Artificial aqueous humor micro-drainage tube with drug sustained-release function and preparation method

Abstract

The invention relates to the technical field of ophthalmic medical biological materials, and provides an artificial aqueous humor micro-drainage tube with drug sustained-release function and a preparation method. Design and femtosecond laser technology, make holes on the drug-loaded microdrainage tube substrate, and covalently graft heparin coating on the surface of the substrate through grafting coupling technology, which is suitable for minimally invasive implantation, not only has good biocompatibility, It has high safety, and has good flexibility and compliance. The arrayed microporous structure of the tube wall can effectively conduct aqueous humor flow, while avoiding the failure of the device due to channel blockage, and the heparin coating on its surface can effectively prevent tissue fluid or blood. A scar or thrombus is formed on its surface, and the micro-drainage tube is loaded with therapeutic drugs, which can inhibit inflammation, allergy, immunity and other reactions of surrounding tissues after slow release.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medical biological materials, in particular to a preparation method of an artificial aqueous humor micro-drainage tube with a drug sustained release function. Background technique [0002] Glaucoma is an irreversible blinding eye disease, which is characterized by optic disc damage, decreased visual acuity and related visual field defects. The main factors are pathological intraocular pressure increase and optic nerve insufficiency, but the factors that induce glaucoma are complex. . At present, the main clinical treatment method is to reduce intraocular pressure. The intraocular pressure reduction treatment of early glaucoma is mainly carried out by means of drugs, but long-term medication of patients will cause drug resistance, and most patients are already in the middle and late stages when they visit a doctor, and drug therapy is used. The demand cannot be met, so surgery is required for t...

AI Technical Summary

Problems solved by technology

In filtering surgery, trabeculectomy is still the main method of diagnosis and treatment to control the progress of glaucoma in my country at present stage, but there are various complications such as early shallow anterior chamber, hyphema, filtering bleb wrapped , choroidal detachment or delayed choroidal hemorrhage, etc., and the fibrosis and scarring of the filtering bleb will further lead to the failure of the operation

[0003] In recent years, various aqueous humor drainage implants have been developed for the treatment of glaucoma, and have achieved good results, but there are still various problems, such as relatively rigid structure, unsatisfactory biocompatibility, implants Strong inflammatory reaction and tissue hyperplasia in the surrounding tissue, which may even lead to implant displacement and blockage, resulting in device failure requiring secondary surgery, etc.

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