48 results about "Thiomalic acid" patented technology

The invention discloses a method for preparing polyethylene glycol hydrogel for orthotopic injection. The method comprises the following steps of: preparing a multi-mercapto linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and thiomalic acid as raw materials and rare earth trifluoromethanesulfonate as a catalyst; preparing a double-bond linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and maleic anhydride as starting raw materials and rare earth trifluoromethanesulfonate as a catalyst; and dissolving multi-mercapto linear polyethylene glycol polyether ester and multiple double-bond linear polyethylene glycol polyether esters in a phosphate buffered saline (PBS) buffer solution respectively, quickly mixing the two solutions uniformly and standing the mixed solution to obtain the polyethylene glycol hydrogel for orthotopic injection. The method is simple; conditions are easy to control, so that the method is suitable for industrial production. The invention also discloses the polyethylene glycol hydrogel for orthotopic injection, which is degradable.

The invention discloses a preparing method of antimony sulphate nanometer-micrometer line and array, which comprises the following steps: weighing potassium antimony tartrate, dihydrate citric acid trisodium, thiomalic acid at 10:11:1-60 molecular proportion; stirring these raw materials in the secondary distilled water sequently; loading the composition in the polytetrafluoroethylene liner of stainless steel high-pressure autoclave to seal; reacting at 140-240 deg.c for 3-24 h to obtain the product. The beam-shaped antimony sulphate nanometer-micrometer line and array can grow on the surface of substrate with ITO glass, tungsten filament or SiN micrometer fiber in the polytetrafluoroethylene liner simultaneously, which possesses excellent single-crystal structure.

The invention discloses a method for analyzing a rare earth element in seawater and human whole blood through online combination of ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and capillary microextraction of a mercaptobutanedioic acid modified nanogold modified polymer monolithic column. Glycidyl methacrylate is taken as a monomer, ethylene glycol dimethacrylate is taken as a crosslinking agent, an in situ polymerization method is used to obtain the polymer monolithic column, then the surface of an epoxy group of the polymer monolithic column is subjected to a series of chemical reactions to enable the polymer monolithic column to be rich in sulfydryl, the nanogold is modified through a chemical bonding mode, and finally, the nanogold is taken as an intermediate ligand, and the mercaptobutanedioic acid having an affinity effect on the rare earth element is modified on the surface of the nanogold. The monolithic column is used to separate and enrich the rare earth element in a complex sample, the online analysis of the rare earth element in the seawater and whole human blood is realized, the adsorption capacity (3-6.5 times) of the monolithic column on the rare earth element is remarkably improved, and the method has the advantages of high sensitivity, high sample flux, low sample consumption, wider pH scope of application, higher capability of resisting matrix interference and the like.

The invention belongs to the technical field of powder coatings, particularly relates to an epoxidation polyester resin and further discloses a preparation method of the epoxidation polyester resin and application of the prepared powder material. The epoxidation polyester resin is prepared by copolymerizing the raw materials of diethyl terephthalate, glutamic acid, mercaptosuccinic acid, 12-hydroxy stearic acid, dyhydroxyl-1-ethyl benzene, 2,5-dimethyl-2,5-hexanediol, neopentyl glycol, resorcinol diglycidyl ether and the like, the acid value of the finally obtained polyester resin is lower than 2 mgKOH / g, the epoxide equivalent is 800-900 g / mol, the softening point is 85-105 DEG C, the polyester resin can substitute E-12 epoxy resin and the commercially available high-acid-value carboxyl polyester (the acid value is 48-52 mgKOH / g) to cure, a coating film completely reaches the requirement of the powder coating, and the prepared powder coating is better in stability and boiling resistance.

The invention relates to a medicine box used for preparing <99m>Tc complex, and a method for preparing novel <99m>Tc mixed ligand complex containing carbon monoxide (CO), 2, 3-dimercaptosuccinic acid (DMSA) and tetra (2-methoxy isobutyronitrile) cuprous (I) tetrafluoroborate complex salt (MIBI) by utilizing the medicine box. The medicine box comprises the following three medicine boxes: firstly, medicine box A which is composed of sodium carbonate, vitamin C, sodium borohydride, seignette salt, lactose and CO gas, and the weight ratio is (5-100):(5-100):(10-200):(15-300):(20-400):(10-200); secondly, medicine box B which is composed of DMSA and the vitamin C, and the weight ratio is (5-100):(5-100); and thirdly, medicine box C which is composed of tartaric acid, MIBI, and the vitamin C, and the weight ratio is (5-100):(1-20):(5-100). The preliminary biological experiments show that the mixed ligand complex <99mTc(CO)3(DMSA)(MIBI)> prepared by utilizing the medicine box has good myocardial uptake and detention, the uptake in the liver is greatly reduced, the fault that the liver uptake of the prior myocardial imaging agent <99m>Tc-MIBI is high can be overcome, and a higher heart / liver ratio can be achieved in 30 minutes after the administration, and thereby the medicine box is favorable for the myocardial imaging in the early stage.

Silver nanowires coated with, instead of a polymer protective agent such as PVP, an organic protective agent having a smaller molecular weight are provided. The silver nanowires have an average diameter of 100 nm or less and an average length of 5 μm or more, and a thiol having a molecular weight of 75 to 300 is adhered on surfaces of the metal silver. The silver nanowires have a thiol containing one thiol group in the structure adhered thereon. A thiol having only one thiol group (—S—H) in a molecule is a suitable target. Examples thereof include 1-dodecanethiol, 1-decanethiol, 1-octanethiol, 3-mercapto-1,2-propanediol, monoethanolamine thioglycolate, ammonium thioglycolate, and thiomalic acid.

Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.

The invention provides a chalcopyrite flotation composite depressant, which includes Cu-containing 2+ compounds and thiomalic acid. The present invention also provides a kind of chalcopyrite flotation method, in this method, add compound inhibitor in the chalcopyrite slurry, copper sulfate consumption 200-500mg / L in the composite inhibitor, thiomalic acid consumption 200-500mg / L, The mass ratio of copper sulfate and thiomalic acid is 1:1. The inhibitor of the present invention is a composite inhibitor of thiomalic acid strengthened by copper ions. This new type of composite inhibitor is the first in the field of flotation of copper-containing ores. It is used as an inhibitor in combination with ions and sulfhydryl compounds in the future. A new way of thinking is provided.

The invention provides a preparation method of injectable polyethylene glycol active hydrogel. Dihydroxy of oligomeric ethylene glycol, maleic anhydride and thiomalic acid are subjected to condensation polymerization under the mild condition of scandium trifluoromethanesulfonate catalysis, a synthesized hydrogel precursor contains multiple sulfydryl groups and double bonds, then through a sulfydryl-alkene click reaction, the double bonds and sulfydryl groups in the hydrogel precursor can completely and efficiently complete the reaction, and the injectable hydrogel is formed. According to the method, the yield of the water-soluble PEG derivative is high, and residues of respective precursors are avoided. Observation, analysis and display of the gelation time show that the gelation time canbe changed through fine adjustment of the pH value so as to meet the actual operation requirements of clinical in-situ forming in the future.

The invention discloses a method for analyzing a rare earth element in seawater and human whole blood through online combination of ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and capillary microextraction of a mercaptobutanedioic acid modified nanogold modified polymer monolithic column. Glycidyl methacrylate is taken as a monomer, ethylene glycol dimethacrylate is taken as a crosslinking agent, an in situ polymerization method is used to obtain the polymer monolithic column, then the surface of an epoxy group of the polymer monolithic column is subjected to a series of chemical reactions to enable the polymer monolithic column to be rich in sulfydryl, the nanogold is modified through a chemical bonding mode, and finally, the nanogold is taken as an intermediate ligand, and the mercaptobutanedioic acid having an affinity effect on the rare earth element is modified on the surface of the nanogold. The monolithic column is used to separate and enrich the rare earth element in a complex sample, the online analysis of the rare earth element in the seawater and whole human blood is realized, the adsorption capacity (3-6.5 times) of the monolithic column on the rare earth element is remarkably improved, and the method has the advantages of high sensitivity, high sample flux, low sample consumption, wider pH scope of application, higher capability of resisting matrix interference and the like.

The present invention discloses a <99m> Tc labeled metronidazolyl dimercaptosuccinate complex (DMSAme) and a preparation method thereof. The complex takes [<99m>Tc]<3+> as a centronucleus and has an irregular square pyramid-shaped geometric configuration, wherein an oxygen atom of a Tc=O bond is at a top vertex, and four sulphur atoms of two DMSAme ligand molecules are at four vertexes of a bottom surface. The complex has high radiochemical purity, good stability, good uptake value and retention in tumors and high tumor to muscle ratio, can be widely used in imaging of tumors in human and animal organs, and is a novel tumor hypoxia imaging agent with high promotion and use value.

The invention belongs to the field of analytical technology methods, and relates to a preparation method of a non-co-reaction formulation type electrochemiluminescence immunosensor, which mainly comprises (1) using indium bromide, tris(dimethylamino)phosphine, zinc bromide and oleylamine as raw materials, prepare oil-soluble indium phosphide nanocrystal dispersion solution; (2) use oil-soluble indium phosphide nanocrystals, zinc acetate and n-dodecanethiol as raw materials to prepare oil-soluble indium phosphide / zinc sulfide nanocrystals; (3) Dissolve oil-soluble indium phosphide / zinc sulfide nanocrystals in dichloromethane, add N,N-dimethylformamide, mercaptopropionic acid and thiomalic acid to prepare a water-soluble indium phosphide / zinc sulfide nanocrystal solution (4) Preparation of water-soluble indium phosphide / zinc sulfide nanocrystal-labeled secondary antibodies; (5) Preparation of non-co-reactive formulation type electrochemiluminescence immunosensors. The present invention does not need to add a co-reactant in the preparation process, thereby avoiding damage to biological substances and cells caused by the co-reactant.

The invention discloses a flame atomic absorption spectrum method for separating, enriching and determining trace lead and cadmium in a water sample by using thiomalamic acid modified silica gel. The flame atomic absorption spectrum method comprises the following steps: taking macro-porous silica gel as a carrier and taking thiomalamic acid as a functional molecule to prepare the thiomalamic acid modified silica gel; taking the thiomalamic acid modified silica gel as an adsorbent to dynamically separate and enrich the lead and the cadmium, and establishing the flame atomic absorption spectrum method. In a concentration range of 0.5-10.0 micrograms / milliliter, a Pb (II) absorbance in an eluting solution and the concentration form a good linear relation: A=0.0122*C-0.0011 (C: micrograms / milliliter); in a concentration range of 0.1-5.0 micrograms / milliliter, a Cb (II) absorbance in the eluting solution and the concentration form a good linear relation: A=0.1898*C+0.001 (C: micrograms / milliliter); the detection limits of the Pb (II) and the Cd(II) are 12.41ng / mL and 0.79ng / mL. According to the flame atomic absorption spectrum method, the sensitivity and the selectivity of the detection are improved and the detection of low-concentration Pb (II) and Cd(II) is easy to be automatic.

The invention provides adriamycin nano-particles. The adriamycin nano-particles are prepared by compounding adriamycin and a block copolymer with a structure shown as a formula (I) or a formula (II) through electrostatic interaction. A preparation method for the adriamycin nano-particles comprises the following step of: electrostatically compounding the adriamycin and the block copolymer with thestructure shown as the formula (I) or the formula (II) in an aqueous medium to obtain the adriamycin nano-particles. In the aqueous medium, a poly(gamma-propargyl-L-glutamate-g-mercaptosuccinic acid)segment and a polyethylene glycol segment which are contained in the block copolymer wrap the adriamycin into cores of the nano-particles, so the adriamycin composite particles are high in stability.The nano-particles are expected to be gathered at tumor sites in blood circulation through an 'enhanced permeability and retention effect' so as to improve the targeting effect of the adriamycin on the tumor sites. Meanwhile, the electrostatic interaction between a carboxyl group of the block copolymer and an amino group of the adriamycin is easy to eliminate under the condition of low intracellular pH values, so that the intracellular release can be accelerated, and the medicinal effect can be improved.

The invention relates to a preparation method of multifunctional vegetable oil-based acrylate, which uses oleic acid to react with thioglycolic acid and thiomalic acid respectively to prepare oleic acid-based dicarboxylic acid or oleic acid-based Tribasic carboxylic acid, and then react with glycidyl methacrylate to prepare multifunctional oleic acid-based acrylate; then use vegetable oil and thiomalic acid to prepare vegetable oil-based polycarboxylic acid by light click reaction, and then use this Preparation of multifunctional vegetable oil-based acrylates by reaction with glycidyl methacrylate. The present invention enhances the crosslinking density of the cured film by increasing the functionality of the prepolymer itself, and adjusts the crosslinking density of the cured film by adjusting the content of oleic acid-based polyacrylic acid, thereby enhancing the tensile strength of the cured film and enhancing its pencil Hardness, enhance its chemical corrosion resistance, improve the flexibility of light-cured film, introduce rich bio-based raw materials such as oleic acid and vegetable oil, reduce the use of petrochemical resources in light-cured coatings.

The invention discloses a carboxylated organic-inorganic hybrid monolithic column as well as a preparation method and application thereof, belonging to the technical field of detection. The present invention uses the "mercapto-ene" click reaction to use the cheap functional monomer mercaptosuccinic acid containing mercapto and carboxyl groups and the readily available alkenyl silylating agent γ-methyl methacrylate-trimethoxysilane "one pot" Synthesized carboxylated organic-inorganic hybrid monolithic column, which has good permeability, stability and selectivity to Cr(III), and can be used for the separation and analysis of trivalent chromium and hexavalent chromium in environmental water samples , and the preparation reagents are cheap and easy to obtain, the synthesis process is simple, and the reaction efficiency is high.

The invention discloses a poly (epsilon-caprolactone) supported anti-tumor prodrug and a preparation method thereof. The preparation method comprises the following steps of: performing ring opening polymerization on alpha-site bromo-epsilon-caprolactone to generate poly (alpha-site bromo-epsilon-caprolactone); performing a click chemical reaction of mercapto-alpha-site bromo-ester of thiomalic acid on the alpha-site of the poly (alpha-site bromo-epsilon-caprolactone) to obtain poly (epsilon-caprolactone) containing a pendant carboxyl group; and performing a substitution reaction on the poly (epsilon-caprolactone) containing the pendant carboxyl group and anti-tumor medicinal molecules, neutralizing with a strong alkali and weak acid salt solution of an alkali metal, extracting to remove impurities, and dialyzing the purified solution to obtain the anti-tumor prodrug. The anti-tumor prodrug is high in water solubility, can be completely biodegraded, is high in drug carrying quantity and high in purity, and contains groups capable of being further modified; and the preparation method is economic, efficient and nontoxic, and can realize industrialized production.