Manufacturing method of temperature-sensitive hydrogel compound coating intravascular stent

Abstract

The invention relates to a manufacturing method of a temperature-sensitive hydrogel compound coating intravascular stent. The method comprises the steps of surface alkalization treatment of a bare metal intravascular stent, medicament coating, hydroxybutyl chitosan coating, heparin coating and the like, so that an intelligent change effect from dissolving to gelling of a hydroxybutyl chitosan coating material is achieved. The manufactured temperature-sensitive hydrogel compound coating intravascular stent has high biocompatibility and biodegradability, is resistant to erosion, and has a more proper mechanical strength to endangium. A formed porous aqueous structure can realize controlled release of coated clinical treatment medicaments such as rapamycin, paclitaxel and the like, inhibit excessive proliferation of smooth muscle cells, accelerate endothelialization and prevent thrombosis and restenosis. A technology applied in the method is the combination and breakthrough of a drug loading technology and a temperature-sensitive hydrogel technology on the aspect of the research of stent surface coating materials, and the medical problem of restenosis after the placement of the stent is solved; the stent can become an ideal cardiovascular functional interface coating material, and has important theoretical significance and application value.

Description

technical field [0001] The invention relates to a method for preparing a bracket. In particular, it relates to a method for preparing a temperature-sensitive hydrogel composite coating vascular stent. Background technique [0002] Cardiovascular disease is one of the biggest killers of human health. At present, the main clinical treatment method is percutaneous coronary intervention. In this treatment method, a vascular stent needs to be placed in the blood vessel to help maintain the smooth blood flow in the blood vessel. Bare metal stents have a very good initial clinical effect, but according to statistics, 20-30% of patients will experience arterial restenosis after surgery, which is caused by in-stent restenosis. Due to the limitation of the metal material itself, after the implantation of the stent, the balloon expansion will cause damage to the intima of the vessel, which in turn will cause excessive proliferation of smooth muscle cells, which is the direct cause of ...

AI Technical Summary

Problems solved by technology

[0004] Chitosan is a natural cationic polymer that can promote the proliferation of vascular endothelial cells and is widely used in the coating research of cardiovascular stents, such as: chitosan / heparin composite coating film, silk fibroin peptide / chitosan Polymer Coating, Polyurethane / (Carboxymethyl Chitosan / Chitosan) n Composite coatings, etc., but chitosan can only be dissolved in acidic solutions, which has a certain impact on its biocompatibility

In 2007, Zhang Shixuan and others used the CD133 antibody to specifically and rapidly capture vascular endothelial progenitor cells in peripheral blood, and used chitosan and acidic aminoglycoglycan materials for the coating of metal vascular stents to prepare aminoglycoglycans. Sugar-loaded CD133 antibody-coated metal vascular stent, and obtained a Chinese invention patent (zl200710157449.9) in June 2010, but this type of product has not yet been applied clinically