37 results about "Polyethylene Glycol Hydrogel" patented technology

The invention discloses a keratin-peptide-modified polyethylene glycol hydrogel, and a preparation method and an application thereof. The keratin-peptide-modified polyethylene glycol hydrogel comprises a copolymer of keratin-peptide-modified polyethylene glycol and polyethylene glycol acrylate monomer. According to the keratin-peptide-modified polyethylene glycol hydrogel provided by the invention, with the good biological performances of natural keratin peptide and the fine regulation capacity of polyethylene glycol hydrogel, the bio-functional material hydrogel product with promotion function upon cell adhesion and growth is obtained.

A method for in situ repair of meniscal injuries comprising induction of meniscal repair and regeneration by introducing an adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury alone, supplemented with a synovial tissue or in conjunction with a support matrix.

The invention discloses a three-dimensional network adhesive for a secondary battery and a preparation method thereof, a negative electrode slurry and a negative electrode material. The adhesive is apolyacrylic acid-polyethylene glycol hydrogel polymeric adhesive having a three-dimensional network structure; the three-dimensional network structure is stable and has excellent mechanical properties, so that the irreversible slip does not occur between a polymer molecular chain and active particles when the three-dimensional network structure is applied to the battery, and the stress generated by the volume expansion of the active material can be effectively borne. In the preparation method of the three-dimensional network adhesive, the raw materials are easy to obtain, the cost is low, andthe repeatability is good, therefore, the preparation method of the three-dimensional network adhesive can be widely applied in actual production; by using the negative electrode slurry and the negative electrode material prepared through the adhesive, the problem of material powdering and electrode structure collapse due to volume expansion and contraction of the active material in the battery electrode during charging and discharging processes is solved; therefore, the capacity attenuation of the battery is relieved, and the cycle stability of the battery is improved.

The invention provides a polyethylene glycol derivative, which comprises a repeating unit with a structure represented by a formula (I) and an end group with a structure represented by a formula (II).The polyethylene glycol derivative provided by the invention has good biocompatibility due to the repeating unit with the structure represented by the formula (I). Due to the fact that the o-phthalaldehyde terminal group with the structure represented by the formula (II) can react with various groups such as amino, (acyl) hydrazine, amido-oxy and the like, the reaction speed is high, and the reaction conditions are mild. The polyethylene glycol derivative provided by the invention and amino-terminated polyethylene glycol are mixed in an aqueous medium to quickly form a chemically cross-linkedhydrogel material, and the chemically cross-linked hydrogel material has the advantages of mild preparation conditions, high gelling speed, high mechanical strength and good stability. The polyethylene glycol hydrogel can be used as a drug sustained-release carrier or a tissue engineering scaffold and the like to be applied to the field of biomedical materials.

The invention discloses injectable hyaluronic acid / polyethylene glycol hydrogel as well as a preparation method and application thereof, and belongs to the fields of plastic and cosmetic biological materials. The method is characterized in that a cyclooctyne-modified hyaluronic acid (HA) solution is mixed with a nitrine-modified polyethylene glycol (PEG) solution, a hydrogel precursor solution with favorable flowability is formed, and the hydrogel precursor solution can be quickly cross-linked through a ring tension promoted click chemical reaction to form the hydrogel after being injected into a body, so as to play roles in water retention, plastic and the like. The preparation process of the material is simple; the additional addition of a cross-linking agent is not needed; the heating is not needed; the ultraviolet treatment or the radiation and the like are not needed; one-step cross-linking is adopted; the injectable hyaluronic acid / polyethylene glycol hydrogel is non-toxic and has no stimulation; therefore, the made hydrogel is good in biocompatibility, and is insignificant in inflammatory reaction. Meanwhile, the gel is slower in degradation speed, and is excellent in mechanical performance; therefore, the material is good in durability and molding performance, is quite applicably used as a face-lifting filling material in the fields of wrinkle resisting, breast enlargement, nose augmentation, filling-padding and the like.

The invention discloses a method for preparing polyethylene glycol hydrogel for orthotopic injection. The method comprises the following steps of: preparing a multi-mercapto linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and thiomalic acid as raw materials and rare earth trifluoromethanesulfonate as a catalyst; preparing a double-bond linear polyethylene glycol polyether ester by polycondensation with polyethylene glycol and maleic anhydride as starting raw materials and rare earth trifluoromethanesulfonate as a catalyst; and dissolving multi-mercapto linear polyethylene glycol polyether ester and multiple double-bond linear polyethylene glycol polyether esters in a phosphate buffered saline (PBS) buffer solution respectively, quickly mixing the two solutions uniformly and standing the mixed solution to obtain the polyethylene glycol hydrogel for orthotopic injection. The method is simple; conditions are easy to control, so that the method is suitable for industrial production. The invention also discloses the polyethylene glycol hydrogel for orthotopic injection, which is degradable.

The invention discloses a dynamic ion cross-linked polyacrylic acid-polyethylene glycol hydrogel binding agent and preparation method and application thereof. The dynamic ion cross-linked polyacrylicacid-polyethylene glycol hydrogel binding agent is prepared by a one-pot method. The binding agent combines favorable conductive iconicity of polyethylene glycol and the performance of acrylic acid capable of polymerization, and a three-dimensional network structure capable of ion conduction can be formed; the three-dimensional network structure of the binding agent can have excellent dynamic performance, and the stress generated by an active material during the charge and discharge process can be effectively reduced; and due to the introduction of dynamic ions, dynamic ions are attached ontothe whole three-dimensional network structure, the whole three-dimensional network has a self-recovery effect, the crack generated by a silicon negative electrode after long-term circulation to induceand generate larger crack in subsequent circulation can be effectively prevented or recovered by the self-recovery function of the binding agent, so that the stability of an electrode structure is maintained.

The invention discloses a method of preparing a polyethylene glycol and protein fiber combined artificial cardiac valve and belongs to the field of biomedical materials. The method comprises: covering egg shell membrane protein fiber with photo-crosslinked polyethylene glycol hydrogel to obtain a composite material, and preparing the composite lamellar artificial cardiac valve through crosslinking by further using a molecular crosslinking agent (such as glutaraldehyde). The polyethylene glycol hydrogel is prepared by means of photo-crosslinking, ensuring the integrity of artificial valve materials, protecting the covered protein fiber from the in-vivo enzymatic decomposition and preventing calcification of the artificial valve. The artificial cardiac valve material prepared by the method simulates the lamellar structure of human aortic valves and has mechanical properties similar to those of the human aortic valves, with good biocompatibility guaranteed, and the need of a replacement receptor for high valve durability, good tissue compatibility and dispensing with a lifetime of anticoagulation can be met.

The invention relates to a preparation method of a polycaprolactone / polyethylene glycol hydrogel used for photodynamic therapy, and belongs to the technical field of photodynamic therapy. The preparation method comprises the steps of (1) preparing porphyrin-core star hydroxyl-terminated polycaprolactone by adding a catalyst of stannous octoate (SnOct2) in a 5,10,15,20-tetra(2-hydroxyethyl)phenyl porphyrin compound to initiate a ring-opening polymerization of epsilon-caprolactone at a temperature of 120 DEG C; (2) preparing porphyrin-core star polycaprolactone-block-polyethylene glycol via an esterification reaction of the porphyrin-core star hydroxyl-terminated polycaprolactone and carboxyl-terminated polyethylene glycol; and (3) dissolving the porphyrin-core star polycaprolactone-block-polyethylene glycol in deionized water, then adding alpha-cyclodextrin, stirring vigorously for 30 min, treating for 5 min by ultrasound, and standing at a temperature of 25 DEG C. The preparation method is mild in conditions, reasonable in design, convenient for operation, and is helpful for application in industrial production.

The invention relates to a polypropylene mesh / electro-spinning nano-fiber membrane as well as a preparation method and an application thereof. The polypropylene mesh / electro-spinning nano-fiber membrane is prepared through the following steps: (1) preparing a chitosan-polyethylene glycol hydrogel; (2) preparing basic fibroblast growth factor (bFGF) embedded polylactic acid-poly lactic-co-glycolic acid (PLGA) microspheres; (3) preparing an electro-spinning solution; (4) preparing the polypropylene mesh / electro-spinning nano-fiber membrane by use of an electro-spinning method. According to the polypropylene mesh / electro-spinning nano-fiber membrane, the polypropylene mesh and the nano-fiber membrane are compounded creatively, and therefore, the biocompatibility of the polypropylene mesh is improved by use of the nano-fiber membrane and the tensile strength of the nano-fiber membrane is improved by use of the polypropylene mesh, and the polypropylene mesh and the nano-fiber membrane supplement each other; in addition, the microspheres are introduced to realize controlled drug release; as a result, lots of defects of the clinical existing polypropylene meshes can be overcome.

The invention prepares an interventional cardiac valve prosthesis based on anisotropic polymer fiber composite material valve leaflets. Anisotropic polymer fiber cloth is seamed in a metal stent, so that a self-expanded (such as nickle-titanium alloy stent material) or self-expanded (such as cobalt-chromium alloy stent material) interventional valve stent prosthesis is prepared; and photo-crosslinking or chemical crosslinking polyethylene glycol hydrogel covers the surface of the polymer fiber material. The interventional cardiac valve prosthesis provided by the invention, which is prepared from polymer fiber cloth having anisotropic mechanical performance, such as polyester, polyurethane, polytetrafluoroethylene or a composite material thereof, can simulate a stress distribution state ofa human body aortic valve under a blood flow effect, so that mechanical performance, which is similar to that of human body valve, can be achieved, and subsequently, the fatigue resistance of the valve leaflets can be improved. In addition, by combining the polyethylene glycol hydrogel on the surface, the integration of the valve leaflet material is guaranteed, and moreover, an anti-fouling function is achieved; platelet adhesion and protein adsorption can be relieved; and good bio-compatibility can be achieved.

The invention provides novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel. The hydrogel is a product prepared by carrying out click chemical reaction of azido-alkynyl on a four-arm poly(D,L-lactide-co-glycolide)-polyethylene glycol-azido co-polymer and four-arm alkynyl; the hydrogel prepared by the method can be used for controlling gelling time through changing the concentration ofraw materials; the hydrogel has good biocompatibility and is a relatively ideal medical controlled release material and a cell loading material. The azido-alkynyl click chemical reaction is utilized,the selectivity of the reaction is high, reaction conditions are moderate and the reaction temperature is relatively wide; meanwhile, the hydrogel produced by the method has good stability in a shortperiod and can be degraded through a hydrolysis manner after a long period.

The invention discloses a composite material based on silk fibroin fiber and heart valve prosthesis, and belongs to the technical field of medical materials. Prosthetic valve leaflets are prepared from the silk fibroin fiber with an electrospinning technology, and silk fibroin membrane material valve leaflets with isotropy and anisotropy mechanical properties can be prepared by electrospinning according to different collecting modes respectively. Besides, the surface of a silk fibroin fiber membrane can be coated with polyethylene glycol hydrogel with a photo-crosslinking method, and therefore, the composite material is formed. A space grid structure of the polyethylene glycol hydrogel protects silk fibroin from being degraded by bio-enzyme, and the polyethylene glycol hydrogel has an antifouling function. Anisotropic silk fibroin membrane prepared by electrospinning has mechanical anisotropy, can simulate the stress distribution state of a human aortic valve under the action of blood flow, and has mechanical properties close to those of a human valve.

The invention relates to the technical field of biological medicine, in particular to chitosan / polyethylene glycol hydrogel and a preparation method and use thereof. The hydrogel is obtained by reacting four-arm polyethylene glycol active ester with primary amine in chitosan molecules to generate amido bonds. A structure of the four-arm polyethylene glycol active ester is as follows: a structure of the chitosan molecule is as follows: the prepared hydrogel has a three-dimensional network porous structure and has a good water absorption swelling performance in an acid environment (pH at a wound is slightly acidic), and thus has potentials of promoting drug release and promoting wound healing. The chitosan and the four-arm polyethylene glycol active ester are chemically crosslinked to form the amido bonds, such that the prepared hydrogel has an excellent mechanical strength and a compression strength reaching 440 kPa, and can be used as an ideal material for a tooth extraction site preservation technology. Polyhexamethylene guanidine hydrochloride is loaded in the hydrogel material, such that an antimicrobial property of the hydrogel is enhanced, and the hydrogel can be used to the field of tooth extraction cavity wound dressings.

The invention discloses a polyethylene glycol hydrogel material and a preparing method thereof. The preparing method includes the steps that under the condition that a catalyst exists, polyethylene glycol, and the raw material obtained in the mode that a polyhydroxy compound and divinyl sulfone are mixed to be even is reacted to form gel. In the preparing method, hydroxyl-terminated polyethylene glycol serves as a raw material, the divinyl sulfone serves as a cross-linking agent, the polyhydroxy compound is added, the network structure is formed, and a one-step reaction is carried out at the room temperature under the catalyst condition. The method is simple, and adjustment of mechanical performance of hydrogel can be achieved by controlling the species and the proportion of the polyhydroxy compound and the chain length of the polyethylene glycol; solvent selection is wide, the polyethylene glycol hydrogel material is suitable for multiple hydroxyl-compound raw materials, and the hydrogel material meeting the requirements is further obtained.

The invention discloses a polycaprolactone diacrylate / polyethylene glycol hydrogel stent and a preparation method and application thereof. Polyethylene glycol serves as a hydrophilic block, and polycaprolactone diacrylate serves as a hydrophobic block; the mass ratio of the polyethylene glycol to the polycaprolactone diacrylate is (3-7):(3-7); the interior of polycaprolactone diacrylate / polyethylene glycol hydrogel is of a porous structure, and the pore size is 40-110 microns; the hydrogel stent is internally porous and has good elasticity, degradability and biocompatibility, the porous structure can be used for drug delivery and tissue engineering, and cells in cell embedding and growth can be uniformly inoculated into the stent without pretreatment. The polycaprolactone diacrylate / polyethylene glycol hydrogel stent has the advantages that due to the addition of the polycaprolactone diacrylate, the high crystallinity and hydrophobicity of the polyethylene glycol chain segment are improved, the viscosity of the hydrogel in the sol state is reduced, and the stent has good application prospects.

The present invention relates to a polyethylene glycol hydrogel injection, and, more particularly, to an injection to be administered into a joint (a synovial joint cavity) for the improvement of symptoms of arthritis by containing two separate buffer solutions, wherein a solution (1) contains a polyethylene glycol derivative with an electrophilic functional group and a buffer of pH 3.5 to 6, and a solution (2) contains a polyethylene glycol derivative with a nucleophilic functional group, hyaluronic acid, and a buffer of pH 7.5 to 11. The injection of the present invention is highly biocompatible and long-lasting in the joint, showing the efficacy of pain relief, cartilage protection, and inhibition of inflammation, thus offering the effective prevention and treatment of arthritis.

The invention discloses a preparation method of polyethylene glycol hydrogel and belongs to the technical field of hydrogel. According to the method, polyethylene glycol is taken as a raw material and is subjected to esterification with cysteine, multi-mercapto linear polyethylene glycol ester is produced, multi-mercapto linear polyethylene glycol ester and citric anhydride are subjected to condensation polymerization under the catalysis of trifluoromethane sulfonic acid rare earth to produce multi-double-bond linear polyethylene glycol type polyether ester, then, multi-mercapto linear polyethylene glycol ester and multi-double-bond linear polyethylene glycol type polyether ester are mixed and subjected to an addition reaction through mercapto-double bond Michael, hydrogel is prepared, glycosidase and esterase are added at the low temperature, the mixture is stored at the low temperature, the activity of enzymes is inhibited at the low temperature, enzymes are in high activity at the temperature of a human body after hydrogel enters the human body, hydrogel is hydrolyzed, molecules which can be absorbed or degraded by the human body are produced, and degradation of hydrogel is accelerated due to addition of the enzymes. The method is simple to operate and easy to industrialize.

The invention relates to a polypropylene mesh sheet / electrospinning nanofiber membrane and a preparation method and application thereof. The polypropylene mesh / electrospun nanofibrous membrane was prepared by the following steps: 1) preparation of chitosan‐polyethylene glycol hydrogel; 2) preparation of polylactic acid‐glycolic acid copolymer embedded with basic fibroblast factor bFGF PLGA microspheres; 3) preparation of electrospinning solution; 4) preparation of polypropylene mesh / electrospinning nanofiber membrane by electrospinning. The invention creatively combines the polypropylene mesh with the nanofiber membrane, uses the nanofiber membrane to improve the biocompatibility of the polypropylene mesh, and uses the polypropylene mesh to improve the tensile strength of the nanofiber membrane, the two complement each other, and then The introduction of microspheres to achieve controlled release of drugs can fill in many deficiencies of the existing clinical polypropylene mesh.

The invention discloses zwitterionic hyperbranched polyether hydrogel with high anti-fouling performance as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) synthesizing a betaine zwitterionic monomer containing double bonds; (2) synthesizing functionally modified multi-arm polyethylene glycol; (3) synthesizing hyperbranched polyethylene glycol containing betaine zwitterions; and (4) constructing hyperbranched polyethylene glycol hydrogel containing the betaine zwitterions. A hydrogel carrier material prepared by the method has excellent anti-fouling performance, can efficiently prevent biomolecules, cells and the like from being in contact with gel, can achieve low-concentration rapid in-situ gel forming at the same time, thenshows excellent biocompatibility and stability, is similar to natural vitreous bodies in performance, and effectively meets the requirements for long-term stability and biocompatibility of the vitreous bodies for clinical operations.

The invention discloses a preparation method and application of hydrogel based on poly-N-PPG-PEG, the preparation method comprises the steps that firstly, a poly-N-PPG-PEG nano-composite is prepared,then PPG-PEG nano-composite powder and cyclodextrin (alpha-CD) are prepared into aqueous solutions with certain concentrations respectively, the aqueous solutions are mixed uniformly and stood at theroom temperature for a period of time, and the poly-N-PPG-PEG is prepared. The ultraviolet absorption peak of the prepared hydrogel is shifted to a near-infrared second window, the laser penetration depth can be increased through laser radiation of the near-infrared second window, the absorption of laser by a living tissue is reduced, and damage to the normal tissue is reduced. The hydrogel is injectable type intelligent hydrogel with temperature and shear sensitivity double response, can load chemotherapy drugs so that the drugs can be released at fixed points as required, and belongs to thephoto-thermal hydrogel carrying system for enhancing chemotherapy and photo-thermal combined treatment.

The invention discloses a preparation method of an injectable polyethylene glycol preparation loaded with alendronate sodium and an application thereof. The preparation at least comprises two independent solutions, wherein a solution 1 is prepared from four-arm-polyethylene glycol-aldehyde group; a solution 2 containsg four arms-polyethylene glycol-amino groups; the hydrogel is dissolved in the solution 1 or the solution 2, or is independently dissolved to form a solution 3; wherein the pH value of the mixed solution of the preparation obtained by mixing the solutions is 4.0-9.0. The four-arm-polyethylene glycol-aldehyde groups and four-arm-polyethylene glycol-amino groups are adopted for in-situ gelling through Schiff base bonds, intraoperative operation is convenient, and the gelling speed is high. Meanwhile, amino on collagen on the surface of the tissue and alendronate sodium in the solution can be quickly and chemically bonded with the four-arm-polyethylene glycol-aldehyde group through a Schiff base bond.

The invention discloses a method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel. The method includes the steps of (1), preparing acylation polyethylene glycol; (2), preparing acylation polypeptide; (3), separating human mesenchymal stem cells; (4), performing induced differentiation on the mesenchymal stem cells to obtain chondrocytes. The method for enhancing the biocompatibility and degradability is advanced in technique, simple in steps, simple to operate, and capable of promoting the biocompatibility and degradability of a biomaterial stent and promoting cell reproduction and tissue regeneration.

The invention discloses a method of preparing a polyethylene glycol and protein fiber combined artificial cardiac valve and belongs to the field of biomedical materials. The method comprises: covering egg shell membrane protein fiber with photo-crosslinked polyethylene glycol hydrogel to obtain a composite material, and preparing the composite lamellar artificial cardiac valve through crosslinking by further using a molecular crosslinking agent (such as glutaraldehyde). The polyethylene glycol hydrogel is prepared by means of photo-crosslinking, ensuring the integrity of artificial valve materials, protecting the covered protein fiber from the in-vivo enzymatic decomposition and preventing calcification of the artificial valve. The artificial cardiac valve material prepared by the method simulates the lamellar structure of human aortic valves and has mechanical properties similar to those of the human aortic valves, with good biocompatibility guaranteed, and the need of a replacement receptor for high valve durability, good tissue compatibility and dispensing with a lifetime of anticoagulation can be met.

The invention discloses an organosilicon polyethylene glycol hydrogel material with a self-healing characteristic and a preparation method thereof. Amino-terminated polyethylene glycol, amino siliconeoil, N, N '-carbonyl diimidazole and N, N'-thiocarbonyl diimidazole are reacted to prepare the organosilicon / polyethylene glycol hydrogel material containingurea groups and / orthiourea groups, so thatthe hydrogel material is endowed with a relatively good self-repairing function. Based on the water dispersibility of the amino silicon oil, in the whole process, an aqueous solution is adopted for reaction, so that the low-cost and environment-friendly preparation of the organosilicon-based hydrogel is realized; the organosilicon / polyethylene glycol hydrogel material prepared by the method is good in biocompatibility and simple in preparation process.

The invention provides an application of polyethylene glycol hydrogel in preparation of a self-adhesive biomedical material. The polyethylene glycol hydrogel is formed by crosslinking aldehyde-terminated star-shaped multi-arm polyethylene glycol and polylysine. Research finds that the polyethylene glycol hydrogel film can realize self-adhesion of the hydrogel film through reaction of residual aldehyde groups on the surface and amino groups and related non-covalent interaction, and the hydrogel film can be further processed into complex shapes such as a hollow tube and the like through the self-adhesion effect. The polyethylene glycol hydrogel can be freely formed in the operation process, the self-adhesive film can wrap or support tissue, and the polyethylene glycol hydrogel has important application potential in the fields of tissue adhesion prevention, tissue engineering scaffolds and the like.

The invention discloses a preparation method and application of hydrogel based on poly-N-PPG-PEG, the preparation method comprises the steps that firstly, a poly-N-PPG-PEG nano-composite is prepared,then PPG-PEG nano-composite powder and cyclodextrin (alpha-CD) are prepared into aqueous solutions with certain concentrations respectively, the aqueous solutions are mixed uniformly and stood at theroom temperature for a period of time, and the poly-N-PPG-PEG is prepared. The ultraviolet absorption peak of the prepared hydrogel is shifted to a near-infrared second window, the laser penetration depth can be increased through laser radiation of the near-infrared second window, the absorption of laser by a living tissue is reduced, and damage to the normal tissue is reduced. The hydrogel is injectable type intelligent hydrogel with temperature and shear sensitivity double response, can load chemotherapy drugs so that the drugs can be released at fixed points as required, and belongs to thephoto-thermal hydrogel carrying system for enhancing chemotherapy and photo-thermal combined treatment.

The present invention provides a polyethylene glycol derivative, comprising a repeating unit having a structure of formula (I) and an end group having a structure of formula (II). The polyethylene glycol derivative provided by the present invention has good biocompatibility due to the repeating unit of the structure of formula (I). Because the end group of o-phthalaldehyde having the structure of formula (II) can react with various groups such as amino group, (hydrazine) group, aminooxy group, etc., the reaction rate is fast and the reaction conditions are mild. Mixing the polyethylene glycol derivative provided by the invention with the polyethylene glycol containing amino groups at the end group in an aqueous medium can quickly form a chemically cross-linked hydrogel material, which has mild preparation conditions, fast gelation speed, and high mechanical strength. High, good stability. The polyethylene glycol hydrogel can be used in the field of biomedical materials as a slow-release drug carrier or a tissue engineering scaffold.

The invention discloses injectable hyaluronic acid / polyethylene glycol hydrogel as well as a preparation method and application thereof, and belongs to the fields of plastic and cosmetic biological materials. The method is characterized in that a cyclooctyne-modified hyaluronic acid (HA) solution is mixed with a nitrine-modified polyethylene glycol (PEG) solution, a hydrogel precursor solution with favorable flowability is formed, and the hydrogel precursor solution can be quickly cross-linked through a ring tension promoted click chemical reaction to form the hydrogel after being injected into a body, so as to play roles in water retention, plastic and the like. The preparation process of the material is simple; the additional addition of a cross-linking agent is not needed; the heating is not needed; the ultraviolet treatment or the radiation and the like are not needed; one-step cross-linking is adopted; the injectable hyaluronic acid / polyethylene glycol hydrogel is non-toxic and has no stimulation; therefore, the made hydrogel is good in biocompatibility, and is insignificant in inflammatory reaction. Meanwhile, the gel is slower in degradation speed, and is excellent in mechanical performance; therefore, the material is good in durability and molding performance, is quite applicably used as a face-lifting filling material in the fields of wrinkle resisting, breast enlargement, nose augmentation, filling-padding and the like.

The invention relates to the technical field of biomedicine, in particular to a chitosan / polyethylene glycol hydrogel and a preparation method and application thereof. The hydrogel is obtained by reacting the four-arm polyethylene glycol active ester with the primary amine in the chitosan molecule to generate an amide bond; the structure of the four-arm polyethylene glycol active ester is as follows: the structure of the chitosan molecule is as follows: prepared The hydrogel has a three-dimensional network porous structure, and has good water absorption and swelling properties in an acidic environment (the pH of the wound is slightly acidic), so that the prepared hydrogel has the application potential of promoting drug release and wound healing. Chitosan and four-armed polyethylene glycol active ester are chemically cross-linked to form amide bonds, which makes the prepared hydrogel have excellent mechanical strength, with a compressive strength of 440kPa, which can be used as an ideal material for tooth extraction site preservation technology. By loading polyhexamethyleneguanidine hydrochloride in the hydrogel material, the antibacterial performance of the hydrogel is enhanced, and the hydrogel can be applied to the field of tooth extraction socket wound dressing.