37 results about "Polyethylene Glycol Hydrogel" patented technology

The invention discloses a method of preparing a polyethylene glycol and protein fiber combined artificial cardiac valve and belongs to the field of biomedical materials. The method comprises: covering egg shell membrane protein fiber with photo-crosslinked polyethylene glycol hydrogel to obtain a composite material, and preparing the composite lamellar artificial cardiac valve through crosslinking by further using a molecular crosslinking agent (such as glutaraldehyde). The polyethylene glycol hydrogel is prepared by means of photo-crosslinking, ensuring the integrity of artificial valve materials, protecting the covered protein fiber from the in-vivo enzymatic decomposition and preventing calcification of the artificial valve. The artificial cardiac valve material prepared by the method simulates the lamellar structure of human aortic valves and has mechanical properties similar to those of the human aortic valves, with good biocompatibility guaranteed, and the need of a replacement receptor for high valve durability, good tissue compatibility and dispensing with a lifetime of anticoagulation can be met.

The invention discloses a preparation method and application of hydrogel based on poly-N-PPG-PEG, the preparation method comprises the steps that firstly, a poly-N-PPG-PEG nano-composite is prepared,then PPG-PEG nano-composite powder and cyclodextrin (alpha-CD) are prepared into aqueous solutions with certain concentrations respectively, the aqueous solutions are mixed uniformly and stood at theroom temperature for a period of time, and the poly-N-PPG-PEG is prepared. The ultraviolet absorption peak of the prepared hydrogel is shifted to a near-infrared second window, the laser penetration depth can be increased through laser radiation of the near-infrared second window, the absorption of laser by a living tissue is reduced, and damage to the normal tissue is reduced. The hydrogel is injectable type intelligent hydrogel with temperature and shear sensitivity double response, can load chemotherapy drugs so that the drugs can be released at fixed points as required, and belongs to thephoto-thermal hydrogel carrying system for enhancing chemotherapy and photo-thermal combined treatment.

The invention discloses injectable hyaluronic acid / polyethylene glycol hydrogel as well as a preparation method and application thereof, and belongs to the fields of plastic and cosmetic biological materials. The method is characterized in that a cyclooctyne-modified hyaluronic acid (HA) solution is mixed with a nitrine-modified polyethylene glycol (PEG) solution, a hydrogel precursor solution with favorable flowability is formed, and the hydrogel precursor solution can be quickly cross-linked through a ring tension promoted click chemical reaction to form the hydrogel after being injected into a body, so as to play roles in water retention, plastic and the like. The preparation process of the material is simple; the additional addition of a cross-linking agent is not needed; the heating is not needed; the ultraviolet treatment or the radiation and the like are not needed; one-step cross-linking is adopted; the injectable hyaluronic acid / polyethylene glycol hydrogel is non-toxic and has no stimulation; therefore, the made hydrogel is good in biocompatibility, and is insignificant in inflammatory reaction. Meanwhile, the gel is slower in degradation speed, and is excellent in mechanical performance; therefore, the material is good in durability and molding performance, is quite applicably used as a face-lifting filling material in the fields of wrinkle resisting, breast enlargement, nose augmentation, filling-padding and the like.