Method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel

A biocompatibility and polyethylene glycol technology, applied in the field of enhancing the biocompatibility and degradability of polyethylene glycol hydrogel, can solve the problem that the biocompatibility of polyethylene glycol is not ideal and biological materials cannot It is degraded by organisms, and there are few researches on improvement methods, so as to achieve the effects of improving biocompatibility and degradability, promoting cell reproduction, and easy operation

Inactive Publication Date: 2017-03-08
武汉枫霖科技有限公司
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Problems solved by technology

However, there are still some problems in the current application of this biomaterial. First, the biocompatibility of polyethylene glycol to sensitive cells is not ideal. Secondly, polyethylene glycol biomaterials cannot be degraded by organisms. These shortcomings limit its further application. For a wide range of applications, and there is less research on the improvement of its shortcomings, there is still no good way to solve this problem

Method used

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  • Method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel
  • Method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel
  • Method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel

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Embodiment Construction

[0018] The implementation of the present invention will be illustrated by specific specific examples below, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0019] A method for enhancing the biocompatibility and degradability of polyethylene glycol hydrogel, comprising the steps of:

[0020] (1) Preparation of acylated polyethylene glycol: Under nitrogen conditions, take a certain amount of polyethylene glycol and methacryloyl chloride to react overnight. After the reaction is completed, purify the synthesized acylated polyethylene glycol. Alcohol was added with 0.2 ml of methacryloyl chloride to react, and the purification method was ether precipitation and overnight freeze-drying, and then tested by nuclear magnetic resonance, as shown in figure 1 As shown, its test purity is greater than 95%, and the degree of acylation is close to 100%;

[0021] (2) Preparation of ...

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Abstract

The invention discloses a method for enhancing biocompatibility and degradability of polyethylene glycol hydrogel. The method includes the steps of (1), preparing acylation polyethylene glycol; (2), preparing acylation polypeptide; (3), separating human mesenchymal stem cells; (4), performing induced differentiation on the mesenchymal stem cells to obtain chondrocytes. The method for enhancing the biocompatibility and degradability is advanced in technique, simple in steps, simple to operate, and capable of promoting the biocompatibility and degradability of a biomaterial stent and promoting cell reproduction and tissue regeneration.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for enhancing the biocompatibility and degradability of polyethylene glycol hydrogel. Background technique [0002] Polyethylene glycol has the advantages of safety, free modification, and excellent biophysical properties. It has been widely used in many medical fields, and is a biomaterial that has passed the US FDA safety certification and can be used externally or taken internally. Based on these excellent properties of polyethylene glycol, biomaterial scaffolds constructed by various cross-linking techniques can be widely used in the field of tissue engineering. However, there are still some problems in the current application of this biomaterial. First, the biocompatibility of polyethylene glycol to sensitive cells is not ideal. Secondly, polyethylene glycol biomaterials cannot be degraded by organisms. These shortcomings limit its further application. It is w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/077C08J3/075C08J3/24C08L71/02
CPCC08J3/075C08J3/246C08J2371/02C08L71/02C12N5/0655
Inventor 崔晓峰高桂芳
Owner 武汉枫霖科技有限公司
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