Method for preparing heparin coating by using medical accessory equipment contacting with blood

A medical aid and heparin coating technology, applied in the medical field, can solve the problems of limited application scope, unstable ionic bond, and change in the spatial structure of heparin molecules, so as to overcome the effects of coagulation and inflammatory reactions.

Inactive Publication Date: 2005-03-30
NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the instability of ionic bonds, plasma macromolecules such as albumin with affinity can combine with heparin to cause heparin molecules to fall off. At the same time, the quaternary ammonium salts and surfactants used are usually biologically toxic, which limits the Its scope of application
The covalent bond heparin binding method often requires that the surface to be bound has active groups that are prone to chemical reactions, and the selected active groups should not be easily inactivated by chemical modification during the binding process, which also limits its use. In addition, covalently bonded heparin molecules often lose their anticoagulant activity due to changes in their spatial structure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Close one end of a 25cm-long medical polyvinyl chloride pipe (inner diameter 1cm), inject 5% polyethyleneimine ethanol solution into the other end, and pour out the remaining solution after bathing in water at 37°C for 30 minutes. Repeat 3 times and dry under vacuum at room temperature.

[0026] Then pour 100ml of heparin aqueous solution with a mass fraction of 1% (pH = 1) into the pipeline, and a thin layer of white precipitates can be seen on the surface of the pipeline. After 3 minutes in a water bath at 37°C, pour out the remaining solution, and dry it under vacuum at room temperature for later use.

Embodiment 2

[0028] Close one end of a 25cm-long medical silicone rubber pipe (inner diameter 1.2cm), inject the other end with 2.5% polyethyleneimine ethanol solution containing 5% glutaraldehyde, and pour out the remaining solution after bathing in water at 37°C for 30 minutes. Repeat 3 times and dry under vacuum at room temperature.

[0029] Then pour 100ml of heparin aqueous solution with a mass fraction of 1% (pH=1) into the pipeline, bathe in water at 37°C for 3 minutes, pour out the remaining solution, and dry it under vacuum at room temperature for later use.

[0030] The present invention uses polyethyleneimine for the first time to treat the surface of medical device materials in contact with blood, and is applied to extracorporeal circulation equipment, cardiac assist equipment, and dialyzers in cardiac surgery, including oxygenators, blood reservoirs, and arterial microembolus filters. , Connecting pipelines, dialysis equipment, balloon counterpulsation, cardiac assist equipmen...

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PUM

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Abstract

A process for preparing a coated heparin layer on the surface of medical equipment, where the blood is contacted features that a polyvinylimine method is used to make said surface carry the free amino space structure and positive charges for ion-bond binding with the negative charges of heparin moleculae or a cross-linking agent is used for co-valence bond binding with aminos in heparin moleculae to fix the heparin molecular onto said surface. Its advantages are high bioactivity, biological combatibility and anti-coagulating activity, and low toxic by-effect.

Description

1. Technical field [0001] The invention belongs to the field of medical technology, and relates to a heparin coating method for improving the biological and blood compatibility of medical devices in contact with blood, in particular to a type of heparin coating method used in extracorporeal circulation, heart assist devices and dialyzers, etc. Preparation method of heparin coating for contact medical aids. 2. Background technology [0002] It has become a routine method to apply extracorporeal circulation, cardiac assist device, dialyzer and other medical devices in contact with blood to treat clinical diseases. Extracorporeal circulation and heart assist devices and dialyzers mainly include oxygenators, blood reservoirs, arterial microemboli filters, connecting pipes, dialysis pipes, balloon counterpulsation, ventricular assist devices, etc. The constituent materials mainly include chemical substances such as polyethylene, polytetrafluoroethylene, polyester, polyvinyl chlo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/10
Inventor 易定华杨剑曹瑞军刘剑段维勋刘金成
Owner NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
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