Method for increasing ceramic analog biological rack mechanical strength
A biological scaffold and mechanical strength technology, applied in the field of surface modification technology to enhance ceramic porous scaffolds, can solve the problems that are difficult to meet the needs of clinical and tissue engineering bone research and application, difficult to achieve safety, difficult to remove pathogens, etc. Achieve the effect of solving the needs of research and application and enhancing mechanical strength
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example 1
[0014] Select animal limb bone backbone, metaphysis, ribs, iliac crest and other irregular bones and cut them into desired shapes, rinse them with high-pressure water; put them in 0.5mol / L sodium hydroxide solution to degrease for 12 hours, rinse them thoroughly , washed with SDS for 2 hours, then rinsed, dried, and then dried in an oven at 60°C. The dehydrated and dried bones were calcined in a high-temperature furnace at 800°C for 2 hours, and cooled for later use.
[0015] After the above steps are completed, soak the ceramic bioscaffold in 3% gelatin. The process parameters during immersion are: the time is 1 hour, and the negative pressure is 40Kpa. Then, take it out and dry it in a drying oven at 70°C for 1 hour; then use 30mM EDC for cross-linking reaction, and then wash it with distilled water; finally dry it and dry it in an oven at 40°C to obtain the final product.
example 2
[0017] Select animal limb bone backbone, metaphysis, ribs, iliac crest and other irregular bones and cut them into desired shapes, rinse them with high-pressure water; put them in 0.5mol / L sodium hydroxide solution to degrease for 12 hours, rinse them thoroughly , washed with SDS for 2 hours, then rinsed, dried, and then dried in an oven at 60°C. The dehydrated and dried bones were calcined in a high-temperature furnace at 800°C for 2 hours, and cooled for later use.
[0018] After the above steps are completed, the ceramic bioscaffold is soaked in a chitosan solution with a concentration of 3%. The process parameters during soaking are: the time is 1.5 hours, and the negative pressure is 50Kpa. Then, take it out and dry it in a drying oven at 55°C for 2 hours; then use 30mM EDC for cross-linking reaction, and then wash it with distilled water; finally dry it and dry it in an oven at 40°C to obtain the final product.
example 3
[0020] (1) Mix TCP powder and PEG (pore forming agent) with a weight ratio of 1:1 evenly, and then mix the two evenly with silica sol to obtain a slurry for later use; (2) use distilled water with organic sponge , 75% ethanol, 95% ethanol cleaning, drying, subsequent use; (3) then the organic sponge after the above-mentioned treatment utilizes the dipping method to pour the slurry into the organic sponge, and remove excess slurry; (4) will get Place the organic sponge slurry complex in a drying oven at 50°C for 4 hours, then lower it to room temperature, and take it out for later use; place the organic sponge slurry complex obtained by the above steps in a high-temperature resistance furnace for calcination, and calcinate at 800°C After returning to room temperature for 3 hours, repeat steps (3) and (4), and then calcinate in a high-temperature resistance furnace at 1100° C. for 3 hours to obtain porous β-TCP.
[0021] After the above steps are completed, the ceramic bioscaffo...
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