Preparation and application of tetraethylenepentamine carbon quantum dot/monomer co-bonded silica gel hydrophilic chromatography stationary phase

A tetraethylenepentamine carbon quantum and tetraethylenepentamine technology is applied in the field of separation of base nucleosides, amino acids and ginsenosides, achieving excellent separation effects, simple and reliable methods, and cheap and easy-to-obtain raw materials
CN110394167AActive Publication Date: 2019-11-01LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2019-11-01

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Abstract

The invention discloses a preparation method of a tetraethylenepentamine carbon quantum dot / monomer co-bonded silica gel chromatographic packing. The preparation method comprises the following steps:reacting tetraethylenepentamine (TEPA) serving as a precursor substance and a medium with citric acid to prepare a mixture of functionalized carbon quantum dots (TEPACDs) and a TEPA monomer; and carrying out silanization treatment on the functionalized carbon quantum dots TEPACDs, and bonding the silanized functionalized carbon quantum dots TEPACDs to the surface of silica gel to prepare the silica gel chromatographic stationary phase Sil-TEPA / CDs formed by co-bonding of the TEPACDs and the TEPA monomer. Material characterization experiments show that the bonding amount of surface functional groups of the Sil-TEPA / CDs is large, and rich interaction sites can be provided for chromatographic separation of samples. Chromatographic separation experiments show that the hydrophilic chromatographic stationary phase Sil-TEPA / CDs prepared by the invention has good hydrophilic chromatographic selectivity, and has an excellent separation effect on basic nucleoside, amino acids and ginsenoside.
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Description

technical field

[0001] The invention relates to the preparation of a tetraethylenepentamine carbon quantum dot doped tetraethylenepentamine monomer co-bonded silica gel hydrophilic chromatographic filler, which is mainly used for the separation of basic nucleosides, amino acids and ginsenosides, and belongs to the chromatographic stationary phase technology field. Background technique

[0002] Hydrophilic interaction liquid chromatography (HILIC) is an important branch of liquid chromatography, which is suitable for the separation of strongly polar and hydrophilic substances. The development of new hydrophilic chromatographic stationary phases is an important part of the research and application of hydrophilic interaction chromatography.

[0003] Carbon quantum dots have the advantages of various types, easy functionalization, rich surface groups, etc., and have extremely small particle size and moderate adsorption capacity. When used as a silica gel packing bonded phase, i...

Claims

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