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Novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel and preparation method thereof

A polyglycolide and polyethylene glycol technology, applied in the field of materials, can solve the problems of few reports and difficult to control hydrogel degradation performance, and achieve high reaction selectivity, good biocompatibility, and reaction conditions. mild effect

Active Publication Date: 2018-11-02
XINYANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of block copolymer has the potential for cell loading gels, but there are few reports. Mulyasasmita et al. prepared eight-armed polyethylene glycol-polypeptide copolymer gels, which are used for cell loading, but the hydrogel It is difficult to control the degradation performance of [J.Control.Release,2014,191,71]

Method used

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  • Novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel and preparation method thereof
  • Novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel and preparation method thereof
  • Novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel and preparation method thereof

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Embodiment 1

[0030] A novel polyethylene lactide-polyethylene glycol hydrogel, said hydrogel is composed of four-arm polyethylene lactide-polyethylene glycol-azide copolymer and four-arm alkynyl through azide -Click chemistry reaction between alkyne groups.

[0031] The structural formula of the four-arm polyethylene lactide-polyethylene glycol-azide copolymer is:

[0032]

[0033] The structural formula of the four-arm alkynyl small molecule is:

[0034]

[0035] Its specific reaction formula is:

[0036]

[0037] The preparation method of the novel polyethylene lactide-polyethylene glycol hydrogel is prepared by the following steps: 1) mixing four-arm polyethylene lactide-polyethylene glycol-azide copolymer with water to obtain Four-arm polyethylene lactide-polyethylene glycol-azide copolymer aqueous solution; four-arm alkynyl is mixed with water to obtain a four-arm alkynyl aqueous solution; the four-arm polyethylene lactide-polyethylene glycol-azide The concentration of cop...

Embodiment 2

[0056] In the present embodiment, the synthesis process of the four-arm polylactide-polyethylene glycol-azide copolymer is:

[0057] i) Synthesis of linear polyethylene lactide-polyethylene glycol-azide copolymer: add 0.008mol monomethyl ether polyethylene glycol (M w =500~1200), heat to melt, then add lactide and glycolide, heat to melt completely under the protection of dry nitrogen, add 0.01g stannous octoate, raise the temperature to 140°C, react for 10h, add di Chloromethane and glacial ether were purified to obtain intermediate product 1 (dissolve the product with dichloromethane first, then add glacial ether, the amount of glacial ether added is more than 10 times the volume of dichloromethane, take the precipitate, and vacuum Drying, it is the intermediate product 1); the obtained intermediate product 1 is dissolved in dichloromethane, and the dissolution is completed, stirred under the protection of nitrogen, adding 0.001mol triethylamine, adding methanesulfonyl chlor...

Embodiment 3

[0063] In the present embodiment, the synthesis process of the four-arm polylactide-polyethylene glycol-azide copolymer is:

[0064] i) Synthesis of linear polyethylene lactide-polyethylene glycol-azide copolymer: add 0.008mol monomethyl ether polyethylene glycol (M w =500~1200), heat to melt, add lactide and glycolide, heat to melt completely under the protection of dry nitrogen, add 0.01g stannous octoate, raise the temperature to 160°C, react for 6 hours, add di Chloromethane and glacial ether were purified to obtain intermediate product 1 (the product was first dissolved with dichloromethane, and then glacial ether was added. The amount of glacial ether added was more than 10 times the volume of dichloromethane, and the precipitate was taken under vacuum at 60 ° C. Drying, it is the intermediate product 1); the obtained intermediate product 1 is dissolved in dichloromethane, and the dissolution is completed, stirred under the protection of nitrogen, adding 0.001mol of trie...

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Abstract

The invention provides novel poly(D,L-lactide-co-glycolide)-polyethylene glycol hydrogel. The hydrogel is a product prepared by carrying out click chemical reaction of azido-alkynyl on a four-arm poly(D,L-lactide-co-glycolide)-polyethylene glycol-azido co-polymer and four-arm alkynyl; the hydrogel prepared by the method can be used for controlling gelling time through changing the concentration ofraw materials; the hydrogel has good biocompatibility and is a relatively ideal medical controlled release material and a cell loading material. The azido-alkynyl click chemical reaction is utilized,the selectivity of the reaction is high, reaction conditions are moderate and the reaction temperature is relatively wide; meanwhile, the hydrogel produced by the method has good stability in a shortperiod and can be degraded through a hydrolysis manner after a long period.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a novel polylactide-polyethylene glycol hydrogel and a preparation method thereof. Background technique [0002] Poly(ethylene lactide) is a synthetic polymer, which is used in the medical field because of its good biocompatibility and degradability. Polyethylene glycol can form temperature-responsive copolymers with polyester polymers [Nature., 1997, 388.60], such as polyethylene lactide-polyethylene glycol-polyethylene lactide [Chem .Soc.Rev.,2008,37], polyethylene glycol-polycaprolactone block copolymer [Macromolecules.,2006,39,4873], monomethyl ether polyethylene glycol-polycaprolactone block copolymer [Tissue Eng., 2006, 12, 2863] and so on. Suo Jinping, Huazhong University of Science and Technology synthesized a multi-arm polyethylene lactide-monomethyl ether polyethylene glycol block copolymer, and then configured it into an aqueous solution with a certain ...

Claims

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Application Information

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IPC IPC(8): C08G63/91C08G63/664C08J3/075C08L67/04A61K47/34
CPCA61K47/34C08G63/664C08G63/912C08J3/075C08J2367/04
Inventor 聂磊袁红雨董婧韩艳婷张春霞霍豪杰陈世峰
Owner XINYANG NORMAL UNIVERSITY
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