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Zwitterionic hyperbranched polyether hydrogel with high stain resistance as well as preparation method and application thereof

A technology of hyperbranched polyether and zwitterions, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of insufficient antifouling performance and poor stability of hydrogel, and achieve excellent antifouling performance and excellent biocompatibility Performance and stability, the effect of meeting the needs of long-term stability and biocompatibility

Inactive Publication Date: 2020-07-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a zwitterionic hyperbranched polyether hydrogel with high anti-fouling performance and its preparation method and application, which can effectively realize in-situ gelation and solve the problems of existing hydrogels. Poor stability and insufficient antifouling performance

Method used

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  • Zwitterionic hyperbranched polyether hydrogel with high stain resistance as well as preparation method and application thereof
  • Zwitterionic hyperbranched polyether hydrogel with high stain resistance as well as preparation method and application thereof
  • Zwitterionic hyperbranched polyether hydrogel with high stain resistance as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0032] A preparation method of zwitterionic hyperbranched polyethylene glycol hydrogel with high antifouling performance, comprising the following steps:

[0033] (1) Synthesis of double bond-containing carboxybetaine zwitterionic monomer (CBMA)

[0034] Dissolve N-(N,N'-dimethylaminopropyl)acrylamide (DMAPAA, 4.0g, 25.6mmol) in 10mL of anhydrous acetone, and then add β-propiolactone monomer (2g, 27.8mmol) Dissolve it in 10mL of anhydrous acetone, and slowly add it dropwise to the acetone solution of DMAPAA under the stirring condition of 500r / min, and continue to react at room temperature for 24h under the protection of nitrogen. After washing three times and drying in vacuum, the double bond-containing zwitterionic monomer CBMA was obtained, and its chemical reaction formula is shown below.

[0035]

[0036] (2) Synthesis of functional modified multi-arm polyethylene glycol

[0037] Mix eight-armed polyethylene glycol (8sPEG, Mw=20k) with thiourea and ethyl 2-bromometha...

Embodiment 2

[0049] A preparation method of zwitterionic hyperbranched polyethylene glycol hydrogel with high antifouling performance, comprising the following steps:

[0050] (1) Synthesis of double bond-containing sulfobetaine zwitterionic monomer (SBMA)

[0051] Dissolve N-(N,N'-dimethylaminopropyl)acrylamide (DMAPAA, 2.0g, 12.8mmol) in 10mL of anhydrous acetone, and then add β-sultone monomer (1g, 14.02mmol ) was dissolved in 10mL of anhydrous acetone, and under the stirring condition of 600r / min, it was slowly added dropwise to the acetone solution of DMAPAA, and the reaction at room temperature was continued for 18h under the protection of nitrogen. Washed with acetone three times and dried in vacuum to obtain double bond-containing zwitterionic monomer SBMA, the chemical reaction formula of which is shown below.

[0052]

[0053] (2) Synthesis of functionalized modified multi-arm polyethylene glycol

[0054]Mix eight-armed polyethylene glycol (8sPEG, Mw=10k) with thiourea and e...

Embodiment 3

[0066] A preparation method of zwitterionic hyperbranched polyethylene glycol hydrogel with high antifouling performance, comprising the following steps:

[0067] (1) Synthesis of double bond-containing carboxybetaine zwitterionic monomer (CBMA)

[0068] N-(N,N'-dimethylaminopropyl)acrylamide (DMAPAA, 4.0g, 25.6mmol) was dissolved in 15mL of anhydrous acetone, and then β-propiolactone monomer (1.5g, 20.4mmol ) was dissolved in 15mL of anhydrous acetone, and under the stirring condition of 800r / min, it was slowly added dropwise to the acetone solution of DMAPAA, and the reaction at room temperature was continued for 20h under nitrogen protection. After the reaction was completed, the white precipitate was obtained by filtration, and used Washed with acetone three times and dried in vacuum to obtain double bond-containing zwitterionic monomer CBMA, its chemical reaction formula is shown below.

[0069]

[0070] (2) Synthesis of functionalized modified multi-arm polyethylene ...

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Abstract

The invention discloses zwitterionic hyperbranched polyether hydrogel with high anti-fouling performance as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) synthesizing a betaine zwitterionic monomer containing double bonds; (2) synthesizing functionally modified multi-arm polyethylene glycol; (3) synthesizing hyperbranched polyethylene glycol containing betaine zwitterions; and (4) constructing hyperbranched polyethylene glycol hydrogel containing the betaine zwitterions. A hydrogel carrier material prepared by the method has excellent anti-fouling performance, can efficiently prevent biomolecules, cells and the like from being in contact with gel, can achieve low-concentration rapid in-situ gel forming at the same time, thenshows excellent biocompatibility and stability, is similar to natural vitreous bodies in performance, and effectively meets the requirements for long-term stability and biocompatibility of the vitreous bodies for clinical operations.

Description

technical field [0001] The invention belongs to the technical field of hydrogel preparation, and in particular relates to a zwitterionic hyperbranched polyether hydrogel with high antifouling performance and a preparation method and application thereof. Background technique [0002] Vitrectomy for the treatment of various eye diseases usually requires the injection of filling materials to replace the excised vitreous body to support the vitreous cavity and maintain intraocular pressure, which plays an important role in the prognosis of the disease and the prevention of complications. The current clinical vitreous fillers, such as gas, inflation gas, perfluorocarbon liquid, silicone oil, etc., cannot achieve long-term filling, and the side effects affect the prognosis. Due to its excellent anti-fouling properties, zwitterionic hydrogels can prevent proteins, cells and other biomolecules in the eye from contacting the gel, thereby avoiding a series of complications including i...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/52A61L27/50C08J3/075C08L87/00C08G81/00C08G65/334C08G65/333
CPCA61L27/18A61L27/50A61L27/52A61L2430/16C08G65/33396C08G65/3348C08G81/00C08J3/075C08J2387/00C08J2487/00C08L71/02
Inventor 曹俊张明施文强郭波刘竞择朱雨桐蔡胜胜何斌
Owner SICHUAN UNIV
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