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Modified polymeric membrane material and preparation method thereof

A polymer film and modification technology, applied in the types of packaging items, special packaging items, packaging, etc., can solve the problems of limited amino or carboxyl group content on the surface of the film, low heparin grafting efficiency, affecting the mechanical properties of the film, etc. Anticoagulant properties, good market application prospects, and the effect of reducing platelet adhesion

Pending Publication Date: 2022-01-04
NINGBO JENSCARE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of amino or carboxyl groups on the surface of the membrane formed by this method is limited, resulting in low heparin grafting efficiency; at the same time, this method of dopamine adhesion may affect the mechanical properties of the membrane

Method used

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  • Modified polymeric membrane material and preparation method thereof
  • Modified polymeric membrane material and preparation method thereof
  • Modified polymeric membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] In this embodiment, the polymer membrane material is polyurethane membrane.

[0050] In this embodiment, the preparation steps of the unmodified polyurethane film include: dissolving the polyurethane pellets in dimethylacetamide to prepare a polyurethane solution with a mass concentration of 12%, pouring the polyurethane solution into a polytetrafluoroethylene mold, and evenly spreading Open it, put it into a vacuum drying oven, dry it in vacuum at 50°C for 24 hours, take out the mold, wait for the temperature to drop to room temperature, add purified water, take out the film, wash it, and dry it at room temperature or in vacuum for later use to obtain a flat polyurethane film, and put the polyurethane The membranes were divided into two groups, the control group and the test group, with 3 pieces in each group; among them,

[0051] Control group: the flat polyurethane film was washed in PBS solution and cut into 10*10mm sheets for contact angle and platelet adhesion tes...

Embodiment 2

[0057] The difference with Example 1 is:

[0058] In the present embodiment, the preparation steps of the unmodified polyurethane film include: dissolving the polyurethane pellets in dioxane to prepare a polyurethane solution with a mass concentration of 15%, pouring the polyurethane solution into a polytetrafluoroethylene mold, and spreading it evenly , put it into a vacuum drying oven, dry it in vacuum at 50°C for 24 hours, take out the mold, wait until the temperature drops to room temperature, add purified water, take out the film, wash it, dry it at room temperature or in vacuum for later use, obtain a flat polyurethane film, and put the polyurethane film Divided into two groups of control group and test group, each group has 3 tablets;

[0059] Control group: the flat polyurethane film was washed in PBS solution and cut into 10*10mm sheets for contact angle and platelet adhesion tests;

[0060] Test group: the first step, prepare 100ml of pretreatment solution containin...

Embodiment 3

[0064] The difference with Example 1 is:

[0065] In this embodiment, the preparation steps of the unmodified polyurethane film include: dissolving the polyurethane pellets in a solvent of tetrahydrofuran / dioxane=1:1 to prepare a polyurethane solution with a mass concentration of 15%, pouring the polyurethane solution into Spread the polytetrafluoroethylene mold evenly, put it in a vacuum drying oven, and dry it in vacuum at 50°C for 24 hours, then take out the mold, wait until the temperature drops to room temperature, add purified water, take out the film, wash it, and dry it at room temperature or in vacuum for later use. Smooth polyurethane film, and polyurethane film is divided into control group and test group two groups, every group 3; Wherein,

[0066] Control group: the flat polyurethane film was washed in PBS solution and cut into 10*10mm sheets for contact angle and platelet adhesion tests;

[0067] Test group: first step, prepare 100ml of pretreatment solution con...

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Abstract

The invention relates to a modified polymeric membrane material and a preparation method thereof. The modified polymeric membrane material is mainly characterized in that the surface of the polymeric membrane material is grafted with two coatings having a substance with anticoagulant action, namely a phosphorylcholine zwitterion coating and a heparin coating. The preparation method of the coating comprises the following steps: step 1, grafting the surface of the polymeric membrane material with phosphorylcholine and acrylamide copolymer; step 2, putting the treated polymeric membrane material into a cleaning solution for cleaning, soaking and drying; and step 3, reacting residual amino groups grafted on the polymeric membrane material dried in step 2 with a EDC and NHS-activated heparin solution obtain the modified polymeric membrane material with the surface compounded and grafted with the phosphorylcholine zwitterion coating and the heparin coating. The preparation method can prepare the modified polymeric membrane material which is good in mechanical property, good in hydrophilicity and long-acting in anticoagulation. The prepared heparin coating is uniform, the heparin grafting amount is high and can reach 6.3 [mu]g / cm<2>, and the heparin coating has a good market prospect.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a modified polymer membrane material and a preparation method thereof. Background technique [0002] Polymer materials are widely used in materials in contact with body fluids or blood because of their good mechanical properties, wear resistance and processing properties. As one of the important medical materials, polyurethane is widely used in artificial heart and artificial blood vessel. Polyurethane biomaterials can currently be used in medical devices such as catheters for interventional operations, ureteral catheters, wound dressings, artificial hearts, artificial heart valves, and intravenous infusion ports. [0003] Medical polyurethane materials can be divided into polyester polyurethane, polyether polyurethane and polycarbonate polyurethane according to the chemical composition. Polyester polyurethane is a polyurethane material synthesized based on polyester...

Claims

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Application Information

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IPC IPC(8): A61L33/06A61L33/00C08J5/18C08J7/16C08J7/12C08L75/04
CPCA61L33/068A61L33/0011A61L33/0041C08J5/18C08J7/16C08J7/12A61L2300/236A61L2300/216A61L2300/42A61L2300/602C08J2375/04C08L75/04
Inventor 胡艳飞刘欢胡蝶陈金婷
Owner NINGBO JENSCARE BIOTECHNOLOGY CO LTD
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