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Polypropylene mesh/electrospinning nanofiber membrane and its preparation method and application

A polypropylene mesh and nanofiber membrane technology, applied in the field of medical devices

Active Publication Date: 2017-06-20
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, in the field of open abdominal cavity, there is no repair material that can not only protect the exposed intestine, but also promote the proliferation of body tissue, and at the same time provide sufficient repair effect

Method used

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  • Polypropylene mesh/electrospinning nanofiber membrane and its preparation method and application
  • Polypropylene mesh/electrospinning nanofiber membrane and its preparation method and application
  • Polypropylene mesh/electrospinning nanofiber membrane and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Polypropylene mesh was purchased from Bard Company in the United States. That is, a non-absorbable material woven from polypropylene monofilament, including a rectangular mesh of about 6cm x 4cm.

[0052] 2. Preparation of chitosan-polyethylene glycol hydrogel:

[0053] 1) Polyethylene glycol PEG (molecular weight 3000, 4000g mol -1 ) was dissolved in dichloromethane at 20-28°C under a nitrogen atmosphere, and the final concentration of PEG in the solution was 10% (g / 100ml);

[0054] 2) 4-dimethylaminopyridine and triethylamine are dissolved in dichloromethane to obtain mixed solution A, so that the concentration of 4-dimethylaminopyridine and triethylamine in mixed solution A is 0.375mol / L, and then The mixed solution A was added to the PEG-containing methylene chloride solution prepared in the previous step and stirred for 15 minutes to obtain a mixed solution B, and the volume ratio of the mixed solution A to the PEG-containing methylene chloride solution was 1:...

Embodiment 2

[0067] 1. Animals and grouping: 20 male SD rats (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), weighing 230-270 g, were randomly divided into 2 groups. Experimental group: the polypropylene mesh / nanofiber membrane prepared in Example 1 was cut into a polypropylene mesh / electrospinning nanofiber membrane composite patch group (referred to as the polypropylene mesh composite nanofiber membrane group) obtained by suitable specifications, Control group: polypropylene mesh group.

[0068] 2. Operation method: Animals were fasted for 8 hours before operation, and 1% ketamine 10ml / kg was injected intraperitoneally. After successful anesthesia, establish a model of abdominal wall defect after cecal ligation and perforation (CLP) caused by abdominal infection combined with abdominal hypertension (IAH). The mesangial border wall was suspended on the right abdominal wall with 3-0 sutures at 1 cm above and below, and the abdomen was closed in two layer...

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Abstract

The invention relates to a polypropylene mesh sheet / electrospinning nanofiber membrane and a preparation method and application thereof. The polypropylene mesh / electrospun nanofibrous membrane was prepared by the following steps: 1) preparation of chitosan‐polyethylene glycol hydrogel; 2) preparation of polylactic acid‐glycolic acid copolymer embedded with basic fibroblast factor bFGF PLGA microspheres; 3) preparation of electrospinning solution; 4) preparation of polypropylene mesh / electrospinning nanofiber membrane by electrospinning. The invention creatively combines the polypropylene mesh with the nanofiber membrane, uses the nanofiber membrane to improve the biocompatibility of the polypropylene mesh, and uses the polypropylene mesh to improve the tensile strength of the nanofiber membrane, the two complement each other, and then The introduction of microspheres to achieve controlled release of drugs can fill in many deficiencies of the existing clinical polypropylene mesh.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a polypropylene mesh / electrospinning nanofiber membrane and a preparation method and application thereof. Background technique [0002] The experience and lessons of war wound treatment from the Second World War to the local wars in Afghanistan and Iraq show that the incidence of abdominal war wounds has not decreased significantly, and it has always been the third fatal war wound. Abdominal injury caused by blast injury can lead to different degrees of abdominal wall damage, exposure of abdominal viscera, and intestinal prolapse. Combining intra-abdominal hypertension after resuscitation from hemorrhagic shock and traumatic shock can lead to dehiscence of the abdominal incision, leading to passive opening of the abdominal cavity. Active abdominal opening is often required for the treatment of shock associated with abdominal compartment syndrome (ACS). Whether the abdominal cavity ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H13/00D01D1/02A61L31/04A61L31/14
Inventor 任建安陈国璞吴秀文王革非邓友铭黎介寿
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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