Chitosan/polyethylene glycol hydrogel and preparation method and use thereof

A polyethylene glycol, four-arm polyethylene glycol technology, applied in bandages, medical science and other directions, can solve the problems of limited application of hydrogel materials, poor mechanical properties of hydrogels, etc., to promote wound healing, excellent antibacterial properties, etc. Excellent properties and mechanical strength

Active Publication Date: 2021-12-17
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The inventors found that most of the hydrogels prepared in the prior art have poor mechanical properties, which limits the application of hydrogel materials in medicine, especially stomatology

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  • Chitosan/polyethylene glycol hydrogel and preparation method and use thereof
  • Chitosan/polyethylene glycol hydrogel and preparation method and use thereof
  • Chitosan/polyethylene glycol hydrogel and preparation method and use thereof

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specific Embodiment approach

[0034] It should be noted that the following detailed description is illustrative and is intended to provide a further description of the present application. Unless otherwise indicated, all technical and scientific terms used herein have the same meaning of ordinary skill in the relevant technical field application generally understood.

[0035] It should be noted that the terms used herein are intended to describe specific embodiments, and not intended to limit the exemplary embodiments of the present application. As used herein, unless the context further explicitly indicates that the singular form is intended to include multiple forms, but it should be understood that when the term "including" and / or "includes" in this specification, it indicates There is a combination of features, steps, operations, devices, components, and / or their combinations.

[0036] One embodiment of the present invention, there is provided a chitosan / polyethylene glycol hydrogels, obtained by the...

Embodiment 1

[0071] Preparation of chitosan / polyethylene glycol hydrogel: 0.1 g of chitosan is dissolved in a acetic acid solution having a 10 ml concentration of 1% (V / V), and the water bath is heated to 60 ° C, stirred at a rotational speed of 200 rpm. The pure chitosan solution was obtained using 1000 mesh nylon microporous filtration membranes, and a NaOH solution of 1 m was added to regulate the acid alkalinity, so that the solution pH = 6; transfer 1 ml of chitosan composite solution to the centrifuge tube, add 10 mg of four arms Polyethylene glycol active esters as crosslinking agents, reaction mechanisms such as figure 1 As shown, the ultrasonic was allowed to stand for 1 h after 10 min, and the NaOH solution of 1 ml of a concentration of 5% (w / v) was slowly added, and the hydrogens of the antibacterial hydrogel was formed for 1 h, and finally using ultrapure water dialysis 24 h.

Embodiment 2

[0073] Preparation of chitosan / polyethylene glycolic hydrogel: 0.1 g of chitosan is dissolved in a acetic acid solution of 10 ml of concentration of 1% (v / v), and the water bath is heated to 60 ° C, stirred at a rotational speed of 200 rpm. The pure chitosan solution was obtained by filtration using 1000 mesh nylon microporous filtration membranes, and a NaOH solution of 1 m was added to prevent the acid and alkalinity, so that the solution pH = 6. Add concentration of 0.5% (w / v) polyethylene guanidine hydrochloride and mix well using a magnetic stirred, 1 ml of chitosan composite solution to centrifugal tube, add 10 mg of four-arm polyethylene glycol active ester As the crosslinking agent, the ultrasonic is allowed to stand for 1 h after 10 min, and a NaOH solution of 1 ml of a concentration of 5% (w / v) is slowly added, and the antibacterial hydrogel is formed to form an antibacterial hydrogel, and finally use ultrapure water dialysis 24 h.

[0074] figure 2 and image 3 ...

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Abstract

The invention relates to the technical field of biological medicine, in particular to chitosan/polyethylene glycol hydrogel and a preparation method and use thereof. The hydrogel is obtained by reacting four-arm polyethylene glycol active ester with primary amine in chitosan molecules to generate amido bonds. A structure of the four-arm polyethylene glycol active ester is as follows: a structure of the chitosan molecule is as follows: the prepared hydrogel has a three-dimensional network porous structure and has a good water absorption swelling performance in an acid environment (pH at a wound is slightly acidic), and thus has potentials of promoting drug release and promoting wound healing. The chitosan and the four-arm polyethylene glycol active ester are chemically crosslinked to form the amido bonds, such that the prepared hydrogel has an excellent mechanical strength and a compression strength reaching 440 kPa, and can be used as an ideal material for a tooth extraction site preservation technology. Polyhexamethylene guanidine hydrochloride is loaded in the hydrogel material, such that an antimicrobial property of the hydrogel is enhanced, and the hydrogel can be used to the field of tooth extraction cavity wound dressings.

Description

Technical field [0001] The present invention relates to the field of biotechnology medicine, in particular to a chitosan / hydrogel and preparation method and use of polyethylene glycol. Background technique [0002] The information disclosed in the background is disclosed only to increase the understanding of the overall background of the present invention, and is not necessarily considered to admit or imply that the information is intended to be a prior art known to those skilled in the art. [0003] In dentistry, dental implants are more advanced restorative dental defects. But in the extraction wound healing process, the bacterial infection can cause inflammation of the wound fester, this is a problem faced by the biomedical field. Meanwhile, because the alveolar bone resorption after tooth extraction, dental implants cause difficulties when the implant, using less material scaffold alveolar ridge preservation, storage and use of hydrogel scaffold in the case of alveolar ridg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L5/08C08L71/02C08L79/00
CPCA61L26/008A61L26/0085A61L26/0052A61L26/0066C08J3/075C08J3/246A61L2300/232A61L2300/216A61L2300/404A61L2300/45A61L2300/602C08J2305/08C08J2471/02C08J2479/00C08L5/08C08L71/02C08L79/00
Inventor 蒋妍彦韩宜君陈帆王凤龙李辉
Owner SHANDONG UNIV
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