Preparation method of polyethylene glycol hydrogel

Abstract

The invention discloses a preparation method of polyethylene glycol hydrogel and belongs to the technical field of hydrogel. According to the method, polyethylene glycol is taken as a raw material and is subjected to esterification with cysteine, multi-mercapto linear polyethylene glycol ester is produced, multi-mercapto linear polyethylene glycol ester and citric anhydride are subjected to condensation polymerization under the catalysis of trifluoromethane sulfonic acid rare earth to produce multi-double-bond linear polyethylene glycol type polyether ester, then, multi-mercapto linear polyethylene glycol ester and multi-double-bond linear polyethylene glycol type polyether ester are mixed and subjected to an addition reaction through mercapto-double bond Michael, hydrogel is prepared, glycosidase and esterase are added at the low temperature, the mixture is stored at the low temperature, the activity of enzymes is inhibited at the low temperature, enzymes are in high activity at the temperature of a human body after hydrogel enters the human body, hydrogel is hydrolyzed, molecules which can be absorbed or degraded by the human body are produced, and degradation of hydrogel is accelerated due to addition of the enzymes. The method is simple to operate and easy to industrialize.

Description

technical field [0001] The invention discloses a preparation method of polyethylene glycol hydrogel, which belongs to the field of hydrogel technology. Background technique [0002] Realizing the controlled release of drugs in human diseased parts is an ideal method for treating diseases. Embedding or binding drugs to polymer carriers can achieve controlled release of drugs. The main polymer carriers include polymer micelles, drug / polymer conjugates, gels, etc. In the late 1950s, polymer materials such as silicone rubber and poly(vinyl acetate) were used as carriers of small-molecule drugs to achieve sustained and stable release of drugs. However, these polymer materials are not degradable. After the drug release is completed, these carriers need to be removed through surgery, which increases the pain of the patient. Subsequently, in the 1970s, degradable polymer materials represented by poly(lactide and lactide) were developed as drug carriers, and luteinizing hormone-re...

AI Technical Summary

Problems solved by technology

[0004] The technical problem mainly solved by the present invention: Aiming at the problems that the synthesis conditions of polyethylene glycol are harsh, difficult to be industrialized, expensive, further chemical modification is required, and it is not degradable, a polyethylene glycol-type hydrogel is provided. The preparation method, the present invention uses polyethylene glycol as a raw material to generate polymercapto linear polyethylene glycol ester through esterification with cysteine, and polycondenses with citric anhydride under the catalysis of trifluoromethanesulfonic acid rare earth to generate multiple double bonds The linear polyethylene glycol type polyether ester is then mixed with the two through the mercapto-double bond Michael addition reaction to prepare a hydrogel, add glycosidase and esterase at low temperature, and store at low temperature, low temperature inhibits the activity of the enzyme, After the hydrogel enters the human body, the enzyme generates high activity at the temperature of the human body, hydrolyzes the hydrogel, and produces molecules that can be absorbed by the human body or degradable. The addition of the enzyme accelerates the degradation of the hydrogel, and the invention is simple to operate , easy to realize industrialization