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Method of preparing polyethylene glycol and protein fiber combined artificial cardiac valve

An artificial heart valve, protein fiber technology, applied in heart valve, medical science, prosthesis, etc., to achieve the effect of satisfying durability, preventing calcification, and good biocompatibility

Active Publication Date: 2016-02-17
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing a polyethylene glycol-protein fiber composite artificial heart valve, aiming at problems such as life-long administration of anticoagulants and calcification and immune rejection of biological valves for artificial mechanical valves commonly used in clinical practice. Egg membrane protein fibers with excellent mechanical properties and polyethylene glycol with good biocompatibility are used as raw materials to prepare composite layered artificial heart valves, which can be controlled by adjusting the number of egg membrane layers, the volume and concentration of polyethylene glycol solution The thickness and strength of the composite layered artificial heart valve have important clinical application value

Method used

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  • Method of preparing polyethylene glycol and protein fiber combined artificial cardiac valve
  • Method of preparing polyethylene glycol and protein fiber combined artificial cardiac valve
  • Method of preparing polyethylene glycol and protein fiber combined artificial cardiac valve

Examples

Experimental program
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Embodiment 1

[0030] Raw materials and requirements: fresh egg membrane, polyethylene glycol, acryloyl chloride, triethanolamine (TEOA), eosin (EosinY), PBS solution, ethanol, N-vinylpyrrolidone (NVP), 40% sodium bisulfite solution, Ultrapure water (all chemical reagents are of analytical grade).

[0031] PEGDA synthesis: Polyethylene glycol diacrylate (PEGDA) is prepared by reacting polyethylene glycol (PEG) with acryloyl chloride;

[0032] Egg film treatment: remove the egg yolk and egg white in raw eggs, carefully peel off the egg film from the air cell of the egg, wash it with deionized water for 3 times, soak the egg film in acetic acid with a concentration of 8mol / L, and treat it at 4°C for 12 hours , washed three times with deionized water. Afterwards, a semicircular sample with a diameter of 12 mm was cut and soaked in a PEGDA white light pre-gelling solution with a concentration of 20% by mass for 30 minutes at room temperature;

[0033] PDMS template production: prepare a 0.6mm ...

Embodiment 2

[0038] In this example, a semicircular model with a size of 12 mm (diameter) × 0.6 mm (thickness) will be prepared in the PDMS template, and 6 layers of processed egg membranes will be selected to fill the PDMS template, and the rest are the same as in Example 1. The elastic modulus of the artificial heart valve is 3.43MPa and the elongation rate reaches 43% as measured by the static tensile test.

Embodiment 3

[0040] In this example, a semicircular model with a size of 12 mm (diameter) × 0.6 mm (thickness) will be prepared in the PDMS template, and 4 layers of processed egg membranes will be selected to fill the PDMS template, and the rest are the same as in Example 1. The elastic modulus of the artificial heart valve is 3.30MPa and the elongation rate reaches 35% as measured by the static tensile test.

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Abstract

The invention discloses a method of preparing a polyethylene glycol and protein fiber combined artificial cardiac valve and belongs to the field of biomedical materials. The method comprises: covering egg shell membrane protein fiber with photo-crosslinked polyethylene glycol hydrogel to obtain a composite material, and preparing the composite lamellar artificial cardiac valve through crosslinking by further using a molecular crosslinking agent (such as glutaraldehyde). The polyethylene glycol hydrogel is prepared by means of photo-crosslinking, ensuring the integrity of artificial valve materials, protecting the covered protein fiber from the in-vivo enzymatic decomposition and preventing calcification of the artificial valve. The artificial cardiac valve material prepared by the method simulates the lamellar structure of human aortic valves and has mechanical properties similar to those of the human aortic valves, with good biocompatibility guaranteed, and the need of a replacement receptor for high valve durability, good tissue compatibility and dispensing with a lifetime of anticoagulation can be met.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing a polyethylene glycol-protein fiber composite artificial heart valve. Background technique [0002] Heart valve disease is an important disease that endangers human health. The calcification and fibrosis of the heart valve lead to left ventricular outflow tract infarction and severe aortic valve stenosis. So far, no surgical operation or medicine can cure calcified valve disease and other diseases. The only The feasible method is valve replacement, and the artificial valves currently used in clinical practice include mechanical valves and biological valves. However, after mechanical valve replacement, it is necessary to take anticoagulant drugs for life, otherwise complications such as thrombosis will occur. Considering that the implantation of mechanical valves will cause adverse reactions in the body, biological valves were produced in the 1...

Claims

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Application Information

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IPC IPC(8): A61F2/24A61L27/52A61L27/50A61L27/40
Inventor 张兴白芸杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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