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Dimercaptosuccinic acid pharmaceutical composition and medical application thereof

A technology of dimercaptosuccinic acid and its composition, which is applied in the field of biomedicine, can solve the problems that have not yet been reported related to dimercaptosuccinic acid immune thrombocytopenic purpura, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-11-09
陈露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between dimercaptosuccinic acid and its pharmaceutical composition and immune thrombocytopenic purpura

Method used

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  • Dimercaptosuccinic acid pharmaceutical composition and medical application thereof
  • Dimercaptosuccinic acid pharmaceutical composition and medical application thereof
  • Dimercaptosuccinic acid pharmaceutical composition and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Grind Hypericum perforatum (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract in the medium, first elute with 25% ethanol for 8 column volumes, then use 70% ethanol for 12 column volumes, collect 70% eluate, and depressurize Concentrate to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 85:1 (10 column volumes), 45:1 ( 8 column volumes), 25:1 (10 column volumes) and 15:...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] This embodiment uses to obtain BALB / C mouse platelet antibody, inoculate on guinea pig body, obtain guinea pig anti-mouse platelet antibody (APS), APS is injected intraperitoneally into BALB / C mouse to establish immune thrombocytopenic purpura animal model, observes The anti-immune thrombocytopenic purpura effect of drugs can increase platelet count, decrease spleen coefficient, and increase bone marrow mature megakaryocytes.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] BALB / C mice, weighing 18-23 g, male and female, SPF grade, were purchased from Guangdong Medical Animal Experiment Center; guinea pigs, female, weighing 350 g, normal grade, were purchased from Guangdong Medical Animal Experiment Center.

[0028] 1.2 Reagents and samples

[0029] Dimercaptosuccinic acid was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the prepar...

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Abstract

The invention discloses a dimercaptosuccinic acid pharmaceutical composition and medical application thereof. The dimercaptosuccinic acid pharmaceutical composition comprises dimercaptosuccinic acid and a novel-structure natural product compound (I); in single action of the dimercaptosuccinic acid and the compound (I), a treatment effect on immune thrombocytopenic purpura is achieved; in joint action of the dimercaptosuccinic acid and the compound (I), the treatment effect on immune thrombocytopenic purpura is improved remarkably. The dimercaptosuccinic acid pharmaceutical composition can be developed into medicines for treating immune thrombocytopenic purpura and has prominent substantial characteristics and remarkable progress as compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of dimercaptosuccinic acid, in particular to a pharmaceutical composition of dimercaptosuccinic acid and its medical application. Background technique [0002] Dimercaptosuccinic acid is an antidote, which is often used clinically to treat lead, mercury, arsenic, and antimony poisoning. It can promote the excretion of copper and is suitable for the treatment of hepatolenticular degeneration. [0003] So far, there is no report on the correlation between dimercaptosuccinic acid and its pharmaceutical composition and immune thrombocytopenic purpura. Contents of the invention [0004] The purpose of the present invention is to provide a pharmaceutical composition of dimercaptosuccinic acid, which contains dimercaptosuccinic acid and a natural product with a novel structure, and dimercaptosuccinic acid and the natural product can be synergistically treated Immune thromboc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00A61K31/585A61P7/04A61P37/02A61K31/194
CPCC07J73/003A61K31/194A61K31/585
Inventor 陈露
Owner 陈露
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