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Drug-deterioration discoloration indicating technology

A drug and indication technology, applied in the direction of color/spectral characteristic measurement, etc., can solve the problem of unavailable drugs and achieve the effect of ensuring drug safety

Inactive Publication Date: 2016-12-07
王鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although methods such as spectroscopy and chromatography can determine the changes in the ingredients of these drugs, only institutions such as universities and scientific research institutes have these instruments, and most ordinary people cannot obtain these data and use them to judge whether the drug has deteriorated.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 .Light controllable discoloration indicator sheet applied to the photodeterioration indication of vitamin B2

[0016] (1) Determination of deterioration-inducing factor parameters: According to light measurement results, under 80,000 Lux sunlight, vitamin B2 partially decomposes and deteriorates within 5 minutes; under 200 Lux darker light, vitamin B2 decomposes for about a week.

[0017] (2) Prepare an indicator sheet according to the amount of metamorphic light: Coat CdTe quantum dots (CdTe-DMSA quantum dots) wrapped in dimercaptosuccinic acid on a plastic sheet, and then an equal volume of 1´10 -5 M Cu 2+ The solution is coated on the same plastic sheet and mixed with the coated CdTe-DMSA quantum dot solution to control the amount of electrons released by the quantum dots under light by exciton annihilation, so that it is just in step (1). Under certain lighting parameters, vat dyes can undergo a color change that can be distinguished by the naked eye. ...

Embodiment 2

[0019] Example 2 . According to steps (1) and (2) in Example 1, a vitamin B2 medicine bottle with an indicator sheet was made to contain newly produced vitamin B2. Put the drug in a light-proof cabinet, keep it in this state for a month, open the bottle, and find that the indicator sheet has not changed color, indicating that the drug has not decomposed and can be used continuously.

Embodiment 3

[0020] Example 3 .The controllable indicator sheet is applied to the deterioration indication of nitroglycerin:

[0021] (1) Infrared Spectroscopy 30 o The amount of light required for the deterioration of nitroglycerin medicines under C conditions.

[0022] (2) Dimercaptosuccinic acid-wrapped ZnO nanoparticles (DMSA-ZnO nanoparticles) were prepared by hydrothermal method, and its concentration was adjusted so that it was mixed with NBT solution and dried at 30 o The amount of light required for color change at C temperature is consistent with the amount of light required for the deterioration of nitroglycerin.

[0023] (3) Drop-coat the adjusted DMSA-ZnO nanoparticles and NBT solution on the BOPP film, cut it into a suitable shape and stick it on the mouth of the medicine bottle containing nitroglycerin.

[0024] (4) Put the medicine in the chest pocket so that the ambient temperature of the medicine is at 30 o Around C, walk in the sun for 30 minutes. It was found that...

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PUM

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Abstract

The invention relates to a drug-deterioration discoloration indicating technology. The drug-deterioration discoloration indicating technology includes: forming light-induced or thermally-induced discoloration material through one or several kinds of II-VI compounds of CdTe, ZnO and the like, dimercaptosuccinic acid as well as mercaptoacetic acid and nitro blue tetrazolium or simple derivatives thereof or combination of the nitro blue tetrazolium with other dyes; affecting quantum character of photoelectron of the material by adding Cu<2+>, ag<+> plasma in the material or regulating material solution concentration and pH (potential of hydrogen) conditions to enable the material to produce discoloration visible to the naked eyes after the material receives light quantity or heat and the like capable of deteriorating drugs; producing the well-regulated material into thin films to be attached to drug packaging or coated on surfaces of the drugs to indicate decomposition of deterioration of the drugs through discoloration. Discoloration of special materials is synchronously induced by the aid of factors of light, heat and the like capable of inducing deterioration of relevant drugs, so that visible synchronous monitoring on deterioration of the drugs is realized, and drug safety of people is guaranteed.

Description

technical field [0001] The invention belongs to the field of visual monitoring of deterioration and failure of medicines. Specifically, factors that can induce deterioration of relevant medicines, such as light and heat, are used to synchronously induce discoloration of special materials, so as to realize the visual synchronous monitoring of deterioration of medicines. Background technique [0002] Some commonly used medicines, such as vitamin B2 and nitroglycerin, will deteriorate and become invalid after being exposed to light for a period of time. Especially in daily life, it is easy to use and store medicines improperly, which causes these "delicate" medicines to expire prematurely due to exposure to light, heat and other factors before the expiration date. However, the failure of these medicines cannot be found by usual methods including visual identification, which can easily lead to accidental ingestion and damage to health. Taking vitamin B2 tablets as an example, i...

Claims

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Application Information

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IPC IPC(8): G01N21/29
Inventor 王鹏
Owner 王鹏
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