37 results about "Polyethylene Glycol Hydrogel" patented technology

The invention discloses a keratin-peptide-modified polyethylene glycol hydrogel, and a preparation method and an application thereof. The keratin-peptide-modified polyethylene glycol hydrogel comprises a copolymer of keratin-peptide-modified polyethylene glycol and polyethylene glycol acrylate monomer. According to the keratin-peptide-modified polyethylene glycol hydrogel provided by the invention, with the good biological performances of natural keratin peptide and the fine regulation capacity of polyethylene glycol hydrogel, the bio-functional material hydrogel product with promotion function upon cell adhesion and growth is obtained.

The invention provides a polyethylene glycol derivative, which comprises a repeating unit with a structure represented by a formula (I) and an end group with a structure represented by a formula (II).The polyethylene glycol derivative provided by the invention has good biocompatibility due to the repeating unit with the structure represented by the formula (I). Due to the fact that the o-phthalaldehyde terminal group with the structure represented by the formula (II) can react with various groups such as amino, (acyl) hydrazine, amido-oxy and the like, the reaction speed is high, and the reaction conditions are mild. The polyethylene glycol derivative provided by the invention and amino-terminated polyethylene glycol are mixed in an aqueous medium to quickly form a chemically cross-linkedhydrogel material, and the chemically cross-linked hydrogel material has the advantages of mild preparation conditions, high gelling speed, high mechanical strength and good stability. The polyethylene glycol hydrogel can be used as a drug sustained-release carrier or a tissue engineering scaffold and the like to be applied to the field of biomedical materials.

The invention discloses a dynamic ion cross-linked polyacrylic acid-polyethylene glycol hydrogel binding agent and preparation method and application thereof. The dynamic ion cross-linked polyacrylicacid-polyethylene glycol hydrogel binding agent is prepared by a one-pot method. The binding agent combines favorable conductive iconicity of polyethylene glycol and the performance of acrylic acid capable of polymerization, and a three-dimensional network structure capable of ion conduction can be formed; the three-dimensional network structure of the binding agent can have excellent dynamic performance, and the stress generated by an active material during the charge and discharge process can be effectively reduced; and due to the introduction of dynamic ions, dynamic ions are attached ontothe whole three-dimensional network structure, the whole three-dimensional network has a self-recovery effect, the crack generated by a silicon negative electrode after long-term circulation to induceand generate larger crack in subsequent circulation can be effectively prevented or recovered by the self-recovery function of the binding agent, so that the stability of an electrode structure is maintained.

The invention discloses a method of preparing a polyethylene glycol and protein fiber combined artificial cardiac valve and belongs to the field of biomedical materials. The method comprises: covering egg shell membrane protein fiber with photo-crosslinked polyethylene glycol hydrogel to obtain a composite material, and preparing the composite lamellar artificial cardiac valve through crosslinking by further using a molecular crosslinking agent (such as glutaraldehyde). The polyethylene glycol hydrogel is prepared by means of photo-crosslinking, ensuring the integrity of artificial valve materials, protecting the covered protein fiber from the in-vivo enzymatic decomposition and preventing calcification of the artificial valve. The artificial cardiac valve material prepared by the method simulates the lamellar structure of human aortic valves and has mechanical properties similar to those of the human aortic valves, with good biocompatibility guaranteed, and the need of a replacement receptor for high valve durability, good tissue compatibility and dispensing with a lifetime of anticoagulation can be met.

The invention relates to a polypropylene mesh/electro-spinning nano-fiber membrane as well as a preparation method and an application thereof. The polypropylene mesh/electro-spinning nano-fiber membrane is prepared through the following steps: (1) preparing a chitosan-polyethylene glycol hydrogel; (2) preparing basic fibroblast growth factor (bFGF) embedded polylactic acid-poly lactic-co-glycolic acid (PLGA) microspheres; (3) preparing an electro-spinning solution; (4) preparing the polypropylene mesh/electro-spinning nano-fiber membrane by use of an electro-spinning method. According to the polypropylene mesh/electro-spinning nano-fiber membrane, the polypropylene mesh and the nano-fiber membrane are compounded creatively, and therefore, the biocompatibility of the polypropylene mesh is improved by use of the nano-fiber membrane and the tensile strength of the nano-fiber membrane is improved by use of the polypropylene mesh, and the polypropylene mesh and the nano-fiber membrane supplement each other; in addition, the microspheres are introduced to realize controlled drug release; as a result, lots of defects of the clinical existing polypropylene meshes can be overcome.

The invention provides novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel. The hydrogel is a product prepared by carrying out click chemical reaction of azido-alkynyl on a four-arm poly(D,L-lactide-co-glycolide)-polyethylene glycol-azido co-polymer and four-arm alkynyl; the hydrogel prepared by the method can be used for controlling gelling time through changing the concentration ofraw materials; the hydrogel has good biocompatibility and is a relatively ideal medical controlled release material and a cell loading material. The azido-alkynyl click chemical reaction is utilized,the selectivity of the reaction is high, reaction conditions are moderate and the reaction temperature is relatively wide; meanwhile, the hydrogel produced by the method has good stability in a shortperiod and can be degraded through a hydrolysis manner after a long period.

The invention discloses a composite material based on silk fibroin fiber and heart valve prosthesis, and belongs to the technical field of medical materials. Prosthetic valve leaflets are prepared from the silk fibroin fiber with an electrospinning technology, and silk fibroin membrane material valve leaflets with isotropy and anisotropy mechanical properties can be prepared by electrospinning according to different collecting modes respectively. Besides, the surface of a silk fibroin fiber membrane can be coated with polyethylene glycol hydrogel with a photo-crosslinking method, and therefore, the composite material is formed. A space grid structure of the polyethylene glycol hydrogel protects silk fibroin from being degraded by bio-enzyme, and the polyethylene glycol hydrogel has an antifouling function. Anisotropic silk fibroin membrane prepared by electrospinning has mechanical anisotropy, can simulate the stress distribution state of a human aortic valve under the action of blood flow, and has mechanical properties close to those of a human valve.

The invention relates to the technical field of biological medicine, in particular to chitosan/polyethylene glycol hydrogel and a preparation method and use thereof. The hydrogel is obtained by reacting four-arm polyethylene glycol active ester with primary amine in chitosan molecules to generate amido bonds. A structure of the four-arm polyethylene glycol active ester is as follows: a structure of the chitosan molecule is as follows: the prepared hydrogel has a three-dimensional network porous structure and has a good water absorption swelling performance in an acid environment (pH at a wound is slightly acidic), and thus has potentials of promoting drug release and promoting wound healing. The chitosan and the four-arm polyethylene glycol active ester are chemically crosslinked to form the amido bonds, such that the prepared hydrogel has an excellent mechanical strength and a compression strength reaching 440 kPa, and can be used as an ideal material for a tooth extraction site preservation technology. Polyhexamethylene guanidine hydrochloride is loaded in the hydrogel material, such that an antimicrobial property of the hydrogel is enhanced, and the hydrogel can be used to the field of tooth extraction cavity wound dressings.

The invention discloses a polycaprolactone diacrylate/polyethylene glycol hydrogel stent and a preparation method and application thereof. Polyethylene glycol serves as a hydrophilic block, and polycaprolactone diacrylate serves as a hydrophobic block; the mass ratio of the polyethylene glycol to the polycaprolactone diacrylate is (3-7):(3-7); the interior of polycaprolactone diacrylate/polyethylene glycol hydrogel is of a porous structure, and the pore size is 40-110 microns; the hydrogel stent is internally porous and has good elasticity, degradability and biocompatibility, the porous structure can be used for drug delivery and tissue engineering, and cells in cell embedding and growth can be uniformly inoculated into the stent without pretreatment. The polycaprolactone diacrylate/polyethylene glycol hydrogel stent has the advantages that due to the addition of the polycaprolactone diacrylate, the high crystallinity and hydrophobicity of the polyethylene glycol chain segment are improved, the viscosity of the hydrogel in the sol state is reduced, and the stent has good application prospects.

The present invention relates to a polyethylene glycol hydrogel injection, and, more particularly, to an injection to be administered into a joint (a synovial joint cavity) for the improvement of symptoms of arthritis by containing two separate buffer solutions, wherein a solution (1) contains a polyethylene glycol derivative with an electrophilic functional group and a buffer of pH 3.5 to 6, and a solution (2) contains a polyethylene glycol derivative with a nucleophilic functional group, hyaluronic acid, and a buffer of pH 7.5 to 11. The injection of the present invention is highly biocompatible and long-lasting in the joint, showing the efficacy of pain relief, cartilage protection, and inhibition of inflammation, thus offering the effective prevention and treatment of arthritis.

The invention discloses a preparation method of polyethylene glycol hydrogel and belongs to the technical field of hydrogel. According to the method, polyethylene glycol is taken as a raw material and is subjected to esterification with cysteine, multi-mercapto linear polyethylene glycol ester is produced, multi-mercapto linear polyethylene glycol ester and citric anhydride are subjected to condensation polymerization under the catalysis of trifluoromethane sulfonic acid rare earth to produce multi-double-bond linear polyethylene glycol type polyether ester, then, multi-mercapto linear polyethylene glycol ester and multi-double-bond linear polyethylene glycol type polyether ester are mixed and subjected to an addition reaction through mercapto-double bond Michael, hydrogel is prepared, glycosidase and esterase are added at the low temperature, the mixture is stored at the low temperature, the activity of enzymes is inhibited at the low temperature, enzymes are in high activity at the temperature of a human body after hydrogel enters the human body, hydrogel is hydrolyzed, molecules which can be absorbed or degraded by the human body are produced, and degradation of hydrogel is accelerated due to addition of the enzymes. The method is simple to operate and easy to industrialize.

The invention discloses zwitterionic hyperbranched polyether hydrogel with high anti-fouling performance as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) synthesizing a betaine zwitterionic monomer containing double bonds; (2) synthesizing functionally modified multi-arm polyethylene glycol; (3) synthesizing hyperbranched polyethylene glycol containing betaine zwitterions; and (4) constructing hyperbranched polyethylene glycol hydrogel containing the betaine zwitterions. A hydrogel carrier material prepared by the method has excellent anti-fouling performance, can efficiently prevent biomolecules, cells and the like from being in contact with gel, can achieve low-concentration rapid in-situ gel forming at the same time, thenshows excellent biocompatibility and stability, is similar to natural vitreous bodies in performance, and effectively meets the requirements for long-term stability and biocompatibility of the vitreous bodies for clinical operations.

The invention discloses a preparation method of an injectable polyethylene glycol preparation loaded with alendronate sodium and an application thereof. The preparation at least comprises two independent solutions, wherein a solution 1 is prepared from four-arm-polyethylene glycol-aldehyde group; a solution 2 containsg four arms-polyethylene glycol-amino groups; the hydrogel is dissolved in the solution 1 or the solution 2, or is independently dissolved to form a solution 3; wherein the pH value of the mixed solution of the preparation obtained by mixing the solutions is 4.0-9.0. The four-arm-polyethylene glycol-aldehyde groups and four-arm-polyethylene glycol-amino groups are adopted for in-situ gelling through Schiff base bonds, intraoperative operation is convenient, and the gelling speed is high. Meanwhile, amino on collagen on the surface of the tissue and alendronate sodium in the solution can be quickly and chemically bonded with the four-arm-polyethylene glycol-aldehyde group through a Schiff base bond.

The invention discloses an organosilicon polyethylene glycol hydrogel material with a self-healing characteristic and a preparation method thereof. Amino-terminated polyethylene glycol, amino siliconeoil, N, N '-carbonyl diimidazole and N, N'-thiocarbonyl diimidazole are reacted to prepare the organosilicon/polyethylene glycol hydrogel material containingurea groups and/orthiourea groups, so thatthe hydrogel material is endowed with a relatively good self-repairing function. Based on the water dispersibility of the amino silicon oil, in the whole process, an aqueous solution is adopted for reaction, so that the low-cost and environment-friendly preparation of the organosilicon-based hydrogel is realized; the organosilicon/polyethylene glycol hydrogel material prepared by the method is good in biocompatibility and simple in preparation process.

The invention provides an application of polyethylene glycol hydrogel in preparation of a self-adhesive biomedical material. The polyethylene glycol hydrogel is formed by crosslinking aldehyde-terminated star-shaped multi-arm polyethylene glycol and polylysine. Research finds that the polyethylene glycol hydrogel film can realize self-adhesion of the hydrogel film through reaction of residual aldehyde groups on the surface and amino groups and related non-covalent interaction, and the hydrogel film can be further processed into complex shapes such as a hollow tube and the like through the self-adhesion effect. The polyethylene glycol hydrogel can be freely formed in the operation process, the self-adhesive film can wrap or support tissue, and the polyethylene glycol hydrogel has important application potential in the fields of tissue adhesion prevention, tissue engineering scaffolds and the like.