A kind of chitosan/polyethylene glycol hydrogel and its preparation method and application

A polyethylene glycol, four-arm polyethylene glycol technology, applied in bandages, medical science and other directions, can solve the problems of limited application of hydrogel materials, poor mechanical properties of hydrogels, etc., to promote wound healing, excellent antibacterial properties, etc. The effect of excellent performance and mechanical strength

Active Publication Date: 2022-05-24
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The inventors found that most of the hydrogels prepared in the prior art have poor mechanical properties, which limits the application of hydrogel materials in medicine, especially stomatology

Method used

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  • A kind of chitosan/polyethylene glycol hydrogel and its preparation method and application
  • A kind of chitosan/polyethylene glycol hydrogel and its preparation method and application
  • A kind of chitosan/polyethylene glycol hydrogel and its preparation method and application

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specific Embodiment approach

[0034] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0035] It should be noted that the terminology used herein is for the purpose of describing specific embodiments only, and is not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural as well, furthermore, it is to be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates that There are features, steps, operations, devices, components and / or combinations thereof.

[0036] In one embodiment of the present invention, a chitosan / polyethylene glycol hydrogel is pro...

Embodiment 1

[0071] Preparation of chitosan / polyethylene glycol hydrogel: Dissolve 0.1 g of chitosan in 10 mL of acetic acid solution with a concentration of 1% (v / v), heat it to 60 °C in a water bath, and stir at 200 rpm for 1 h. Use a 1000-mesh nylon microporous membrane to filter to obtain a pure chitosan solution, add 1M NaOH solution to adjust the pH to make the solution pH=6; transfer 1 mL of the chitosan composite solution to a centrifuge tube, add 10 mg of four-arm Polyethylene glycol active ester is used as a cross-linking agent, and the reaction mechanism is as follows figure 1 As shown in the figure, after sonicating for 10 min, let it stand for 1 h, slowly add 1 mL of 5% (w / v) NaOH solution, let it stand for 1 h to form an antibacterial hydrogel, and finally dialyze it with ultrapure water for 24 h until it becomes neutral.

Embodiment 2

[0073] Preparation of chitosan / polyethylene glycol antibacterial hydrogel: Dissolve 0.1 g of chitosan in 10 mL of acetic acid solution with a concentration of 1% (v / v), heat it to 60 °C in a water bath, and stir at 200 rpm for 1 h , using a 1000-mesh nylon microporous membrane to filter to obtain a pure chitosan solution, and adding a 1M NaOH solution to adjust the pH to make the solution pH=6. Add polyhexamethyleneguanidine hydrochloride with a concentration of 0.5% (w / v) and stir evenly with a magnetic sub, transfer 1 mL of chitosan composite solution to a centrifuge tube, add 10 mg of four-arm polyethylene glycol active ester As a cross-linking agent, after sonicating for 10 min, let it stand for 1 h, slowly add 1 mL of 5% (w / v) NaOH solution, let it stand for 1 h to form an antibacterial hydrogel, and finally dialyze it with ultrapure water for 24 h until it becomes neutral.

[0074] figure 2 and image 3 The actual renderings and SEM images of the chitosan / polyethylene...

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Abstract

The invention relates to the technical field of biomedicine, in particular to a chitosan / polyethylene glycol hydrogel and a preparation method and application thereof. The hydrogel is obtained by reacting the four-arm polyethylene glycol active ester with the primary amine in the chitosan molecule to generate an amide bond; the structure of the four-arm polyethylene glycol active ester is as follows: the structure of the chitosan molecule is as follows: prepared The hydrogel has a three-dimensional network porous structure, and has good water absorption and swelling properties in an acidic environment (the pH of the wound is slightly acidic), so that the prepared hydrogel has the application potential of promoting drug release and wound healing. Chitosan and four-armed polyethylene glycol active ester are chemically cross-linked to form amide bonds, which makes the prepared hydrogel have excellent mechanical strength, with a compressive strength of 440kPa, which can be used as an ideal material for tooth extraction site preservation technology. By loading polyhexamethyleneguanidine hydrochloride in the hydrogel material, the antibacterial performance of the hydrogel is enhanced, and the hydrogel can be applied to the field of tooth extraction socket wound dressing.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a chitosan / polyethylene glycol hydrogel and a preparation method and application thereof. Background technique [0002] The disclosure of information in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] In dentistry, dental implants are a more advanced method of repairing missing teeth. However, in the process of tooth extraction wound healing, bacterial infection will cause the wound to become inflamed and purulent, which is a difficult problem faced by the biomedical field. At the same time, due to the resorption of alveolar bone after tooth extraction, it is difficult to implant implants during dental implantation. There are fe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L5/08C08L71/02C08L79/00
CPCA61L26/008A61L26/0085A61L26/0052A61L26/0066C08J3/075C08J3/246A61L2300/232A61L2300/216A61L2300/404A61L2300/45A61L2300/602C08J2305/08C08J2471/02C08J2479/00C08L5/08C08L71/02C08L79/00
Inventor 蒋妍彦韩宜君陈帆王凤龙李辉
Owner SHANDONG UNIV
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