Biomaterial scaffolds for controlled tissue growth

A biomaterial and tissue growth technology, applied in the field of implants and tissue scaffolds, can solve problems such as uncontrolled and unsuitable for tissue engineering scaffolds, and achieve the effect of optimizing the dissolution rate

Inactive Publication Date: 2010-09-01
UCL BUSINESS PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect that this invention allows for better control over how fast or slow fibers break down when exposed to water during manufacturing processes such as papermaking process.

Problems solved by technology

The technical problem addressed by this patented method relates to improving the efficiency with which certain chemicals like gases and other substances enter living organisms during their use in biomedical applications that require controlled delivery of these materials through specific areas on the surface of the material's interior.

Method used

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  • Biomaterial scaffolds for controlled tissue growth
  • Biomaterial scaffolds for controlled tissue growth
  • Biomaterial scaffolds for controlled tissue growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0102] experiment

[0103] method

[0104] Conical Fiber Preparation

[0105] The composition ratio is 0.5(P 2 o 5 ):0.25(CaO):(Na 2 O) dissolvable glass fibers with an average diameter of 30-40 μm (dissolving time in distilled water 8-10 hrs; spacing of 170 μm, cut into 2.3×3.5 cm and placed on a cover glass, fixed with autoclave tape. Then the cover glass Put into small Coplin container, then this container fills the Tris buffer solution (pH7.4) of 7ml 1%TRITON x-100 (Sigma). Remove liquid with the rate of 800 μ l per hour from this vial. Remove by the dehydration of ascending alcohol The accumulated hydrogel (for 20, 30, 40, 50, 60 and 90%, 5 minutes × 2; for 96%, 10 minutes × 2; for 100%, 15 minutes × 2) was washed with HMDS ( Hexamethyldisilazide) washing ends.

[0106] electron microscopy

[0107] The slides were left to dry overnight before the glass fibers were gently removed from the coverslips and mounted on sputter-coated stubs using standard procedures. ...

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Abstract

This invention relates to biomaterials for directional tissue growth which comprise soluble fibres having a variable cross-sectional area which dissolve in a directional manner in situ, thereby controlling the direction and rate of formation of microchannels within the biomaterial and allowing vectored and timed channelling through the biomaterial. This may be useful, for example in directing the growth of blood vessels, nerves and other repair cells through the biomaterial in defined directions.

Description

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Claims

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Application Information

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Owner UCL BUSINESS PLC
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