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Application of polyethylene glycol hydrogel in preparation of self-adhesive biomedical material

A biomedical material, polyethylene glycol technology, applied in the application field of polyethylene glycol hydrogel in the preparation of self-adhesive biomedical materials, can solve the problems of toxic and side effects, inconvenient use, etc., and achieve high safety , easy to use and convenient effects

Active Publication Date: 2022-07-29
SHANGHAI RUINING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The film material can be rolled into a hollow tubular structure at the target tissue position to achieve the purpose of wrapping the tissue. However, this method needs to add additional adhesives to maintain the tubular structure, which brings inconvenience to use. The introduction of adhesives is also possible cause toxic side effects

Method used

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  • Application of polyethylene glycol hydrogel in preparation of self-adhesive biomedical material
  • Application of polyethylene glycol hydrogel in preparation of self-adhesive biomedical material
  • Application of polyethylene glycol hydrogel in preparation of self-adhesive biomedical material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of the self-adhesive polyethylene glycol hydrogel film of the present invention

[0033] Dissolve 400 mg of ester-bonded benzaldehyde group-terminated 8-arm polyethylene glycol (molecular weight 20 kDa) in 2 mL of 0.1 M phosphate buffer solution (pH 7.4) as solution A; A phosphate buffer solution with a base amino ratio of 1:1) was used as the B solution; a tetrafluoro ring (inner diameter 1.5cm) and a glass slide were used to make a mold, and the A and B solutions were mixed in equal volumes and then placed in a centrifuge tube using a vortex. Mix well with a rotary shaker, quickly pipette 125 μl of the mixture dropwise to the center of the Teflon circle, and make the droplet spread on the surface of the glass slide. After waiting for 10 minutes, the cured gel is removed to form a hydrogel film (such as figure 1 shown).

Embodiment 2

[0034] Example 2 Adhesion test between self-adhesive polyethylene glycol hydrogel films of the present invention

[0035] Dissolve 400 mg of ester-linked benzaldehyde group-terminated 8-arm polyethylene glycol (molecular weight 20 kDa) in 2 mL of 0.1 M phosphate buffer solution (pH 7.4) as solution A; The phosphate buffer solution with amino molar ratio of 2:1, 1:1, 1:1.5 and 1:2) was used as the B solution; the mold was made by using a tetrafluoro mold (2cm×1cm) and a glass slide, and the A After mixing equal volumes of solution B and solution B, mix thoroughly with a vortex shaker in a centrifuge tube, and quickly pipette 125 μl of the mixture dropwise into the center of the Teflon circle, so that the droplets are spread on the surface of the glass slide. After waiting for 10 minutes, the cured gel is removed to form a hydrogel film. Two pieces of hydrogel film (2cm×1cm) were figure 2 Mode stacking (overlapping area 1cm×1cm) Place a 200g weight on the stacking site for 5 ...

Embodiment 3

[0039] Example 3 Adhesion test of polyethylene glycol hydrogel films based on different polyamino polymers

[0040] Dissolve 400 mg of ester-linked benzaldehyde group-terminated 8-arm polyethylene glycol (molecular weight 20 kDa) in 2 mL of 0.1 M phosphate buffer solution (pH 7.4) as solution A; configure polylysine or polyethylene The phosphate buffer solution of imine solution (the molar ratio of aldehyde groups to amino groups is 2:1, 1:1) is used as solution B; the mold is made by using a tetrafluoro mold (2cm×1cm) and a glass slide, and solutions A and B are After equal volume mixing, fully mix with a vortex shaker in a centrifuge tube, and quickly pipette 125 μl of the mixture dropwise to the center of the Teflon circle, so that the droplets are spread on the surface of the glass slide. After waiting for 10 minutes, the cured gel is removed to form a hydrogel film. Two pieces of hydrogel film (2cm×1cm) were figure 2 Mode stacking (overlapping area 1cm×1cm) Place a 200...

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Abstract

The invention provides an application of polyethylene glycol hydrogel in preparation of a self-adhesive biomedical material. The polyethylene glycol hydrogel is formed by crosslinking aldehyde-terminated star-shaped multi-arm polyethylene glycol and polylysine. Research finds that the polyethylene glycol hydrogel film can realize self-adhesion of the hydrogel film through reaction of residual aldehyde groups on the surface and amino groups and related non-covalent interaction, and the hydrogel film can be further processed into complex shapes such as a hollow tube and the like through the self-adhesion effect. The polyethylene glycol hydrogel can be freely formed in the operation process, the self-adhesive film can wrap or support tissue, and the polyethylene glycol hydrogel has important application potential in the fields of tissue adhesion prevention, tissue engineering scaffolds and the like.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to the application of polyethylene glycol hydrogel in the preparation of self-adhesive biomedical materials. Background technique [0002] A hydrogel is a soft material containing a large amount of water obtained by cross-linking of hydrophilic polymers. Hydrogels have excellent physicochemical properties and biological properties, such as high water content, high elasticity, softness, and biocompatibility, and have important applications in biomedical research fields such as drug delivery and tissue engineering. [0003] Common uses of hydrogels are injectable hydrogels and preformed hydrogel blocks or films. The shape of the injectable hydrogel depends on the shape of the tissue at the injection site and cannot be precisely shaped. Once the pre-formed bulk gel is prepared, its shape cannot be changed. These two forms of hydrogels are limited in their applications. Compared ...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/52A61L27/50A61L31/06A61L31/14C08J3/075C08J3/24C08J5/18C08L71/02C08L77/04
CPCA61L27/26A61L27/52A61L27/50A61L31/041A61L31/145A61L31/14C08J3/075C08J3/246C08J5/18C08J2371/02C08J2477/04C08J2377/04C08J2471/02A61L2430/32C08L71/02C08L77/04
Inventor 闫振坤陈亮潘震
Owner SHANGHAI RUINING BIOTECH CO LTD
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