A kind of heparin-coated drainage tube for reducing intraocular pressure and preparation method thereof

Abstract

The invention belongs to the technical field of ophthalmic medical biological materials, and provides a heparin-coated drainage tube for reducing intraocular pressure and a preparation method thereof. It is suitable for minimally invasive implantation, not only has good biocompatibility and high safety, but also has good flexibility and compliance, and the heparin coating on its surface can effectively prevent tissue fluid or blood from forming scars on its surface or blood clots, further reducing the possible complications of surgery.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medical biological materials, in particular to a heparin-coated drainage tube for reducing intraocular pressure and a preparation method thereof. Background technique [0002] Glaucoma is an irreversible blinding eye disease, characterized by optic disc damage, decreased visual acuity and related visual field defects. The main factors are pathological elevated intraocular pressure and insufficient blood supply to the optic nerve, but the factors that induce glaucoma are complex. . At present, the main clinical treatment method is to reduce intraocular pressure. The intraocular pressure reduction treatment of early glaucoma is mainly carried out by means of drugs, but long-term medication of patients will cause drug resistance, and most patients are already in the middle and late stages when they visit a doctor, and drug therapy is used. The demand cannot be met, so surgery is required for trea...

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Problems solved by technology

Nevertheless, its chitosan material itself is positively charged, and it is easy to cause reactions such as allergy, inflammation, and blood coagulation when implanted in the eye and in contact with tissues or blood; 100-500 μm, outer diameter 300-1000 μm, using gelatin or its derivatives as the matrix, through the steps of curing, cross-linking, drying and other steps through its self-made gel tube preparation device, it has good biocompatibility and controllable performance However, studies have pointed out that gelatin can promote the aggregation of platelets, increase the release of platelet activating factors PF4, P-selectin and TXB2, stimulate the endogenous coagulation pathway and play a role in rapid hemostasis. Therefore, gelatin-based glaucoma drainage The tube still cannot avoid the blood coagulation reaction when it comes into contact with intraocular tissue or blood; Chinese patent CN111467581 A discloses a glaucoma drainage tube made of acrylic material, with an inner diameter of 35-75 μm and an outer diameter of 300-400 μm. - Pulling and dipping in the gel solution, and after steps such as cross-linking, curing, removing impurities, drying, and demolding, the drainage tube is finally obtained, which has good flexibility and compliance. However, the free radicals used in the preparation process Toxic small molecules such as initiators and cross-linking agents cannot be completely removed, and there are still safety risks in long-term application to the human body. At the same time, it is still inevitable to cause inflammation, coagulation, etc.

Here, none of these patents gives a solution or how to reduce adverse reactions such as allergies, inflammation or blood coagulation that may occur when the glaucoma drainage tube is implanted in the eye and comes into contact with tissue or blood, or other complications caused by it

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