Polycaprolactone diacrylate/polyethylene glycol hydrogel stent and preparation method and application thereof

Abstract

The invention discloses a polycaprolactone diacrylate / polyethylene glycol hydrogel stent and a preparation method and application thereof. Polyethylene glycol serves as a hydrophilic block, and polycaprolactone diacrylate serves as a hydrophobic block; the mass ratio of the polyethylene glycol to the polycaprolactone diacrylate is (3-7):(3-7); the interior of polycaprolactone diacrylate / polyethylene glycol hydrogel is of a porous structure, and the pore size is 40-110 microns; the hydrogel stent is internally porous and has good elasticity, degradability and biocompatibility, the porous structure can be used for drug delivery and tissue engineering, and cells in cell embedding and growth can be uniformly inoculated into the stent without pretreatment. The polycaprolactone diacrylate / polyethylene glycol hydrogel stent has the advantages that due to the addition of the polycaprolactone diacrylate, the high crystallinity and hydrophobicity of the polyethylene glycol chain segment are improved, the viscosity of the hydrogel in the sol state is reduced, and the stent has good application prospects.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a polycaprolactone diacrylate / polyethylene glycol hydrogel scaffold and its preparation method and application. Background technique [0002] Polyethylene glycol is non-toxic, non-irritating, has good water solubility, and has good compatibility with various organic components, and has excellent moisturizing properties, dispersibility and biocompatibility, etc. It has a wide range of applications in food processing and other fields; polycaprolactone diol is a typical biodegradable thermoplastic material, which can be degraded into carbon dioxide and water in vivo, and has good biocompatibility. It is widely used in the field of biomedicine. [0003] The current gel materials are developing rapidly, but there are still the following problems: long response time, mechanical properties to be further improved, and poor biocompatibility and biodegradability; in addition, the curren...

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Problems solved by technology

[0003] The current gel materials are developing rapidly, but there are still the following problems: long response time, mechanical properties to be further improved, and poor biocompatibility and biodegradability; in addition, the current PEG-PCL block copolymer is the original When using a hydrogel material, due to the strong crystallinity and hydrophobicity of the PCL segment, it is not suitable for embedding cells. In addition, the hydrogel formed by this material has a high viscosity in the sol state and is inconvenient to inject, and the modulus is too large and the degradation rate is too slow, which seriously limits the application of current hydrogel materials.

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