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Magnetic compound bone cement and preparation method for same

A bone cement and magnetic technology, which is applied in the preparation of magnetic bone cement and magnetic bone cement, and the preparation of magnetic composite bone cement, can solve the problems of poor degradation performance and non-degradation of bone cement matrix, and reduce the exothermic temperature and collapse properties, good magnetic and heat generation properties, and the effect of reducing the degradation rate

Inactive Publication Date: 2016-11-09
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of this bone cement matrix does not degrade, or the degradation performance is very poor

Method used

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  • Magnetic compound bone cement and preparation method for same
  • Magnetic compound bone cement and preparation method for same
  • Magnetic compound bone cement and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of DMSA-wrapped zinc-doped superparamagnetic ferric oxide nanoparticles

[0036] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230° C. for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles rep...

Embodiment 2

[0049] 1. Preparation of DMSA-wrapped zinc-doped superparamagnetic ferric oxide nanoparticles

[0050] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230° C. for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles rep...

Embodiment 3

[0063] 1. Preparation of DMSA-wrapped zinc-doped superparamagnetic ferric oxide nanoparticles

[0064] FeSO 4 ·(NH 4 ) 2 SO 4 ·6H 2 O and ZnSO 4 Dissolve in 20ml of water so that the precursor reaches 1.73×10 -3 mol Fe 2+ and 2.67×10 -4 mol Zn 2+ the goal of. Next, mix 10ml of oleic acid, 10ml of water and 1g of NaOH, and magnetically stir at room temperature until a uniform solution is obtained. Furthermore, the precursor Fe 2+ and Zn 2+ Pour into this homogeneous solution, and after stirring for a few minutes, the mixed solution turns dark brown. Finally, the solution was transferred into a 50ml reaction kettle, sealed, and heated at 230° C. for 15 hours. After the reaction, cool to room temperature. The product is deposited at the bottom of the kettle, and the nanoparticles are taken out by dissolving with cyclohexane. Then add ethanol into the cyclohexane containing the nanoparticles to precipitate the nanoparticles, and finally wash the nanoparticles rep...

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Abstract

The invention relates to magnetic compound bone cementand a preparation method for the same, and provides a preparation technology for preparing magnetic compound bone cement by mixing calcium phosphate bone cement serving as a substrate and zinc-doped Fe3O4 nanoparticles. The preparation method comprises the following steps: preparing DMSA (dimercaptosuccinic acid)-wrapped zinc-doped superparamagnetic Fe3O4 nanoparticles; preparing beta-TCP (beta-tricalcium phosphate); preparing bone cement solidification liquid; preparing the magnetic compound bone cement. According to the magnetic compound bone cement and the preparation method for the same, the addition of the zinc-doped Fe3O4 nanoparticles can be regulated to regulate the performance of the magnetic bone cement material, for example, the solidification time of the bone cement is prolonged, the solidification heat release temperature and the collapsibility of the bone cement are reduced, the injectability is enhanced, the compressive strength is strengthened, and the excessive degradation speed of brushite is reduced, so that the magnetic compound bone cement is favorable for repair and treatment of bones. The preparation method for the magnetic bone cement material is simple in process and high in operability, and has high popularization value, and clinical using requirements can be met better.

Description

technical field [0001] The present invention relates to a magnetic bone cement and a preparation method of the magnetic bone cement, in particular to a calcium phosphate bone cement as a matrix, and at the same time doped with zinc Fe 3 o 4 Preparation technology of magnetic composite bone cement prepared by mixing nanoparticles. The invention belongs to the technical field of biomedical inorganic materials. Background technique [0002] Bone is the third most common metastatic site of malignant tumors, second only to liver and lung (J Bone Joint Surg, 1997, 79(6):917-932). It was found that about 70% of patients with breast cancer and prostate cancer, about 30% to 40% of patients with thyroid cancer, kidney cancer and bronchial cancer, and 10% of patients with gastrointestinal tumors had tumor bone metastasis (Clinical Cancer Research, 2006, 12 (20 Pt2) : 6243s-6249s). Bone-related events such as severe bone pain, pathological fractures, vertebral body compression, defo...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/54A61L27/58A61K41/00
CPCA61L27/12A61K41/0052A61L27/025A61L27/54A61L27/58A61L2300/102A61L2300/412A61L2400/06
Inventor 何丹农祝闪闪王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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