Drug-deterioration discoloration indicating technology
A drug and indication technology, applied in the direction of color/spectral characteristic measurement, etc., can solve the problem of unavailable drugs and achieve the effect of ensuring drug safety
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Embodiment 1
[0015] Example 1 .Light controllable discoloration indicator sheet applied to the photodeterioration indication of vitamin B2
[0016] (1) Determination of deterioration-inducing factor parameters: According to light measurement results, under 80,000 Lux sunlight, vitamin B2 partially decomposes and deteriorates within 5 minutes; under 200 Lux darker light, vitamin B2 decomposes for about a week.
[0017] (2) Prepare an indicator sheet according to the amount of metamorphic light: Coat CdTe quantum dots (CdTe-DMSA quantum dots) wrapped in dimercaptosuccinic acid on a plastic sheet, and then an equal volume of 1´10 -5 M Cu 2+ The solution is coated on the same plastic sheet and mixed with the coated CdTe-DMSA quantum dot solution to control the amount of electrons released by the quantum dots under light by exciton annihilation, so that it is just in step (1). Under certain lighting parameters, vat dyes can undergo a color change that can be distinguished by the naked eye. ...
Embodiment 2
[0019] Example 2 . According to steps (1) and (2) in Example 1, a vitamin B2 medicine bottle with an indicator sheet was made to contain newly produced vitamin B2. Put the drug in a light-proof cabinet, keep it in this state for a month, open the bottle, and find that the indicator sheet has not changed color, indicating that the drug has not decomposed and can be used continuously.
Embodiment 3
[0020] Example 3 .The controllable indicator sheet is applied to the deterioration indication of nitroglycerin:
[0021] (1) Infrared Spectroscopy 30 o The amount of light required for the deterioration of nitroglycerin medicines under C conditions.
[0022] (2) Dimercaptosuccinic acid-wrapped ZnO nanoparticles (DMSA-ZnO nanoparticles) were prepared by hydrothermal method, and its concentration was adjusted so that it was mixed with NBT solution and dried at 30 o The amount of light required for color change at C temperature is consistent with the amount of light required for the deterioration of nitroglycerin.
[0023] (3) Drop-coat the adjusted DMSA-ZnO nanoparticles and NBT solution on the BOPP film, cut it into a suitable shape and stick it on the mouth of the medicine bottle containing nitroglycerin.
[0024] (4) Put the medicine in the chest pocket so that the ambient temperature of the medicine is at 30 o Around C, walk in the sun for 30 minutes. It was found that...
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