Preparation method for molecularly imprinted polymer microballoon with hydrophilic high-molecular brush

A hydrophilic polymer and molecular imprinting technology, which is applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problem that the brush density of hydrophilic polymers cannot be obtained and is difficult to obtain Problems such as MIP microspheres and complex polymerization systems

Active Publication Date: 2015-02-25
NANKAI UNIV
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  • Summary
  • Abstract
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Problems solved by technology

The "one-step method" must directly add a hydrophilic macromolecular chain transfer agent to the molecularly imprinted polymerization system, which will adversely affect the self-assembly between functional monomers and template molecules
In addition, the one-step polymerization system is complicated, so that the density of the hydrophilic polymer brushes on the surface of the obtained MIP microspheres cannot be obtained, thus limiting the structural characterization of the product; and the "two-step method" approach to prepare the surface with hydrophilic polymer brushes In the case of MIP microspheres, the molecular weight of the hydrophilic polymer brushes grafted on the surface is greatly affected by the reaction conditions, and it is difficult to obtain MIP microspheres with the same molecular weight hydrophilic polymer brushes during repeated production, which will greatly Affect the stability of product performance
In addition, this method also has the difficulty that the molecular weight of the hydrophilic polymer brushes on the obtained MIP microspheres cannot be directly measured.

Method used

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  • Preparation method for molecularly imprinted polymer microballoon with hydrophilic high-molecular brush
  • Preparation method for molecularly imprinted polymer microballoon with hydrophilic high-molecular brush
  • Preparation method for molecularly imprinted polymer microballoon with hydrophilic high-molecular brush

Examples

Experimental program
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Effect test

example 1

[0028] Add 150mg of MIP microspheres with 2,4-D as template (double bond content of 0.0408mmol / g) into an eggplant-shaped bottle containing 30mL of dimethylformamide, and then add 0.0736mmol of polyethylene glycol macromolecule Chain transfer agent (M n =5000) and 0.0238mmol of azobisisobutyronitrile (AIBN). After freezing and pumping five times to remove oxygen, the reaction system was sealed, placed in a 60°C constant temperature oil bath, reacted for 48 hours, and centrifuged at high speed to obtain the reaction product.

[0029] Surface grafted hydrophilic polyethylene glycol macromolecular brush (M n =5000) of the non-imprinted polymer microspheres.

example 2

[0031] 150mg of MIP microspheres with 2,4-D as template (double bond content of 0.0408mmol / g) were added to an eggplant-shaped bottle containing 30mL of dimethylformamide, and then 0.0736mmol of poly(N-isopropyl) Acrylamide) macromolecular chain transfer agent (M n,NMR = 10300) and 0.0238 mmol of azobisisobutyronitrile (AIBN). After freezing and pumping five times to remove oxygen, the reaction system was sealed, placed in a 60°C constant temperature oil bath, reacted for 48 hours, and centrifuged at high speed to obtain the reaction product.

[0032] Surface grafted hydrophilic poly(N-isopropylacrylamide) macromolecular brush (M n,NMR =10300) The process of non-imprinted polymer microspheres is the same as above.

example 3

[0034] Add 50mg of MIP microspheres (double bond content 0.0383mmol / g) with propranolol as template into an eggplant-shaped bottle containing 10mL dimethylformamide, and then add 0.0245mmol polyethylene glycol macromolecular chain transfer agent (M n =5000) and 0.0159mmol of azobisisobutyronitrile (AIBN). After freezing and pumping five times to remove oxygen, the reaction system was sealed, placed in a 60°C constant temperature oil bath, reacted for 48 hours, and centrifuged at high speed to obtain the reaction product.

[0035] Surface grafted hydrophilic polyethylene glycol macromolecular brush (M n =5000) The process of non-imprinted polymer microspheres is the same as above.

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Abstract

The invention relates to a preparation method for a molecularly imprinted polymer microballoon with a hydrophilic high-molecular brush. The molecularly imprinted polymer microballoon with the hydrophilic high-molecular brush is prepared by performing chemical coupling reaction on a molecularly imprinted polymer microballoon with the surface containing a C=C bond and a hydrophilic macro-molecule chain transferring agent in the presence of a common radial initiator. The molecularly imprinted polymer microballoon has the advantages of simple synthetic method, wide application scope, definite product structure and the like. The obtained molecularly imprinted polymer microballoon with the surface containing the hydrophilic high-molecular brush has wide application prospect in a plurality of fields such as medical clinic immunoassay, food safety, environment monitoring, biological technology and the like.

Description

Technical field [0001] The present invention relates to a new method for preparing molecularly imprinted polymer microspheres with hydrophilic polymer brushes on the surface, and specifically relates to a new surface grafting method by which the hydrophilic surface can be obtained Molecularly imprinted polymer microspheres of polymer brushes. Background technique [0002] Molecular imprinting technology is a simple and efficient new method for preparing polymer receptors with specific recognition sites. The polymers obtained from it are called molecularly imprinted polymers (MIPs). MIPs not only have excellent mechanical resistance, chemical resistance and heat resistance, easy preparation and low cost, but also have high affinity and selectivity comparable to natural bioreceptors, so they are used in solid phase extraction. Many fields such as chromatographic separation, immunoassay, sensors, enzyme-like catalysis, organic synthesis, drug delivery and biopharmaceuticals have sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12B01J20/26B01J20/28B01J20/30
Inventor 张会旗赵曼陈晓靖
Owner NANKAI UNIV
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