Less immunogenic binding molecules

A technology that combines molecules and molecules, applied in the direction of immunoglobulins, hybrid immunoglobulins, and anti-animal/human immunoglobulins, and can solve problems such as reducing specific activity
CN1950399AInactive Publication Date: 2007-04-18MICROMET AG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MICROMET AG
Publication Date
2007-04-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least two domains specifically binds to / interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain, wherein said amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one further antigen-interaction-site and / or at least one further effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Moreover, the invention concerns a method for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.
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Description

technical field

[0001] The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains, wherein one of said at least two domains specifically binds / interacts with a human CD3 complex and said domain comprising a light chain amino acid sequence from an antibody, wherein said amino acid sequence is a specifically identified amino acid sequence containing specific amino acid substitutions, and the other domain is or contains at least one other antigen interaction site and / or at least one other effector domain. The present invention also provides nucleic acid molecules encoding the bispecific binding molecules of the present invention, vectors containing said nucleic acid molecules and host cells transformed with said vectors. In addition, the invention relates to methods of producing bispecific binding molecules of the invention and compositions comprising bispecific binding molecules of the invention, nucleic aci...

Claims

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