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Preparation method and application of hydrogel based on poly-N-PPG-PEG (poly-N-phenylglycine-polyethylene glycol)

A technology of phenylglycine and polyethylene glycol is used in medical preparations containing active ingredients, pharmaceutical formulations, non-active ingredients of polymer compounds, etc., to achieve cheap raw materials, good photothermal conversion efficiency and photothermal stability, Simple to use effects

Active Publication Date: 2018-05-18
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The laser of the polyaniline polymer photothermal reagent prepared above is the laser of the first window of near-infrared, and there is no report about the laser treatment of the second window of near-infrared prepared into a photothermal gel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] The preparation method based on poly-N-phenylglycine-polyethylene glycol hydrogel comprises the following steps:

[0025] (1) Preparation of poly-N-phenylglycine-polyethylene glycol nanocomposite (PPG-PEG)

[0026] Weigh 1.06 g (7 mmol) of N-phenylglycine (PG) and dissolve it in a round bottom flask containing 50 mL of sulfuric acid aqueous solution (0.1 M), add magnetic stirring, and stir in an ice-water bath for 10 min;

[0027] Then weigh 16 g of polyethylene glycol (PEG) and add it to the round-bottomed flask of the acidic aqueous solution of the PG monomer, and continue stirring for 30 minutes to obtain the PG-PEG acidic aqueous solution;

[0028] Then weigh 1.60 g (7 mmol) of ammonium persulfate (APS) and dissolve it in 50 ml of sulfuric acid solution (0.1 M), then slowly add the APS acidic solution to the prepared PG-PEG acidic aqueous solution, drop about 3 h, kept in ice bath for 5 h, then raised to room temperature and stirred for 24 h to obtain a dark green ...

experiment example

[0032] In Example 1, the PPG-PEG complex described in step (1) was prepared to be 30 mg / mL, and a 1064 nm laser (0.5W / cm 2) after 5 min of irradiation, turn off the laser light source, and let it cool down to room temperature naturally. During the whole process, the MAG30 infrared thermal imager was used to record the temperature change and calculate the light-to-heat conversion efficiency.

[0033] The poly-N-phenylglycine smart hydrogel obtained in the step (2) of Example 1 was irradiated with a 1064 nm laser (0.5W / cm 2 ) irradiated, and the temperature of the gel was recorded as a function of the light time with an infrared thermal imager.

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Abstract

The invention discloses a preparation method and application of hydrogel based on poly-N-PPG-PEG, the preparation method comprises the steps that firstly, a poly-N-PPG-PEG nano-composite is prepared,then PPG-PEG nano-composite powder and cyclodextrin (alpha-CD) are prepared into aqueous solutions with certain concentrations respectively, the aqueous solutions are mixed uniformly and stood at theroom temperature for a period of time, and the poly-N-PPG-PEG is prepared. The ultraviolet absorption peak of the prepared hydrogel is shifted to a near-infrared second window, the laser penetration depth can be increased through laser radiation of the near-infrared second window, the absorption of laser by a living tissue is reduced, and damage to the normal tissue is reduced. The hydrogel is injectable type intelligent hydrogel with temperature and shear sensitivity double response, can load chemotherapy drugs so that the drugs can be released at fixed points as required, and belongs to thephoto-thermal hydrogel carrying system for enhancing chemotherapy and photo-thermal combined treatment.

Description

technical field [0001] The invention relates to a photothermal therapy reagent, which belongs to the technical field of biomedical materials, in particular to a preparation method based on poly-N-phenylglycine-polyethylene glycol hydrogel and its application in the second near-infrared window. Background technique [0002] Photothermal therapy is a therapy in which photothermal materials absorb near-infrared light under laser irradiation, convert light energy into heat energy, and generate high heat in tumor tissue to kill diseased cells. It has the characteristics of precision, high efficiency, controllability, non-invasiveness, and low side effects. In recent years, near-infrared lasers have been widely used in hyperthermia due to their strong penetrating ability to living tissues. Among them, the absorption of most nanoparticles is in the first near-infrared window (750 nm~900 nm). In contrast, the second near-infrared window laser absorbs and scatters less to blood and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L77/00C08L5/16C08G69/40A61K41/00A61K9/06A61K47/40A61P35/00C08B37/00
CPCA61K9/06A61K41/0052A61K47/40C08B37/0015C08G69/40C08J3/075C08J2305/16C08J2377/00C08J2405/16C08J2477/00
Inventor 沈星灿胡海露刘婵娟石睿卢钰
Owner GUANGXI NORMAL UNIV
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