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Alkene-functionalized heparin compound and application thereof

A compound and alkene-functional technology, applied in the field of alkene-functionalized heparin compounds, can solve the problems of limited wide application, narrow material range, complicated pretreatment process, etc., and achieve the effects of simple process, firm bonding and wide application range of materials

Inactive Publication Date: 2021-01-15
北京米道斯医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] All of the above heparin coatings require specific properties on the surface of the material itself or after treatment in order to be effectively combined with the coating, which not only requires a complicated pre-treatment process, but also has a narrow range of materials to choose from, limiting its wide application in medical

Method used

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  • Alkene-functionalized heparin compound and application thereof
  • Alkene-functionalized heparin compound and application thereof
  • Alkene-functionalized heparin compound and application thereof

Examples

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preparation example Construction

[0027] Preparation of ethylenically functionalized heparin compound: the heparin compound is obtained by reacting heparin with an unsaturated monomer with isocyanate group, the reaction occurs between the isocyanate group of the unsaturated monomer with isocyanate group and the hydroxyl group of the heparin molecule, in order To ensure the complete reaction of heparin molecules, excess isocyanate groups should be made, that is, the molar ratio of isocyanate group unsaturated monomers to heparin is greater than 1:1; the reaction temperature is 50°C-90°C; the reaction time is 4-6 hours. To obtain ene-functionalized heparin, the specific reaction formula is as follows:

[0028]

[0029] Where: R is H or -CH3

[0030] n is an integer between 2-10

[0031] Preparation of the heparin coating solution: the olefin-functionalized heparin compound is mixed with a photoinitiator, a solvent, and a functionalized monomer, oligomer or polymer to prepare a solution, and the olefin-functi...

Embodiment 1-5

[0037] Preparation of ene-functionalized heparin compounds: Dissolve 15g of heparin in 100mL of anhydrous THF, place in a three-necked bottle, stir evenly, and pour into dry N 2 , heated to 60°C; 0.3g of isocyanate ethyl acrylate was dissolved in 20mL of anhydrous THF, placed in a dropping funnel, slowly added dropwise into a three-necked bottle, and the dropwise addition was completed in 30 minutes, and continued to maintain the temperature for 4 hours. Precipitate twice with anhydrous ether and dry in a vacuum oven for 24 hours. An ene-functionalized heparin compound is obtained.

[0038] Preparation of heparin coating solution: In a 200mL brown flask, add ethylenically functionalized heparin, photoinitiator, solvent and functionalized monomer, oligomer or polymer respectively according to the formula shown in Table 1 below, room temperature Stir until the polymer is completely dissolved and a homogeneous solution is formed.

[0039] Table 1 Formulas of different heparin c...

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Abstract

The invention provides an alkene-functionalized heparin compound and application thereof. According to the invention, an isocyanate group of an unsaturated monomer with an isocyanate group reacts witha hydroxyl group in heparin to obtain the alkene-functionalized heparin compound; and the alkene-functionalized heparin compound can be obtained under mild reaction conditions and does not influencethe activity of the heparin. Meanwhile, the alkene-functionalized heparin compound is mixed with a photoinitiator, a solvent and the like to form a heparin coating solution, alkene functional groups participate in a photo-initiated free radical polymerization reaction to form a cross-linked skeleton, and heparin molecules are arranged on the surface of the cross-linked skeleton, so a heparin coating obtained by using the method does not need the surface of a substrate material to have a special structure or special performance and does not need complex pretreatment; and the application range of the material is wide, and a process is simple.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a heparin anticoagulant coating on the surface of a medical device, and more specifically relates to an ene-functionalized heparin compound and an application thereof. Background technique [0002] As a major anticoagulant and antithrombotic drug, heparin has been used clinically for nearly 80 years, and there is no substitute so far. Rich application experience. Heparin was first discovered in the liver and got its name. It is a mucopolysaccharide sulfate composed of glucosamine, L-iduroside, N-acetylglucosamine and D-glucuronic acid alternately. It has an average molecular weight of 15KD and is strongly acidic. It also exists in lungs, blood vessel walls, intestinal mucosa and other tissues, and is a natural anticoagulant substance in animals. Naturally present in mast cells, it is now mainly extracted from bovine lung or pig small intestinal mucosa. As an an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10A61L31/10A61L31/16
CPCC08B37/0075A61L31/10A61L31/16A61L2300/42A61L2300/606A61L2300/236
Inventor 厉蕙蕙陈雪生郑腾
Owner 北京米道斯医疗器械有限公司
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