preparation containing extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of pomelo peel pomace extract

[0024] 1) Take fresh Changshan pomelo peel and pomace, successively cut into pieces, oven-dried at 40-60°C and pulverized to obtain powder;

[0025] 2) Take the powder obtained in step 1) and heat and reflux with 95% ethanol solution for three extractions, the first time is 2 hours, the second time is 1.5 hours, the third time is 1.5 hours, and the oily extract is obtained;

[0026] 3) The oily extract obtained in step 2) is mixed with petroleum ether at a volume ratio of 1:1 for extraction, repeated 5 times, and after extraction, the lower layer extract is taken to volatilize petroleum ether to obtain the degreased extract;

[0027] 4) Take the degreased extract and use D101 macroporous resin for column chromatography, elute with ethanol with a concentration of 40-80%, collect the eluent, and spin-evaporate the eluent to obtain Changshan Huyou peel and pomace extract .

[0028]

Embodiment 2

[0029] Embodiment 2: the preparation of pomelo peel pomace extract capsule

[0030] The Changshan Huyou peel and pomace extract obtained in Example 1 was crushed through an 80 mesh sieve, mixed with starch, dextrin, and Tween-20, and the Changshan Huyou peel and pomace extract, starch, dextrin and The weight ratio of Tween-20 is 2~4:1:0.03~0.04, the soft material is made of 8% starch slurry as the binder, granulated through a 24 mesh sieve, dried at 60°C, and 0.7% After the aluminum hydroxide is mixed evenly, it is filled in an empty capsule to obtain the Changshan Huyou pericarp pomace extract capsule.

[0031]

Embodiment 3

[0032] Example 3: Determination of flavonoids and limonoids in Changshan huyou peel and pomace extract and determination of the best process

[0033] 1 Materials and methods

[0034] 1.1 Experimental materials, instruments, reagents and reagents

[0035] 1.1.1 Experimental materials

[0036] Changshan Huyou (purchased from the local fruit market in Changshan County, Zhejiang Province)

[0037] 1.1.2 Main Instruments

[0038] GZX-9140 MBE digital display blast drying oven (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory), UV-1800 ultraviolet-visible spectrophotometer (SHIMADZU CORPORATION (Shimadzu)), PL-203 electronic balance (METTLER TOLEDO (Mettler) -Toledo) Instrument (Shanghai) Co., Ltd.), HWS26 constant temperature water bath (Shanghai Yiheng Technology Co., Ltd. Shanghai Yiheng Technology Instrument Co., Ltd.), Sorvall ST 16R refrigerated centrifuge (Thermo Scientific), FiveEasy Plus pH meter (METTLER TOLEDO (Mettler-Toledo) Instrument (Shanghai) Co., L...

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Abstract

The invention discloses a grapefruit pericarp and pomace extractive preparation method and a preparation containing the extractive and belongs to the preparation method of plant active ingredients. The preparation method comprises the following steps: sequentially cutting up, drying and smashing fresh grapefruit pericarp and pomace to obtain powder; using a 95% ethanol solution to perform heating reflux on the powder for extraction so as to obtain an oily extractive; adding petroleum ether into the oily extractive for ungrease treatment so as to obtain a nonfat extractive; utilizing D101 macroporous resin to perform column chromatography on the nonfat extractive, using ethyl alcohol to perform elution, collecting the eluant, and performing rotary evaporation on the eluant to obtain the grapefruit pericarp and pomace extractive. According to the invention, the grapefruit pericarp and pomace waste is used as the raw material to establish the effective ingredient extractive technology, extract limonin and flavonoid substances, research and develop capsula capable of reducing blood fat and meet the demand of the current blood fat reduction health care product market, so that the grapefruit pericarp and pomace extractive has broad market prospects.

Description

technical field [0001] The invention belongs to a preparation method of plant active ingredients, and in particular relates to a preparation method of Changshan Huyou fruit pomace extract and a preparation containing the extract. Background technique [0002] Changshan pomelo, also known as golden pomelo, is a new species of citrus in my country that is a natural hybrid of pomelo and orange. It is native to Changshan County, Zhejiang Province, and has a cultivation history of more than 100 years. Because of its beautiful appearance, suitable size, attractive color, unique aroma, fresh and crisp taste, rich nutrition, and excellent storage and transportation resistance, it is favored by consumers. It is not only an ideal fresh fruit, but also a kind of fruit. Very good processing raw materials, high economic value, and has won many awards in national competitions, becoming my country's first high-quality citrus, known as "China's No. 1 citrus". [0003] According to statistic...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P3/06A61K131/00
Inventor 林敏任思捷张真真潘家荣张永勇
Owner CHINA JILIANG UNIV
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