Manufacturing method of temperature-sensitive hydrogel compound coating intravascular stent

A temperature-sensitive hydrogel and vascular stent technology, which is applied in the field of preparation of temperature-sensitive hydrogel composite coating vascular stents, can solve problems such as biocompatibility effects, and achieve the effects of reducing hemolysis rate, preventing restenosis, and prolonging dynamic coagulation time

Inactive Publication Date: 2014-04-02
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chitosan is a natural cationic polymer that can promote the proliferation of vascular endothelial cells and is widely used in the coating research of cardiovascular stents, such as: chitosan/heparin composite coating film, silk fibroin peptide/chitosan Polymer Coating, Polyurethane/(Carboxymethyl Chitosan/Chitosan) n Composite coatings, etc., but chitosan can only be dissolved in acidic solutions, which has a certain impact on its biocompatibility
In 20

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1): The bare metal vascular stent was ultrasonically cleaned in acetone, absolute ethanol and deionized water for 30 minutes respectively to remove surface residues, and vacuum dried for 30 minutes; then the bare metal vascular stent was placed in 5 M NaOH solution for 60 minutes. Soak at ℃ for 24 h, take it out, rinse it with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 30 min, and vacuum dry for 30 min.

[0024] (2): Dip the bare metal stent obtained in (1) into the rapamycin drug solution, and the drug coating amount is 50 μg / cm 2 , placed at room temperature for 30 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0025] (3): Immerse the metal vascular stent obtained in (2) in 0.1% (W / V) hydroxybutyl chitosan aqueous solution (the gelation temperature of hydroxybutyl chitosan is 15°C, and the degree of substitution of hydroxybutyl chitosan is 2.0), placed at room...

Embodiment 2

[0028] (1): The bare metal vascular stent was ultrasonically cleaned in acetone, absolute ethanol and deionized water for 60 minutes respectively to remove surface residues, and then vacuum dried for 30 minutes; then the bare metal vascular stent was placed in 3M NaOH solution at 70 °C Soak for 48 hours, take it out, rinse with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 60 minutes, and vacuum dry for 30 minutes.

[0029] (2): Immerse the metal vascular stent obtained in (1) in the paclitaxel drug solution, and the drug coating amount is 150 μg / cm 2 , placed at room temperature for 60 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0030] (3): Immerse the drug-coated metal vascular stent obtained in (2) in 1% (W / V) hydroxybutyl chitosan aqueous solution (the gelation temperature of hydroxybutyl chitosan is 30°C, hydroxybutyl chitosan The degree of substitution is 0.5), pl...

Embodiment 3

[0033] (1): First, the bare metal stent was ultrasonically cleaned in acetone, absolute ethanol, and deionized water for 40 minutes to remove surface residues, and vacuum dried for 30 minutes; then the bare metal stent was placed in 3.5M NaOH solution, Soak at 40 °C for 72 h, take it out, rinse with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 40 min, and vacuum dry for 30 min.

[0034] (2): The metal stent obtained in (1) was immersed in the rapamycin drug solution, and the drug coating amount was 150 μg / cm 2 , placed at room temperature for 50 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0035] (3): Immerse the drug-coated metal stent obtained in (2) in 0.3% (W / V) aqueous solution of hydroxybutyl chitosan (the gelation temperature of hydroxybutyl chitosan is 21°C, hydroxybutyl chitosan The degree of substitution is 1.1), placed at room temperature for 40 min, dried in...

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Abstract

The invention relates to a manufacturing method of a temperature-sensitive hydrogel compound coating intravascular stent. The method comprises the steps of surface alkalization treatment of a bare metal intravascular stent, medicament coating, hydroxybutyl chitosan coating, heparin coating and the like, so that an intelligent change effect from dissolving to gelling of a hydroxybutyl chitosan coating material is achieved. The manufactured temperature-sensitive hydrogel compound coating intravascular stent has high biocompatibility and biodegradability, is resistant to erosion, and has a more proper mechanical strength to endangium. A formed porous aqueous structure can realize controlled release of coated clinical treatment medicaments such as rapamycin, paclitaxel and the like, inhibit excessive proliferation of smooth muscle cells, accelerate endothelialization and prevent thrombosis and restenosis. A technology applied in the method is the combination and breakthrough of a drug loading technology and a temperature-sensitive hydrogel technology on the aspect of the research of stent surface coating materials, and the medical problem of restenosis after the placement of the stent is solved; the stent can become an ideal cardiovascular functional interface coating material, and has important theoretical significance and application value.

Description

technical field [0001] The invention relates to a method for preparing a bracket. In particular, it relates to a method for preparing a temperature-sensitive hydrogel composite coating vascular stent. Background technique [0002] Cardiovascular disease is one of the biggest killers of human health. At present, the main clinical treatment method is percutaneous coronary intervention. In this treatment method, a vascular stent needs to be placed in the blood vessel to help maintain the smooth blood flow in the blood vessel. Bare metal stents have a very good initial clinical effect, but according to statistics, 20-30% of patients will experience arterial restenosis after surgery, which is caused by in-stent restenosis. Due to the limitation of the metal material itself, after the implantation of the stent, the balloon expansion will cause damage to the intima of the vessel, which in turn will cause excessive proliferation of smooth muscle cells, which is the direct cause of ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16
Inventor 安毅李健李丹
Owner QINGDAO UNIV
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