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Method for increasing ceramic analog biological rack mechanical strength

A biological scaffold and mechanical strength technology, applied in the field of surface modification technology to enhance ceramic porous scaffolds, can solve the problems that are difficult to meet the needs of clinical and tissue engineering bone research and application, difficult to achieve safety, difficult to remove pathogens, etc. Achieve the effect of solving the needs of research and application and enhancing mechanical strength

Inactive Publication Date: 2006-05-03
丁建明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these natural materials are derived from animal bone tissue. After conventional treatment, it is difficult to remove all pathogens such as epiphyllum virus. It is very risky in clinical application and it is difficult to achieve 100% safety.
[0003] In order to solve this problem, the ceramic bone prepared by CN03134455.0 can completely remove the protein components in the bone, but the mechanical properties and toughness of the finished product have dropped a lot, especially cancellous bone, which can only be used as a filling material for small bone defects
It is difficult to meet the needs of clinical and tissue engineering bone research and application
At present, there are no natural bone and its derivatives products that can meet clinical needs in all aspects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0014] Select animal limb bone backbone, metaphysis, ribs, iliac crest and other irregular bones and cut them into desired shapes, rinse them with high-pressure water; put them in 0.5mol / L sodium hydroxide solution to degrease for 12 hours, rinse them thoroughly , washed with SDS for 2 hours, then rinsed, dried, and then dried in an oven at 60°C. The dehydrated and dried bones were calcined in a high-temperature furnace at 800°C for 2 hours, and cooled for later use.

[0015] After the above steps are completed, soak the ceramic bioscaffold in 3% gelatin. The process parameters during immersion are: the time is 1 hour, and the negative pressure is 40Kpa. Then, take it out and dry it in a drying oven at 70°C for 1 hour; then use 30mM EDC for cross-linking reaction, and then wash it with distilled water; finally dry it and dry it in an oven at 40°C to obtain the final product.

example 2

[0017] Select animal limb bone backbone, metaphysis, ribs, iliac crest and other irregular bones and cut them into desired shapes, rinse them with high-pressure water; put them in 0.5mol / L sodium hydroxide solution to degrease for 12 hours, rinse them thoroughly , washed with SDS for 2 hours, then rinsed, dried, and then dried in an oven at 60°C. The dehydrated and dried bones were calcined in a high-temperature furnace at 800°C for 2 hours, and cooled for later use.

[0018] After the above steps are completed, the ceramic bioscaffold is soaked in a chitosan solution with a concentration of 3%. The process parameters during soaking are: the time is 1.5 hours, and the negative pressure is 50Kpa. Then, take it out and dry it in a drying oven at 55°C for 2 hours; then use 30mM EDC for cross-linking reaction, and then wash it with distilled water; finally dry it and dry it in an oven at 40°C to obtain the final product.

example 3

[0020] (1) Mix TCP powder and PEG (pore forming agent) with a weight ratio of 1:1 evenly, and then mix the two evenly with silica sol to obtain a slurry for later use; (2) use distilled water with organic sponge , 75% ethanol, 95% ethanol cleaning, drying, subsequent use; (3) then the organic sponge after the above-mentioned treatment utilizes the dipping method to pour the slurry into the organic sponge, and remove excess slurry; (4) will get Place the organic sponge slurry complex in a drying oven at 50°C for 4 hours, then lower it to room temperature, and take it out for later use; place the organic sponge slurry complex obtained by the above steps in a high-temperature resistance furnace for calcination, and calcinate at 800°C After returning to room temperature for 3 hours, repeat steps (3) and (4), and then calcinate in a high-temperature resistance furnace at 1100° C. for 3 hours to obtain porous β-TCP.

[0021] After the above steps are completed, the ceramic bioscaffo...

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Abstract

The invention relates to reinforce mechanical strength of biomaterial frame with surface finish method, which comprises: (1) dipping the frame into gelatine solution or chitose solution or their mixed solution; (2) taking out to dry in drying cabinet for 1-2h at 50~80Deg; (3) using EDC or glutaral solution for crosslinking reaction; (4) cleaning; (5) drying in baking oven at 40Deg to obtain the product. Compared with prior art, this invention increases the frame strength 6~12 times to 4-6MPa and fits to application in clinic and research.

Description

[technical field] [0001] The invention relates to a method for enhancing the mechanical strength of a biological material support, in particular to a method for enhancing a ceramic porous support by using surface modification technology. [Background technique] [0002] In the prior art, repair materials for bone defects and scaffold materials for tissue engineered bone can be classified into artificial synthetic materials, natural materials and their derivatives, and their composites. Among the artificially synthesized inorganic materials, bioceramics have attracted much attention due to their good biocompatibility, especially β-TCP, due to their biodegradability; The tissue is similar, meets its own physiological requirements, and has good compatibility, especially its porous network structure, which is difficult to simulate artificially, and has potential commercial value. Such as patents: CN97108538.2, CN03117954.1, CN00132082.3 etc. disclosed are exactly the making and ...

Claims

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Application Information

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IPC IPC(8): C04B41/81C04B35/447C04B41/83
Inventor 丁建明蔡子升
Owner 丁建明
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