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Double-layered bone repairing membrane material and preparation method thereof

A technology of bone repair and membrane materials, applied in the preparation of double-layer bone repair membrane materials, double-layer bone repair membrane materials and their preparation fields, can solve the problems of induced bone regeneration

Inactive Publication Date: 2017-07-25
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioglass material itself is hard and brittle, so it is not suitable as a scaffold to induce bone regeneration independently

Method used

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  • Double-layered bone repairing membrane material and preparation method thereof
  • Double-layered bone repairing membrane material and preparation method thereof
  • Double-layered bone repairing membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Take 4g of polycaprolactone, add it to 20mL of trifluoroethanol solvent, and let it stand in an oven for 1h to obtain a solution A with a polycaprolactone mass concentration of 0.2g / mL;

[0036] (2) Add 4 g of gelatin to solution A, and magnetically stir at room temperature for 12 hours to obtain solution B. The mass ratio of polycaprolactone to gelatin in solution B is 50 / 50;

[0037] (3) Add 0.08g of antibacterial drug ciprofloxacin to solution B, and magnetically stir at room temperature for 6h to obtain solution C. In solution C, the ratio of ciprofloxacin to polycaprolactone and the total mass of gelatin is 1 / 100;

[0038] (4) Take 7.2 g of polycaprolactone, add it to 20 mL of trifluoroethanol solvent, and let it stand in an oven for 1 hour to obtain a solution D with a polycaprolactone mass concentration of 0.36 / mL;

[0039] (5) Add 0.8 g of gelatin to solution D, and magnetically stir at room temperature for 12 hours to obtain solution E. The mass ratio of po...

Embodiment 2

[0045] (1) Take 0.8 g of polycaprolactone, add it to 20 mL of trifluoroethanol solvent, and let it stand in an oven for 1 hour to obtain a solution A with a polycaprolactone mass concentration of 0.04 g / mL;

[0046] (2) Add 7.2 g of gelatin to solution A, and magnetically stir at room temperature for 12 hours to obtain solution B. The mass ratio of polycaprolactone to gelatin in solution B is 10 / 90;

[0047] (3) Add 2.4g of antibacterial drug ciprofloxacin to solution B, and magnetically stir at room temperature for 6h to obtain solution C. In solution C, the ratio of ciprofloxacin to polycaprolactone and the total mass of gelatin is 30 / 100;

[0048] (4) Take 4 g of polycaprolactone, add it to 20 mL of trifluoroethanol solvent, and let it stand in an oven for 1 hour to obtain a solution D with a polycaprolactone mass concentration of 0.2 / mL;

[0049] (5) Add 4 g of gelatin to solution D, stir magnetically at room temperature for 12 hours to obtain solution E, the mass ratio of...

Embodiment 3

[0055] (1) Take 0.8 g of polycaprolactone, add it to 20 mL of trifluoroethanol solvent, and let it stand in an oven for 1 hour to obtain a solution A with a polycaprolactone mass concentration of 0.04 g / mL;

[0056] (2) Add 7.2 g of gelatin to solution A, and magnetically stir at room temperature for 12 hours to obtain solution B. The mass ratio of polycaprolactone to gelatin in solution B is 10 / 90;

[0057] (3) Add 0.08g of antibacterial drug ciprofloxacin to solution B, and magnetically stir at room temperature for 6h to obtain solution C. In solution C, the ratio of ciprofloxacin to polycaprolactone and the total mass of gelatin is 1 / 100;

[0058] (4) Take 7.2 g of polycaprolactone, add it to 20 mL of trifluoroethanol solvent, and let it stand in an oven for 1 hour to obtain a solution D with a polycaprolactone mass concentration of 0.36 / mL;

[0059] (5) Add 0.8 g of gelatin to solution D, and magnetically stir at room temperature for 12 hours to obtain solution E. The mass...

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Abstract

The invention provides a double-layered bone repairing membrane material and a preparation method thereof and in particular provides a bone repairing membrane material with antibacterial and inflammation-diminishing and bone promotion functions and belongs to the field of biological materials. The material takes biodegradable aliphatic polyester with biocompatibility and natural polymers as main raw materials and is prepared by adopting an electrostatic spinning method. The material has a double-layered membrane structure and comprises an outer layer added with an antibacterial drug and an inner layer added with a bone promotion substance. The material provided by the invention has excellent biocompatibility and a controllable and long-period medicine releasing performance; meanwhile, an outer-layer membrane of the double-layered membrane structure can be used for inhibiting bacterial infection and inflammation, which are easily caused after bone defects occur, and preventing bacteria from entering defected parts; an inner-layer membrane can be used for promoting the repairing of the bone defects. The material can be used for realizing controllable in-vivo degradation according to requirements and the material does not need to be taken out by a second surgery.

Description

technical field [0001] The invention relates to a preparation method of a double-layer bone repair membrane material, which belongs to the field of biological materials, and in particular to an outer layer membrane with fibers formed from degradable aliphatic polyester as the main matrix material and loaded with antibacterial drugs, and a loaded facilitator The invention discloses a double-layer bone repair membrane material composed of an inner layer membrane of bone substance and a preparation method thereof. Background technique [0002] Bone defect is a very common clinical trauma, and the bone repair process is very long, which mainly includes the hematoma and inflammation phase, the initial callus reaction phase, the cartilage formation phase, and the bone formation and remodeling phase. In the process of bone repair, cells secrete a variety of growth factors to play a role in different timing to ensure the repair of bone defects. [0003] Clinically, when a bone defe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/54A61L27/18A61L27/22A61L27/20D04H1/728D01D5/00D01F8/14D01F8/02D01F1/10
CPCA61L27/58A61L27/18A61L27/20A61L27/222A61L27/54A61L27/56A61L2300/10A61L2300/112A61L2300/216A61L2300/406A61L2300/412A61L2300/61A61L2430/02C08L89/00D01D5/0007D01D5/0076D01F1/10D01F1/103D01F8/02D01F8/14D04H1/728C08L67/04C08L5/08
Inventor 张立群池骋宫敏石锐麻文伯
Owner BEIJING UNIV OF CHEM TECH
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