Segmented and gradient functional tendon sleeve implanting device and preparation method thereof

A gradient function, segmented technology, applied in the medical field, can solve the problems of weak vascular regeneration ability, limited cell source, and unsatisfactory ACL regeneration effect, so as to maintain mechanical strength, promote ligament regeneration and remodeling, and increase cell adhesion. effect of proliferation

Pending Publication Date: 2020-01-17
SHANGHAI SIXTH PEOPLES HOSPITAL
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Problems solved by technology

Moreover, in the environment of the joint cavity, the source of cells for ligament regeneration is limited, and the ability of angiogenesis is weak, which makes the effect of ACL regeneration unsatisfactory.
However, there is curr

Method used

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  • Segmented and gradient functional tendon sleeve implanting device and preparation method thereof
  • Segmented and gradient functional tendon sleeve implanting device and preparation method thereof
  • Segmented and gradient functional tendon sleeve implanting device and preparation method thereof

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Embodiment Construction

[0031] The present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited to the following embodiments.

[0032] The preparation of segmented, gradient functionalized tendon cuff implantation device comprises the following steps:

[0033] (1) Firstly, PLA, PLCL, PPDO, PET and PHA materials are prepared by electrospinning or textile weaving methods such as figure 1 The three-dimensional scaffold structure in the form of a porous hollow cylinder structure including the bone canal and the joint cavity; as shown image 3 As shown, the cross-section of the bone canal is circular, and the concentration gradient of the inducer decreases from the outside to the inside; as Figure 4 As shown, the section of the joint cavity is porous; Figure 5 As shown, the bone tunnel is composed of interlaced warp and latitude lines; as Figure 6 As shown, the joint cavity is composed of parallel wefts.

[0034] (2) Using phys...

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Abstract

The invention discloses a segmented and gradient functional tendon sleeve implanting device and a preparation method thereof. The preparation method includes the steps: (1) firstly, a three-dimensional bracket structure containing a bone tunnel part and a joint cavity part and having a porous hollow cylindrical structure shape is prepared through an electrostatic spinning or textile weaving method; (2) surface modification is conducted on wefts of the joint cavity part through a physical or chemical method, and surface modification comprises protein and small molecular compound modification; (3) gradient modification is conducted on the bone tunnel part through a physical or chemical method, and gradient modification comprises bone material, protein and small molecular compound modification; and (4) a needle threading marker hole is reserved in the outer surface of the bone tunnel part, a traction line is arranged, and thus the segmented and gradient functional tendon sleeve implantingdevice is obtained. The segmented and gradient functional tendon sleeve implanting device can achieve a promoting enhancement effect on clinical ACL repair through autograft tendon and allogenic tendon grafts and artificial grafts and ligament regeneration and tendon-bone healing of other ligament and tendon injuries, and provide mechanical protection without forming of stress shielding.

Description

technical field [0001] The invention relates to the medical field, in particular to a segmented, gradient functionalized tendon cuff implantation device and a preparation method thereof. Background technique [0002] At present, the grafts that can be used clinically for ACL reconstruction are mainly autografts, allografts and artificial grafts. The reconstruction of ACL with autologous and allografts involves regeneration of ligaments in the joint cavity and tendon-bone healing in both ends of the bone canal. There is a period of mechanical weakness in the transformation and remodeling of allografts in vivo, and early functional exercise after ACL surgery is an important step in postoperative rehabilitation. The mechanical attenuation and functional exercise of the reconstructed ligament are contradictory. Moreover, in the environment of the joint cavity, the source of cells for ligament regeneration is limited, and the ability of angiogenesis is weak, which makes the effec...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61L27/50
CPCA61F2/0805A61L27/50A61L2400/18
Inventor 赵金忠李亚民蒋佳赵松谢国明董士奎燕晓宇朱同贺
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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