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50 results about "Thiomalic acid" patented technology
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A thiomalic acid or mercaptosuccinic acid is a dicarboxylic acid containing a thiol functional group. As suggested by its name, it contains an SH group instead of an OH group on malic acid. Salts and esters are known as thiomalates.
Preparation method for quantum dot fluorescent imprinted polymer
InactiveCN103739846AGood optical stabilityAvoid slow recognitionOther chemical processesFluorescence/phosphorescenceThio-Thiomalic acid
The invention provides a preparation method for a quantum dot fluorescent imprinted polymer and belongs to the technical field of preparation of environment-friendly materials. The preparation method comprises the following steps: firstly, synthesizing a precursor sodium hydrogen telluride in a needle pipe; synthesizing a water-soluble CdTe quantum dot by using thiomalic acid as a protection agent; finally, synthesizing the quantum dot fluorescent imprinted polymer which takes cyhalothrin as a template molecule by using a reverse micro-emulsion method so as to optically detect the cyhalothrin. The prepared quantum dot fluorescent imprinted polymer has high optical stability and pH (Potential of Hydrogen) stability and has the capability of selectively identifying the cyhalothrin.
Owner:JIANGSU UNIV
Polyethylene glycol hydrogel for orthotopic injection and preparation method thereof
InactiveCN102898661AGood biocompatibilityPromote degradationPharmaceutical non-active ingredientsPolymer scienceThiomalic acid
The invention discloses a method for preparing polyethylene glycol hydrogel for orthotopic injection. The method comprises the following steps of: preparing a multi-mercapto linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and thiomalic acid as raw materials and rare earth trifluoromethanesulfonate as a catalyst; preparing a double-bond linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and maleic anhydride as starting raw materials and rare earth trifluoromethanesulfonate as a catalyst; and dissolving multi-mercapto linear polyethylene glycol polyether ester and multiple double-bond linear polyethylene glycol polyether esters in a phosphate buffered saline (PBS) buffer solution respectively, quickly mixing the two solutions uniformly and standing the mixed solution to obtain the polyethylene glycol hydrogel for orthotopic injection. The method is simple; conditions are easy to control, so that the method is suitable for industrial production. The invention also discloses the polyethylene glycol hydrogel for orthotopic injection, which is degradable.
Owner:ZHEJIANG UNIV
Preparation method of CdSe/CdS core-shell structured quantum dot photocatalyst and application thereof
ActiveCN103599799ADegradation reachesNo wastePhysical/chemical process catalystsWater/sewage treatment by irradiationThio-Thiomalic acid
The invention relates to a preparation method of a CdSe / CdS core-shell structured quantum dot photocatalyst, comprising the following steps: firstly, preparing CdSe quantum dot, adding selenium powder into a Na2SO3 solution and carrying out magnetic stirring to obtain a Na2SeSO3 solution; then, adding CdCl2 and thiomalic acid into deionized water and mixing, adjusting pH of the solution by the use of NaOH, adding the newly-prepared Na2SeSO3 solution under the protection of nitrogen, heating with oil bath to 100 DEG C, refluxing, and cooling to room temperature; preparing a CdSe / CdS core-shell structured quantum dot photocatalyst, weighing CdCl2, dissolving CdCl2 and adding it into the above prepared solution, and stirring; and finally adding a certain amount of sodium hyposulfite and stirring, refluxing at 100 DEG C for 1-4 hours, cooling to room temperature, centrifuging, and drying to obtain the CdSe / CdS core-shell structured quantum dot photocatalyst, wherein the mole ratio of CdSe to CdS is 1:(1-4).
Owner:JIANGSU UNIV
Process for production of surface-coated inorganic particles
InactiveCN101765562AImprove performanceMaterial nanotechnologyNanomagnetismLong chain fatty acidOrganic solvent
Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible ina polar solvent.
Owner:TOKYO INST OF TECH
Process for preparing sodium antimony sulfide microwires and array thereof
The invention discloses a preparing method of antimony sulphate nanometer-micrometer line and array, which comprises the following steps: weighing potassium antimony tartrate, dihydrate citric acid trisodium, thiomalic acid at 10:11:1-60 molecular proportion; stirring these raw materials in the secondary distilled water sequently; loading the composition in the polytetrafluoroethylene liner of stainless steel high-pressure autoclave to seal; reacting at 140-240 deg.c for 3-24 h to obtain the product. The beam-shaped antimony sulphate nanometer-micrometer line and array can grow on the surface of substrate with ITO glass, tungsten filament or SiN micrometer fiber in the polytetrafluoroethylene liner simultaneously, which possesses excellent single-crystal structure.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Process for production of surface-coated inorganic particles
InactiveUS20100254908A1Material nanotechnologyLiquid surface applicatorsLong chain fatty acidOrganic solvent
Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.
Owner:TOKYO INST OF TECH
Preparation method of dimercaptosuccinic acid modified porous magnetic loofah sponge composite microsphere
InactiveCN107511133AGood physical and chemical stabilityGood mechanical strengthOther chemical processesWater contaminantsIonSorbent
The invention discloses a preparation method of a dimercaptosuccinic acid modified porous magnetic loofah sponge composite microsphere. The method is characterized in that firstly, loofah sponge powder is dissolved in 1-ethyl-3 methylimidazole thiocyanate under the effect of cellulase; nanometer bismuth ferrite is added; a porous magnetic loofah sponge composite microsphere is obtained through preparation; then, the surface of the porous magnetic loofah sponge composite microsphere is subjected to amination to obtain an aminated porous magnetic loofah sponge composite microsphere; finally, the following ingredients in mass percentage concentration: 60 to 68 percent of de-ionized water, 4 to 8 percent of sodium hydroxide and 10 to 15 percent of dimercaptosuccinic acid are added into a reactor; stirring is performed for dissolution; 15 to 20 percent of aminated porous magnetic loofah sponge composite microsphere reacts for 1h at the constant temperature being 70+ / -2 DEG C; solid-liquid separation and drying are performed to obtain the dimercaptosuccinic acid modified porous magnetic loofah sponge composite microsphere. An adsorbent has high adsorption capacity on cobalt and nickel; the cost is low; the green and environment-friendly effects are achieved; the magnetism is realized; the mechanical strength is high; the adsorbent can be repeatedly used for 10 times or higher; the adsorbent can be easily separated.
Owner:UNIV OF JINAN
Preparation method of CdTe quantum dots for fluorescence detection of aspirin
InactiveCN104194791AAccurate detectionShort synthesis timeFluorescence/phosphorescenceLuminescent compositionsDrug contentFluorescence
The invention relates to a preparation method of CdTe quantum dots for the fluorescence detection of aspirin, which belongs to the technical field of material preparation and drug content detection. According to the technical scheme of the invention, the method comprises the steps of mixing cadmium chloride (CdCl2.2.5H2O) and thiomalic acid (MSA) into an aqueous solution with a certain pH; mixing NaBH4 and Te powder and carrying out ultrasonic reaction on the obtained mixture so as to obtain a NaHTe solution; mixing the two solutions; and carrying out reflux reaction to generate MSA-modified CdTe quantum dots. CdTeQDs obtained by using the method disclosed by the invention have good optical properties and an capability of rapidly detecting the aspirin content; compared with traditional high performance liquid, ultraviolet, raman detection methods and the like, the method for the fluorescence detection of aspirin by CdTeQDs can achieve the effects of short detection time, high detection sensitivity and accuracy, and wide detection range.
Owner:JIANGSU UNIV
Nanogold modified polymer monolithic column, and preparation method and application thereof
InactiveCN106492506AImprove adsorption capacityRealize online analysisOther chemical processesMaterial analysis by electric/magnetic meansRare-earth elementGlycidyl methacrylate
The invention discloses a method for analyzing a rare earth element in seawater and human whole blood through online combination of ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and capillary microextraction of a mercaptobutanedioic acid modified nanogold modified polymer monolithic column. Glycidyl methacrylate is taken as a monomer, ethylene glycol dimethacrylate is taken as a crosslinking agent, an in situ polymerization method is used to obtain the polymer monolithic column, then the surface of an epoxy group of the polymer monolithic column is subjected to a series of chemical reactions to enable the polymer monolithic column to be rich in sulfydryl, the nanogold is modified through a chemical bonding mode, and finally, the nanogold is taken as an intermediate ligand, and the mercaptobutanedioic acid having an affinity effect on the rare earth element is modified on the surface of the nanogold. The monolithic column is used to separate and enrich the rare earth element in a complex sample, the online analysis of the rare earth element in the seawater and whole human blood is realized, the adsorption capacity (3-6.5 times) of the monolithic column on the rare earth element is remarkably improved, and the method has the advantages of high sensitivity, high sample flux, low sample consumption, wider pH scope of application, higher capability of resisting matrix interference and the like.
Owner:WUHAN UNIV
Drug-deterioration discoloration indicating technology
InactiveCN106198410AGuarantee drug safetyColor/spectral properties measurementsDrug utilisationAcetic acid
The invention relates to a drug-deterioration discoloration indicating technology. The drug-deterioration discoloration indicating technology includes: forming light-induced or thermally-induced discoloration material through one or several kinds of II-VI compounds of CdTe, ZnO and the like, dimercaptosuccinic acid as well as mercaptoacetic acid and nitro blue tetrazolium or simple derivatives thereof or combination of the nitro blue tetrazolium with other dyes; affecting quantum character of photoelectron of the material by adding Cu<2+>, ag<+> plasma in the material or regulating material solution concentration and pH (potential of hydrogen) conditions to enable the material to produce discoloration visible to the naked eyes after the material receives light quantity or heat and the like capable of deteriorating drugs; producing the well-regulated material into thin films to be attached to drug packaging or coated on surfaces of the drugs to indicate decomposition of deterioration of the drugs through discoloration. Discoloration of special materials is synchronously induced by the aid of factors of light, heat and the like capable of inducing deterioration of relevant drugs, so that visible synchronous monitoring on deterioration of the drugs is realized, and drug safety of people is guaranteed.
Owner:王鹏
Preparation method of co-reactant-free electrochemical luminescence immunosensor
ActiveCN112858416AHigh ECL EfficiencyImprove performanceChemiluminescene/bioluminescenceMaterial electrochemical variablesZinc bromideThio-
The invention belongs to the field of analytical technical methods, and relates to a preparation method of a co-reactant-free electrochemical luminescence immunosensor, wherein the preparation method mainly comprises the steps: (1) preparing an oil-soluble indium phosphide nanocrystalline dispersion solution by using indium bromide, tris(dimethylamino) phosphine, zinc bromide and oleylamine as raw materials; (2) preparing oil-soluble indium phosphide / zinc sulfide nanocrystals by taking the oil-soluble indium phosphide nanocrystals, zinc acetate and n-dodecanethiol as raw materials; (3) dissolving the oil-soluble indium phosphide / zinc sulfide nanocrystals in dichloromethane, and adding N,N-dimethylformamide, thiohydracrylic acid and thiomalic acid to prepare a water-soluble indium phosphide / zinc sulfide nanocrystal solution; (4) preparing a water-soluble indium phosphide / zinc sulfide nanocrystal labeled secondary antibody; and (5) preparing the co-reactant-free electrochemical luminescence immunosensor. In the preparation process, no co-reaction agent needs to be added, so that the damage to biological substances and cells caused by the co-reaction agent is avoided.
Owner:SHANDONG UNIV
A kind of epoxidized polyester resin and its preparation method and application
ActiveCN108503814BLow acid valueImprove stabilityPowdery paintsPolyester coatingsDiethyl terephthalatePolymer science
Owner:黄山市向荣新材料有限公司
Vegetable oil-based waterborne non-isocyanate polyurethane acrylate
ActiveCN111393636AWide variety of sourcesSolve problems such as poor water resistancePolyurea/polyurethane coatingsPolymer scienceGlycidyl methacrylate
The invention belongs to the field of polymer materials, and relates to vegetable oil-based waterborne non-isocyanate polyurethane acrylate and a coating thereof. According to the method, glycerol cyclic carbonate (A), 2-mercaptosuccinic acid (B), polyhydroxylated vegetable oil, diamine (C) and glycidyl methacrylate (D) are used as the raw materials, and multi-step reaction is carried out to prepare the novel vegetable oil-based waterborne polyurethane acrylate, which is then prepared into paint. The novel vegetable oil-based waterborne polyurethane acrylate not only effectively solves the problems of poor water resistance and the like of toxic isocyanate or waterborne polyurethane acrylate paint used in the existing waterborne polyurethane acrylate synthesis process, but also has excellent physical properties. Predictably, the material can have a wide market prospect, and is especially suitable for the fields of furniture wood lacquer, kitchen and bath coatings and the like.
Owner:广东恒和永盛集团有限公司
Medicine box for preparing 99mTc complex and preparation method and use thereof
InactiveCN101337081AImprove performanceHigh myocardial absorptionRadioactive preparation carriersVitamin CButanedioic acid
The invention relates to a medicine box used for preparing <99m>Tc complex, and a method for preparing novel <99m>Tc mixed ligand complex containing carbon monoxide (CO), 2, 3-dimercaptosuccinic acid (DMSA) and tetra (2-methoxy isobutyronitrile) cuprous (I) tetrafluoroborate complex salt (MIBI) by utilizing the medicine box. The medicine box comprises the following three medicine boxes: firstly, medicine box A which is composed of sodium carbonate, vitamin C, sodium borohydride, seignette salt, lactose and CO gas, and the weight ratio is (5-100):(5-100):(10-200):(15-300):(20-400):(10-200); secondly, medicine box B which is composed of DMSA and the vitamin C, and the weight ratio is (5-100):(5-100); and thirdly, medicine box C which is composed of tartaric acid, MIBI, and the vitamin C, and the weight ratio is (5-100):(1-20):(5-100). The preliminary biological experiments show that the mixed ligand complex <99mTc(CO)3(DMSA)(MIBI)> prepared by utilizing the medicine box has good myocardial uptake and detention, the uptake in the liver is greatly reduced, the fault that the liver uptake of the prior myocardial imaging agent <99m>Tc-MIBI is high can be overcome, and a higher heart / liver ratio can be achieved in 30 minutes after the administration, and thereby the medicine box is favorable for the myocardial imaging in the early stage.
Owner:BEIJING NORMAL UNIVERSITY
Silver nanowires, and production method and dispersion of the same
InactiveUS20170120327A1Good dispersionRaise the sintering temperatureTransportation and packagingMetal-working apparatusMONOETHANOLAMINE THIOGLYCOLATEThiomalic acid
Silver nanowires coated with, instead of a polymer protective agent such as PVP, an organic protective agent having a smaller molecular weight are provided. The silver nanowires have an average diameter of 100 nm or less and an average length of 5 μm or more, and a thiol having a molecular weight of 75 to 300 is adhered on surfaces of the metal silver. The silver nanowires have a thiol containing one thiol group in the structure adhered thereon. A thiol having only one thiol group (—S—H) in a molecule is a suitable target. Examples thereof include 1-dodecanethiol, 1-decanethiol, 1-octanethiol, 3-mercapto-1,2-propanediol, monoethanolamine thioglycolate, ammonium thioglycolate, and thiomalic acid.
Owner:UNIVERSITY OF SHIGA PREFECTURE +1
Process for production of surface-coated inorganic particles
Owner:TOKYO INST OF TECH
Method for detecting salbutamol based on SPR technology
PendingCN112526120ASolve the problem of steric hindranceHigh sensitivityTransmissivity measurementsBiological testingButanedioic acidSalbutamol
The invention discloses a method for detecting salbutamol based on an SPR technology. According to the method, mercaptan SAMs with different mercapto groups and carboxyl groups are introduced to adjust the concentration of carboxyl functional groups on a surface; traditional connecting molecules arereplaced with double-mercapto group and double-carboxyl group DMSA; and an SPR signal is enhanced byusing MoS2 and AuNPs, and therefore, the detection sensitivity of an SPR biosensor can be enhanced.
Owner:INST OF QUALITY STANDARDS & TESTING TECH FOR AGRO PROD OF SHANDONG ACADEMY OF AGRI SCI
Application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection
InactiveCN107789358AEnhanced inhibitory effectSalicyclic acid active ingredientsTetracycline active ingredientsSuccinic acidEnterovirus d68 infection
The invention provides application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection, particularly relates to application of meclocycline sulfosalicylate,tannic acid, meso-2,3-diisopropyl-succinic acid, disulfiram, cefaclor monohydrate and aloe-emodin in resisting enterovirus-D68 infection. The compounds can be used for suppressing activity of NS3C protease of enterovirus-D68, and would be used for preparation of small-molecule inhibitors to enterovirus-D68.
Owner:TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
2-(diphenylthiophosphoryl) succinate as well as synthesis method and application thereof
ActiveCN114315896AHigh flame retardant efficiencyFast charcoal speedGroup 5/15 element organic compoundsButanedioic acidThio-
The invention relates to 2-(diphenylthiophosphoryl) succinate as well as a synthesis method and application thereof. The synthesis method comprises the following steps: by taking triethylamine as an acid-binding agent under the protection of nitrogen atmosphere, carrying out reaction on diphenylphosphonium chloride and 2-mercaptosuccinic acid diester to prepare a 2-((diphenylphosphono) thio) succinic acid diester intermediate; and then the 2-(diphenylthiophosphoryl) succinate is prepared through a rearrangement reaction catalyzed by iodine. The 2-(diphenylthiophosphoryl) succinic acid (ester) (DPS-MA) phosphorus-containing flame retardant provided by the invention has a higher char forming speed and better flame retardant efficiency than a 2-(diphenylphosphoryl) succinic acid (ester) (DPO-MA) phosphorus-containing flame retardant.
Owner:HUBEI UNIV
A kind of chalcopyrite flotation compound inhibitor and chalcopyrite flotation method
The invention provides a chalcopyrite flotation composite depressant, which includes Cu-containing 2+ compounds and thiomalic acid. The present invention also provides a kind of chalcopyrite flotation method, in this method, add compound inhibitor in the chalcopyrite slurry, copper sulfate consumption 200-500mg / L in the composite inhibitor, thiomalic acid consumption 200-500mg / L, The mass ratio of copper sulfate and thiomalic acid is 1:1. The inhibitor of the present invention is a composite inhibitor of thiomalic acid strengthened by copper ions. This new type of composite inhibitor is the first in the field of flotation of copper-containing ores. It is used as an inhibitor in combination with ions and sulfhydryl compounds in the future. A new way of thinking is provided.
Owner:XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
Method for preparing fibrous zirconium dioxide aerogel
PendingCN114873640AImprove temperature resistanceLarge specific surface areaNanotechnologyAerogel preparationSupercritical dryingButanedioic acid
The invention discloses a method for preparing fibrous zirconium dioxide aerogel, and particularly relates to a method for preparing nano fibrous zirconium dioxide aerogel by taking hydrogen peroxide as a nucleation inducer and taking mercaptosuccinic acid as a gel accelerator, which comprises the following specific steps: 1) taking inorganic metal zirconium salt as a zirconium source, and dissolving the zirconium source in absolute ethyl alcohol; 2) taking hydrogen peroxide as a nucleation inducer, adding the hydrogen peroxide into the dissolved zircon salt, adding a gel accelerator mercaptosuccinic acid, quickly stirring, sealing, and putting into a drying oven to obtain wet gel; (3) aging the wet gel; and (4) carrying out supercritical drying treatment on the aged wet gel by taking absolute ethyl alcohol and carbon dioxide as supercritical fluid media to finally obtain the nanofiber-shaped zirconium dioxide aerogel. The nano fibrous zirconium dioxide aerogel with low density, high specific surface area and high porosity can be successfully prepared by adjusting the concentration of the inorganic metal zirconium salt and the addition amount of the hydrogen peroxide and the mercaptosuccinic acid.
Owner:CHUZHOU UNIV
Preparation method of injectable polyethylene glycol active hydrogel
InactiveCN111234263AHigh yieldMeet the needs of injection operationsPharmaceutical delivery mechanismProsthesisPolymer sciencePolyethylene glycol
The invention provides a preparation method of injectable polyethylene glycol active hydrogel. Dihydroxy of oligomeric ethylene glycol, maleic anhydride and thiomalic acid are subjected to condensation polymerization under the mild condition of scandium trifluoromethanesulfonate catalysis, a synthesized hydrogel precursor contains multiple sulfydryl groups and double bonds, then through a sulfydryl-alkene click reaction, the double bonds and sulfydryl groups in the hydrogel precursor can completely and efficiently complete the reaction, and the injectable hydrogel is formed. According to the method, the yield of the water-soluble PEG derivative is high, and residues of respective precursors are avoided. Observation, analysis and display of the gelation time show that the gelation time canbe changed through fine adjustment of the pH value so as to meet the actual operation requirements of clinical in-situ forming in the future.
Owner:ZHEJIANG UNIV
A kind of nano-gold modified polymer monolithic column and its preparation method and application
InactiveCN106492506BImprove adsorption capacityRealize online analysisOther chemical processesSolid sorbent liquid separationRare-earth elementChemical reaction
Owner:WUHAN UNIV
<99m>tc marked dimercapto succinate metronidazole esters complex and preparation method and use
InactiveCN101418020BRadioactive preparation carriersGroup 7/17 element organic compoundsImaging agentOxygen
The present invention discloses a <99m> Tc labeled metronidazolyl dimercaptosuccinate complex (DMSAme) and a preparation method thereof. The complex takes [<99m>Tc]<3+> as a centronucleus and has an irregular square pyramid-shaped geometric configuration, wherein an oxygen atom of a Tc=O bond is at a top vertex, and four sulphur atoms of two DMSAme ligand molecules are at four vertexes of a bottom surface. The complex has high radiochemical purity, good stability, good uptake value and retention in tumors and high tumor to muscle ratio, can be widely used in imaging of tumors in human and animal organs, and is a novel tumor hypoxia imaging agent with high promotion and use value.
Owner:BEIJING NORMAL UNIVERSITY +1
A kind of preparation method of electrochemiluminescence immunosensor without co-reaction dosage form
ActiveCN112858416BHigh ECL EfficiencyImprove performanceChemiluminescene/bioluminescenceMaterial electrochemical variablesZinc bromideThio-
The invention belongs to the field of analytical technology methods, and relates to a preparation method of a non-co-reaction formulation type electrochemiluminescence immunosensor, which mainly comprises (1) using indium bromide, tris(dimethylamino)phosphine, zinc bromide and oleylamine as raw materials, prepare oil-soluble indium phosphide nanocrystal dispersion solution; (2) use oil-soluble indium phosphide nanocrystals, zinc acetate and n-dodecanethiol as raw materials to prepare oil-soluble indium phosphide / zinc sulfide nanocrystals; (3) Dissolve oil-soluble indium phosphide / zinc sulfide nanocrystals in dichloromethane, add N,N-dimethylformamide, mercaptopropionic acid and thiomalic acid to prepare a water-soluble indium phosphide / zinc sulfide nanocrystal solution (4) Preparation of water-soluble indium phosphide / zinc sulfide nanocrystal-labeled secondary antibodies; (5) Preparation of non-co-reactive formulation type electrochemiluminescence immunosensors. The present invention does not need to add a co-reactant in the preparation process, thereby avoiding damage to biological substances and cells caused by the co-reactant.
Owner:SHANDONG UNIV
Separation and enrichment of silica gel modified with thiomalic acid - flame atomic absorption spectrometry for the determination of trace lead and cadmium in water samples
InactiveCN103528980BHigh sensitivityHigh selectivityPreparing sample for investigationColor/spectral properties measurementsThio-Physical chemistry
The invention discloses a flame atomic absorption spectrum method for separating, enriching and determining trace lead and cadmium in a water sample by using thiomalamic acid modified silica gel. The flame atomic absorption spectrum method comprises the following steps: taking macro-porous silica gel as a carrier and taking thiomalamic acid as a functional molecule to prepare the thiomalamic acid modified silica gel; taking the thiomalamic acid modified silica gel as an adsorbent to dynamically separate and enrich the lead and the cadmium, and establishing the flame atomic absorption spectrum method. In a concentration range of 0.5-10.0 micrograms / milliliter, a Pb (II) absorbance in an eluting solution and the concentration form a good linear relation: A=0.0122*C-0.0011 (C: micrograms / milliliter); in a concentration range of 0.1-5.0 micrograms / milliliter, a Cb (II) absorbance in the eluting solution and the concentration form a good linear relation: A=0.1898*C+0.001 (C: micrograms / milliliter); the detection limits of the Pb (II) and the Cd(II) are 12.41ng / mL and 0.79ng / mL. According to the flame atomic absorption spectrum method, the sensitivity and the selectivity of the detection are improved and the detection of low-concentration Pb (II) and Cd(II) is easy to be automatic.
Owner:GUILIN UNIVERSITY OF TECHNOLOGY
<99m>tc marked dimercapto succinate metronidazole esters complex and preparation method and use
InactiveCN101418020ARadioactive preparation carriersGroup 7/17 element organic compoundsImaging agentOxygen
The invention discloses a <99m> Tc labeled metronidazolyl dimercaptosuccinate complex (DMSAme) and a preparation method thereof. The complex takes [<99m>Tc]<3+> as a centronucleus and has an irregular square pyramid-shaped geometric configuration, wherein an oxygen atom of a Tc=O bond is at a top vertex, and four sulphur atoms of two DMSAme ligand molecules are at four vertexes of a bottom surface. The complex has high radiochemical purity, good stability, good uptake value and retention in tumors and high tumor to muscle ratio, can be widely used in imaging of tumors in human and animal organs, and is a novel tumor hypoxia imaging agent with high promotion and use value.
Owner:BEIJING NORMAL UNIVERSITY +1
Multifunctional vegetable oil-based acrylate as well as preparation method and application thereof
ActiveCN112920097AGood flexibilityIncrease crosslink densityCoatingsSulfide preparationPolymer scienceGlycidyl methacrylate
The invention relates to a preparation method of multifunctional vegetable oil-based acrylate. The preparation method comprises the following steps: respectively carrying out light click reaction on oleic acid, mercaptoacetic acid and thiomalic acid to prepare oleic acid-based dicarboxylic acid or oleic acid-based tricarboxylic acid with a fatty acid long chain; then respectively reacting with glycidyl methacrylate to prepare polyfunctional oleic acid-based acrylate; and subjecting vegetable oil and thiomalic acid to a light click reaction to prepare vegetable oil-based polycarboxylic acid, and then reacting the vegetable oil-based polycarboxylic acid with glycidyl methacrylate to prepare the multifunctional vegetable oil-based acrylate. The crosslinking density of a cured film is enhanced by improving the functionality of the prepolymer, and the crosslinking density of the cured film is adjusted by adjusting the content of the oleic acid-based polybasic acrylic acid, so that the tensile strength, pencil hardness and chemical corrosion resistance of the cured film are enhanced, the flexibility of the light-cured film is improved, and by introducing the bio-based raw materials such as oleic acid and vegetable oil which are rich in source, the use of petrochemical resources in a photocureable coating is reduced.
Owner:SOUTH CHINA AGRI UNIV +1
Adriamycin nano-particles and preparation method thereof
ActiveCN102552934BAvoid sudden releaseInhibition releaseOrganic active ingredientsPharmaceutical non-active ingredientsButanedioic acidCarboxyl radical
The invention provides adriamycin nano-particles. The adriamycin nano-particles are prepared by compounding adriamycin and a block copolymer with a structure shown as a formula (I) or a formula (II) through electrostatic interaction. A preparation method for the adriamycin nano-particles comprises the following step of: electrostatically compounding the adriamycin and the block copolymer with thestructure shown as the formula (I) or the formula (II) in an aqueous medium to obtain the adriamycin nano-particles. In the aqueous medium, a poly(gamma-propargyl-L-glutamate-g-mercaptosuccinic acid)segment and a polyethylene glycol segment which are contained in the block copolymer wrap the adriamycin into cores of the nano-particles, so the adriamycin composite particles are high in stability.The nano-particles are expected to be gathered at tumor sites in blood circulation through an 'enhanced permeability and retention effect' so as to improve the targeting effect of the adriamycin on the tumor sites. Meanwhile, the electrostatic interaction between a carboxyl group of the block copolymer and an amino group of the adriamycin is easy to eliminate under the condition of low intracellular pH values, so that the intracellular release can be accelerated, and the medicinal effect can be improved.
Owner:CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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