Method for preparing heparin coating by using medical accessory equipment contacting with blood

Abstract

A process for preparing a coated heparin layer on the surface of medical equipment, where the blood is contacted features that a polyvinylimine method is used to make said surface carry the free amino space structure and positive charges for ion-bond binding with the negative charges of heparin moleculae or a cross-linking agent is used for co-valence bond binding with aminos in heparin moleculae to fix the heparin molecular onto said surface. Its advantages are high bioactivity, biological combatibility and anti-coagulating activity, and low toxic by-effect.

Description

1. Technical field [0001] The invention belongs to the field of medical technology, and relates to a heparin coating method for improving the biological and blood compatibility of medical devices in contact with blood, in particular to a type of heparin coating method used in extracorporeal circulation, heart assist devices and dialyzers, etc. Preparation method of heparin coating for contact medical aids. 2. Background technology [0002] It has become a routine method to apply extracorporeal circulation, cardiac assist device, dialyzer and other medical devices in contact with blood to treat clinical diseases. Extracorporeal circulation and heart assist devices and dialyzers mainly include oxygenators, blood reservoirs, arterial microemboli filters, connecting pipes, dialysis pipes, balloon counterpulsation, ventricular assist devices, etc. The constituent materials mainly include chemical substances such as polyethylene, polytetrafluoroethylene, polyester, polyvinyl chlo...

AI Technical Summary

Problems solved by technology

However, due to the instability of ionic bonds, plasma macromolecules such as albumin with affinity can combine with heparin to cause heparin molecules to fall off. At the same time, the quaternary ammonium salts and surfactants used are usually biologically toxic, which limits the Its scope of application

The covalent bond heparin binding method often requires that the surface to be bound has active groups that are prone to chemical reactions, and the selected active groups should not be easily inactivated by chemical modification during the binding process, which also limits its use. In addition, covalently bonded heparin molecules often lose their anticoagulant activity due to changes in their spatial structure