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Application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection

A technology of sulfosalicylic acid A and enterovirus, which is applied in the field of pharmacy and can solve problems such as unreported application

Inactive Publication Date: 2018-03-13
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far, compounds such as meclocycline sulfosalicylate, tannic acid, meso-2,3-dimercaptosuccinic acid, disulfiram, cefaclor monohydrate, aloe-emodin and other compounds have The application in Dow virus type 68 infection has not been reported

Method used

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  • Application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection
  • Application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection
  • Application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection

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Embodiment Construction

[0018] The technical scheme among the present invention is described in detail below by specific embodiment:

[0019] Method steps such as the expression of enterovirus 68 type NS3C protease that the present invention adopts, purification and compound screening method reference literature method (Tan J, George S, Kusov Y, et al.3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses[J].Journal of Virology, 2013,87(8):4339.), the activity assay of the nonstructural protease of enterovirus 68 adopts Dabcyl- KEALFQGPPQF-Glu(Edans)-NH 2 As a substrate; the instrument for measuring the fluorescence intensity is M1000Pro full-wavelength multi-functional microplate detector, the wavelengths of excitation light and emission light are 340nm and 490nm respectively;

[0020] The protein buffer component is 20mM Tris, pH7.3, 100mM NaCl, 1mM EDTA; use the buffer to prepare EV-D68 NS3C protease...

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Abstract

The invention provides application of compounds represented by meclocycline sulfosalicylate in resisting enterovirus-D68 infection, particularly relates to application of meclocycline sulfosalicylate,tannic acid, meso-2,3-diisopropyl-succinic acid, disulfiram, cefaclor monohydrate and aloe-emodin in resisting enterovirus-D68 infection. The compounds can be used for suppressing activity of NS3C protease of enterovirus-D68, and would be used for preparation of small-molecule inhibitors to enterovirus-D68.

Description

technical field [0001] The present invention relates to the technical field of pharmacy, specifically meclocycline sulfosalicylate, tannic acid, meso-2,3-dimercaptosuccinic acid, disulfiram, cefaclor monohydrate, Application of compounds such as aloe-emodin in anti-enterovirus D68 infection. Background technique [0002] Enterovirus 68 (EV-D68 for short) can infect the respiratory tract and can be found in respiratory secretions, and can be transmitted from person to person through close contact, coughing or sneezing. Most susceptible people are children, and the main organ involved is the lungs. The initial symptoms of the respiratory disease caused by it are similar to those of the common cold, including fever, muscle aches, sneezing, coughing, rash, and abdominal pain. It has also been reported that EV-D68 is related to severe respiratory diseases, which can exacerbate asthma and pneumonia, cause febrile fainting and fatal nervous system infections, and in individual cas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K31/60A61K31/7024A61K31/194A61K31/145A61K31/545A61K31/122A61P31/14
CPCA61K31/122A61K31/145A61K31/194A61K31/545A61K31/60A61K31/65A61K31/7024
Inventor 杨海涛张瑞刘祥王泽方陈成蔡岩高帆胡灿
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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