36 results about "Biomaterial scaffold" patented technology

It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.

The present invention refers to a process for preparing a biomaterial scaffold said method comprising, (a) providing a hydrogel comprising a fibrin network and a polysaccharide network; (b) subjecting the hydrogel of step a) to a freeze-thawing process to physically crosslink the hydrogel; and (c) subjecting the physically cross-linked hydrogel obtained after conducting the step b), to a lyophilization. The invention also relates to the biomaterial scaffold obtainable by the process as defined above, as well said biomaterial scaffold for its use to partially or completely increase, restore or replace the functional activity of a diseased or damaged oral mucosa.

A layered manufacturing method of a three-dimensional microfluidic porous scaffold comprises the following steps: simulating the microstructure of a real organ, manufacturing a resin die with a microfluidic structure copying a blood vessel system, copying a negative mode of the microfluidic structure with silicon rubber, filling the negative mode with solution of biological materials, moving the silicon rubber die upwards to enable the solution of biological materials to be contacted with an ultra-low temperature flat plate vertically, moving the silicon rubber die downwards to realize demolding of the frozen structure of the biological materials after solidification of solution of the biological materials, realizing precision interlayer orientation as well as freezing, condensation and forming of the three-dimensional microfluidic porous scaffold by repeatedly performing filling of the solution of biological materials and moving up and down of the silicon rubber die, obtaining the three-dimensional frozen structure of the biological materials, and vacuum freeze drying the ultra-low temperature flat plate and the three-dimensional frozen structure of the biological materials, and finally obtaining the scaffold of the biological materials with a three-dimensional microfluidic system and an oriented porous structure. The layered manufacturing method has the advantage of forming a three-dimensional organ scaffold with a complex space microfluidic system and the oriented porous structure directly.

The invention discloses a mandibular implant and a manufacturing method thereof, including the steps of designing and manufacturing the negative shape of the bracket, designing and making the outer shell, perfusing biological materials, heating to melt the negative shape of the bracket and the outer shell, sandblasting to remove wax, and dissolving with dilute hydrochloric acid. . The invention has the internal structure capable of imitating the natural bone of the human body, and manufactures a mandibular implant with a dense layer and a loose layer, which is similar to the internal structure and mechanical properties of the natural bone of the human body; during the process of filling the negative material of the bracket, the shell provides Give negative external stress to the scaffold, so that the negative structure of the scaffold is stable and not easy to collapse; by corroding the internal pores of the biomaterial scaffold, growth factors and bone cells are more likely to attach to the surface of the pores, and the amount of attachment is more, effectively improving the survival rate of bone Etc.