Mechanical property enhanced acellular spinal cord biomaterial scaffold and preparation method and application thereof

Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a mechanical property enhanced acellular spinal cord biomaterial scaffold and a preparation method and application thereof. In order to overcome the problem that an existing acellular spinal cord scaffold is insufficient in mechanical property, a polylactic acid-glycolic acid copolymer (PLGA) shell is spun outside an acellular spinal cord (DSC) through an electrospinning technology, and the mechanical property enhanced acellular spinal cord biomaterial scaffold is constructed. Compared with a simple DSC scaffold, the biomaterial scaffold has the enhanced mechanical property and better anti-pressure ability, and collapse of transplanted materials and compression of the transplanted materials by surrounding tissue can be prevented; and research shows that when the biomaterial scaffold is transplanted to a rat total transection spinal cord injury area, spinal cord injury can be effectively repaired, the problem that the mechanical property of the acellular spinal cord is poor is solved, and in-situ repair of spinal cord injury is further promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a mechanical property-enhanced acellular spinal cord biomaterial scaffold and a preparation method and application thereof. Background technique [0002] Spinal cord injury (SCI) is a central nervous system injury disease. With the development of economy and the aggravation of social aging, the incidence rate is further increased. According to statistics, the annual incidence of spinal cord injury worldwide is 23 / million, and the incidence in Asian countries, especially China and South Korea, is 12.06-61.6 / million. At present, there are about 2 million paraplegic patients caused by spinal cord injury in my country, and the number is increasing at a rate of about 50,000 every year, and it shows a trend of high morbidity, high disability rate, and younger age, which has brought huge consequences to the family and society. economic pressure. In China alone,...

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Problems solved by technology

[0004] In order to overcome the deficiencies of the above-mentioned prior art, the present invention provides a mechanically enhanced decellularized spinal cord biomaterial scaffold, which includes an internal decellularized spinal cord (DSC) and polylactic acid-polyglycolic acid surrounding the decellularized spinal cord The copolymer (poly D, L-lactic-co-glycolic acid, PLGA) shell is prepared by spraying PLGA electrospinning on the periphery of the DSC to form a thin shell. Compared with the simple DSC scaffold, its mechanical properties are improved by about 10 times , solve the problem of poor mechanical properties of the decellularized spinal cord, and can effectively promote the in situ repair of spinal cord injuries

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