50 results about "Thiomalic acid" patented technology

The invention belongs to the technical field of powder coatings, particularly relates to an epoxidation polyester resin and further discloses a preparation method of the epoxidation polyester resin and application of the prepared powder material. The epoxidation polyester resin is prepared by copolymerizing the raw materials of diethyl terephthalate, glutamic acid, mercaptosuccinic acid, 12-hydroxy stearic acid, dyhydroxyl-1-ethyl benzene, 2,5-dimethyl-2,5-hexanediol, neopentyl glycol, resorcinol diglycidyl ether and the like, the acid value of the finally obtained polyester resin is lower than 2 mgKOH / g, the epoxide equivalent is 800-900 g / mol, the softening point is 85-105 DEG C, the polyester resin can substitute E-12 epoxy resin and the commercially available high-acid-value carboxyl polyester (the acid value is 48-52 mgKOH / g) to cure, a coating film completely reaches the requirement of the powder coating, and the prepared powder coating is better in stability and boiling resistance.

Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.

The invention provides a chalcopyrite flotation composite depressant, which includes Cu-containing 2+ compounds and thiomalic acid. The present invention also provides a kind of chalcopyrite flotation method, in this method, add compound inhibitor in the chalcopyrite slurry, copper sulfate consumption 200-500mg / L in the composite inhibitor, thiomalic acid consumption 200-500mg / L, The mass ratio of copper sulfate and thiomalic acid is 1:1. The inhibitor of the present invention is a composite inhibitor of thiomalic acid strengthened by copper ions. This new type of composite inhibitor is the first in the field of flotation of copper-containing ores. It is used as an inhibitor in combination with ions and sulfhydryl compounds in the future. A new way of thinking is provided.

The invention discloses a method for analyzing a rare earth element in seawater and human whole blood through online combination of ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and capillary microextraction of a mercaptobutanedioic acid modified nanogold modified polymer monolithic column. Glycidyl methacrylate is taken as a monomer, ethylene glycol dimethacrylate is taken as a crosslinking agent, an in situ polymerization method is used to obtain the polymer monolithic column, then the surface of an epoxy group of the polymer monolithic column is subjected to a series of chemical reactions to enable the polymer monolithic column to be rich in sulfydryl, the nanogold is modified through a chemical bonding mode, and finally, the nanogold is taken as an intermediate ligand, and the mercaptobutanedioic acid having an affinity effect on the rare earth element is modified on the surface of the nanogold. The monolithic column is used to separate and enrich the rare earth element in a complex sample, the online analysis of the rare earth element in the seawater and whole human blood is realized, the adsorption capacity (3-6.5 times) of the monolithic column on the rare earth element is remarkably improved, and the method has the advantages of high sensitivity, high sample flux, low sample consumption, wider pH scope of application, higher capability of resisting matrix interference and the like.

The present invention discloses a <99m> Tc labeled metronidazolyl dimercaptosuccinate complex (DMSAme) and a preparation method thereof. The complex takes [<99m>Tc]<3+> as a centronucleus and has an irregular square pyramid-shaped geometric configuration, wherein an oxygen atom of a Tc=O bond is at a top vertex, and four sulphur atoms of two DMSAme ligand molecules are at four vertexes of a bottom surface. The complex has high radiochemical purity, good stability, good uptake value and retention in tumors and high tumor to muscle ratio, can be widely used in imaging of tumors in human and animal organs, and is a novel tumor hypoxia imaging agent with high promotion and use value.

The invention belongs to the field of analytical technology methods, and relates to a preparation method of a non-co-reaction formulation type electrochemiluminescence immunosensor, which mainly comprises (1) using indium bromide, tris(dimethylamino)phosphine, zinc bromide and oleylamine as raw materials, prepare oil-soluble indium phosphide nanocrystal dispersion solution; (2) use oil-soluble indium phosphide nanocrystals, zinc acetate and n-dodecanethiol as raw materials to prepare oil-soluble indium phosphide / zinc sulfide nanocrystals; (3) Dissolve oil-soluble indium phosphide / zinc sulfide nanocrystals in dichloromethane, add N,N-dimethylformamide, mercaptopropionic acid and thiomalic acid to prepare a water-soluble indium phosphide / zinc sulfide nanocrystal solution (4) Preparation of water-soluble indium phosphide / zinc sulfide nanocrystal-labeled secondary antibodies; (5) Preparation of non-co-reactive formulation type electrochemiluminescence immunosensors. The present invention does not need to add a co-reactant in the preparation process, thereby avoiding damage to biological substances and cells caused by the co-reactant.

The invention discloses a flame atomic absorption spectrum method for separating, enriching and determining trace lead and cadmium in a water sample by using thiomalamic acid modified silica gel. The flame atomic absorption spectrum method comprises the following steps: taking macro-porous silica gel as a carrier and taking thiomalamic acid as a functional molecule to prepare the thiomalamic acid modified silica gel; taking the thiomalamic acid modified silica gel as an adsorbent to dynamically separate and enrich the lead and the cadmium, and establishing the flame atomic absorption spectrum method. In a concentration range of 0.5-10.0 micrograms / milliliter, a Pb (II) absorbance in an eluting solution and the concentration form a good linear relation: A=0.0122*C-0.0011 (C: micrograms / milliliter); in a concentration range of 0.1-5.0 micrograms / milliliter, a Cb (II) absorbance in the eluting solution and the concentration form a good linear relation: A=0.1898*C+0.001 (C: micrograms / milliliter); the detection limits of the Pb (II) and the Cd(II) are 12.41ng / mL and 0.79ng / mL. According to the flame atomic absorption spectrum method, the sensitivity and the selectivity of the detection are improved and the detection of low-concentration Pb (II) and Cd(II) is easy to be automatic.

The invention provides adriamycin nano-particles. The adriamycin nano-particles are prepared by compounding adriamycin and a block copolymer with a structure shown as a formula (I) or a formula (II) through electrostatic interaction. A preparation method for the adriamycin nano-particles comprises the following step of: electrostatically compounding the adriamycin and the block copolymer with thestructure shown as the formula (I) or the formula (II) in an aqueous medium to obtain the adriamycin nano-particles. In the aqueous medium, a poly(gamma-propargyl-L-glutamate-g-mercaptosuccinic acid)segment and a polyethylene glycol segment which are contained in the block copolymer wrap the adriamycin into cores of the nano-particles, so the adriamycin composite particles are high in stability.The nano-particles are expected to be gathered at tumor sites in blood circulation through an 'enhanced permeability and retention effect' so as to improve the targeting effect of the adriamycin on the tumor sites. Meanwhile, the electrostatic interaction between a carboxyl group of the block copolymer and an amino group of the adriamycin is easy to eliminate under the condition of low intracellular pH values, so that the intracellular release can be accelerated, and the medicinal effect can be improved.

The invention relates to a preparation method of multifunctional vegetable oil-based acrylate, which uses oleic acid to react with thioglycolic acid and thiomalic acid respectively to prepare oleic acid-based dicarboxylic acid or oleic acid-based Tribasic carboxylic acid, and then react with glycidyl methacrylate to prepare multifunctional oleic acid-based acrylate; then use vegetable oil and thiomalic acid to prepare vegetable oil-based polycarboxylic acid by light click reaction, and then use this Preparation of multifunctional vegetable oil-based acrylates by reaction with glycidyl methacrylate. The present invention enhances the crosslinking density of the cured film by increasing the functionality of the prepolymer itself, and adjusts the crosslinking density of the cured film by adjusting the content of oleic acid-based polyacrylic acid, thereby enhancing the tensile strength of the cured film and enhancing its pencil Hardness, enhance its chemical corrosion resistance, improve the flexibility of light-cured film, introduce rich bio-based raw materials such as oleic acid and vegetable oil, reduce the use of petrochemical resources in light-cured coatings.