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Manufacture method of tissue engineering bracket with both internal microstructure and individualized appearance

A technique for tissue engineering scaffolds and manufacturing methods, applied in medical science, prostheses, etc., can solve problems such as difficult control of process parameters, and achieve the effect of controllable internal microstructure and wide material adaptability

Inactive Publication Date: 2012-07-04
ZHEJIANG UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, although rapid prototyping can directly form any complex structure, it is very suitable for the production of scaffolds, but limited by the forming principle (such as ultraviolet light curing, laser powder sintering, etc.), it can only be formed for certain specific biological materials, and the manufacturing The process parameters are not easy to control

Method used

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  • Manufacture method of tissue engineering bracket with both internal microstructure and individualized appearance
  • Manufacture method of tissue engineering bracket with both internal microstructure and individualized appearance
  • Manufacture method of tissue engineering bracket with both internal microstructure and individualized appearance

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with the accompanying drawings.

[0024] refer to Figure 1 ~ Figure 4 , a method for manufacturing a tissue engineering scaffold having a controllable internal microstructure and a personalized shape, the manufacturing method comprising the steps of:

[0025] 1) Negative design of the support structure

[0026] 1.1) Design the personalized shape of the stent: First, use the image-based 3D reconstruction technology to reconstruct the 3D model of the bone defect from CT data, and then obtain the repair model through the mirror algorithm or surface design method, and separate the repair model from the repair model. The shape of the defect site is the personalized shape model of the tissue engineering scaffold to be manufactured;

[0027] 1.2) Design porous microstructure: design a scaffold microstructure array with porosity and structural form, and the microstructure is an internal microstructure with ...

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Abstract

The invention relates to a manufacture method of a tissue engineering bracket with both an internal microstructure and an individualized appearance. The manufacture method comprises the following steps of: (1) designing the negative shape of a bracket structure; (2) printing the negative shape of the porous-structure bracket by a three-dimensional paraffin type printer; (3) uniformly mixing a biological material with self-solidifying property or hot coagulation property into slurry shape with a solution such as normal saline, pouring the slurry into holes of the negative shape of the porous-structure bracket, cooling and solidifying, and scraping off the redundant biological material from the surface of the bracket; and (4) heating the poured negative shape of the bracket into a heating furnace till the temperature of the negative shape is higher than the temperature of the melting point of the paraffin shape of the bracket, preserving the temperature for 1-5 minutes till paraffin is melted and disappears and the biological material is solidified to obtain the biological material bracket, and washing the biological material bracket with normal saline so as to obtain the tissue engineering bracket with both the internal microstructure and the individualized appearance. The manufacture method has wider adaptability to biological materials and internal microstructure controllability and can be used for manufacturing the tissue engineering bracket with the internal microstructure and the individualized appearance.

Description

technical field [0001] The invention relates to a manufacturing method of a tissue engineering bracket. Background technique [0002] Tissue engineering is the application of engineering and life science principles and methods to develop artificial biomaterials in order to restore, maintain or improve the function of defective tissues. As a science and technology for generating functional tissues and organs for transplantation, tissue engineering integrates image measurement technologies such as CT / MRI, 3D reconstruction technology, rapid prototyping technology, material engineering technology, bioengineering technology and other disciplines. The basic principle is that with the support of growth factors and nutrient solution, seed cells grow and expand in a scaffold made of special materials, and finally form a three-dimensional tissue guided by the scaffold. The three-dimensional tissue is transplanted into the patient's body to complete the reconstruction of the defectiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61L27/12
Inventor 刘云峰周根廖文清
Owner ZHEJIANG UNIV OF TECH
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