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Anticoagulant coating and preparation method thereof

An anti-coagulation and coating technology, applied in the field of anti-coagulation coating and its preparation, can solve the problems of reduced anti-coagulation effect, restricted movement, monopoly, etc., and achieves improved blood stability, increased stability, and good application. Potential effect

Inactive Publication Date: 2021-08-27
GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, foreign commercialized anticoagulant coatings have developed to the third generation, but there are no domestically produced products in the domestic market. Therefore, the prices of related medical device products have remained high and are monopolized by foreign manufacturers.
[0004] At present, the preparation of anticoagulant coatings mainly has the following difficulties: 1. The biological materials that require surface treatment of anticoagulant coatings involve various materials such as metals and non-metals. Currently, commercialized anticoagulant coatings exist 2. The traditional covalent heparin anticoagulant coating is limited in the movement of the active groups on the surface of the material, resulting in a greatly reduced anticoagulant effect; 3. Traditional anticoagulant coatings The blood stability of the coagulation coating is poor, and the anticoagulant drug molecules are easy to fall off

Method used

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  • Anticoagulant coating and preparation method thereof
  • Anticoagulant coating and preparation method thereof

Examples

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Effect test

Embodiment 1

[0051] An embodiment of the anticoagulant coating of the present invention, the anticoagulant coating described in this embodiment is polydopamine-polylysine-(No. 1 heparin-protein complex) coating, the structure is as attached figure 1 As shown, it includes substrate 1, polydopamine coating 2, polyamino compound connecting layer 3, and heparin-protein functional layer 4 from bottom to top, and the layers are connected by covalent bonds; the preparation process is as shown in the attached figure 2 As shown, the details are as follows:

[0052] Step 1. Weigh 500 mg of dopamine hydrochloride and dissolve it in 500 ml of deionized water, adjust the pH to 8.5, then add 500 mg of sodium periodate to dissolve, and prepare coating solution 1. Use a peristaltic pump to suck the coating liquid 1 into the circulating coating system, use the PVC pipe to be coated as the circulation channel pipeline, and put the parts to be coated of other materials to be coated into the liquid accumulat...

Embodiment 2

[0057] An embodiment of the anticoagulant coating of the present invention, the anticoagulant coating described in this embodiment is polydopamine-polyethyleneimine-(No. 1 heparin-protein complex) coating, and the structure is as attached figure 1 As shown, it includes substrate 1, polydopamine coating 2, polyamino compound connecting layer 3, and heparin-protein functional layer 4 from bottom to top, and the layers are connected by covalent bonds; the preparation process is as shown in the attached figure 2 As shown, the details are as follows:

[0058] Step 1. Weigh 50 mg of dopamine hydrochloride and dissolve it in 500 ml of deionized water, adjust the pH to 7, then add 50 mg of sodium periodate to dissolve, and prepare coating solution 1. Use a peristaltic pump to suck the coating liquid 1 into the circulating coating system, use the PVC pipe to be coated as the circulation channel pipeline, and put the parts to be coated of other materials to be coated into the liquid ac...

Embodiment 3

[0063] An embodiment of the anticoagulant coating of the present invention, the anticoagulant coating in this embodiment is polydopamine-polyethyleneimine-(No. 2 heparin-protein complex), and the structure is as attached figure 1 As shown, it includes substrate 1, polydopamine coating 2, polyamino compound connecting layer 3, and heparin-protein functional layer 4 from bottom to top, and the layers are connected by covalent bonds; the preparation process is as shown in the attached figure 2 As shown, the details are as follows:

[0064] Step 1. Weigh 5000 mg of dopamine hydrochloride and dissolve it in 500 ml of deionized water, adjust the pH to 10, then add 5000 mg of sodium periodate to dissolve, and prepare coating solution 1. Use a peristaltic pump to suck the coating liquid 1 into the circulating coating system, use the PVC pipe to be coated as the circulation channel pipeline, and put the parts to be coated of other materials to be coated into the liquid accumulation bo...

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Abstract

The invention discloses an anticoagulant coating. The anticoagulant coating sequentially comprises a base material, a polydopamine coating, a multi-amino compound connecting layer and a heparin-protein functional layer from bottom to top, and all the layers are connected through covalent bonds. According to the anticoagulant coating, heparin molecules are modified through protein, and the problem that an existing covalent bonding method heparin coating is poor in anticoagulant effect is solved; a bottom layer and a functional layer are connected through a connecting layer, so the problem that an existing coating is poor in blood stability is solved; and a solution flowing method is used for coating a polydopamine base coat, and the problem that an existing dip-coating method is not uniform in coating is solved. Meanwhile, the invention further discloses a preparation method of the anticoagulant coating. The preparation process of the anticoagulant coating is simple to operate, the whole coating time can be controlled within 8 hours, and the anticoagulant coating has good application potential.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an anticoagulant coating with strong substrate adaptability and a preparation method thereof. Background technique [0002] With the advancement of science and technology, medical devices are more and more widely used in medical behavior, especially in improving human health and preventing diseases. There are various materials for preparing medical devices, covering non-metal, metal materials and composite materials, etc.; for medical devices that are in direct contact with the human body, the biocompatibility requirements of the materials are relatively high. For example, blood contact materials and intravascular implanted medical devices, such devices are in direct contact with blood, and blood components are complex and diverse, which are easy to interact with materials and cause a series of side effects and clinical complications such as hemolysis and coagulation. Therefo...

Claims

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Application Information

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IPC IPC(8): A61L33/06A61L33/10A61L33/12A61L33/00
CPCA61L33/068A61L33/08A61L33/128A61L33/0029A61L2300/42A61L2300/606A61L2420/02A61L2420/08A61L2420/06A61L2300/236A61L2300/252
Inventor 姜涛黄海康王瑞彬林雪媛
Owner GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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