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Nanometer gamma-Fe2O3 relaxation rate standard substance and preparation method thereof

A standard substance, -fe2o3 technology, applied in the direction of drug delivery, emulsion delivery, iron oxide, etc., can solve the problems that have not been seen, and achieve the effect of simple operation, few steps and low cost

Active Publication Date: 2011-03-30
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, iron oxide magnetic liquid has entered the stage of clinical application as an MRI contrast agent. Foreign countries, including Advanced Magnetics of the United States and Schering of Germany, have developed more than a dozen products and some of them have been approved for marketing. There are already relevant product standards, but there is no corresponding one. Reports on the development of reference materials or standard samples, and there is no report on the development of relevant standards in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of preparation nano gamma-Fe 2 o 3 A method for a relaxation rate standard substance, comprising the following steps:

[0022] (1) Preparation of Fe by chemical co-precipitation method 3 o 4 nanoparticles

[0023] According to Fe 3+ and Fe 2+ Feed at a molar ratio of 2:1, and dissolve 54.05g of FeCl with 200ml of 2M hydrochloric acid solution with ultrasonic stirring 3 ·6H 2 O, added to a 3L single-layer glass reactor, stirred with nitrogen gas. Then use 50ml 2M hydrochloric acid solution to dissolve 27.80g FeSO under ultrasonic conditions 4 ·7H 2 O, then add the above Fe 3+ in solution. 1.25L of 12.5% ​​(CH 3 ) 4 The NOH aqueous solution was quickly added to the iron salt solution, and reacted at room temperature for 1 h. Then perform magnetic separation and wash once to obtain Fe 3 o 4 Nanoparticles for subsequent oxidation and surface modification.

[0024] (2) Chemical oxidation of Fe 3 o 4 Preparation of γ-Fe by Nanoparticles 2 o 3 nanop...

Embodiment 2

[0029] The relaxation rate is measured using a Siemens 1.5T magnetic resonance instrument for clinical use, and is measured according to the method specified in the specification of the present invention. The prepared samples were tested by the variance analysis method (F test method) and the mean consistency test method (T test method), which proved that the uniformity and stability were good, and the uncertainty S introduced by the sample inhomogeneity was calculated. H =0.88mM -1 ·S -1 , and the uncertainty S introduced by the sample stability T =4.91mM -1 ·S -1 .

[0030] According to "ISO Guide 35:2006, Reference materials-General and statistical principles for certification, IDT" and "GB / T 15000.3-94 Standard Sample Work Guidelines (3) General Principles and Statistical Methods for Standard Sample Valuation", the nanometer γ -Fe 2 o 3 Relaxation rate reference material is carried out many cooperative fixed value, and fixed value selects to have eight regular hospi...

Embodiment 3

[0032] Nano γ-Fe in the present invention 2 o 3 The relaxation rate standard substance is determined by the following method, and follows "ISOGuide 35:2006, Reference materials-General and statistical principles for certification, IDT" and "GB / T 15000.3-94 Standard Sample Work Guidelines (3) Standard Samples General Principles and Statistical Methods of Valuation.

[0033] (1) Uniformity detection: 15 bottles of samples were randomly selected, and the relaxation rate was measured by a Siemens 1.5T magnetic resonance instrument for clinical use. Each sample was repeatedly measured 3 times, and the uniformity was detected by variance analysis (F test method), and Calculate the uncertainty SH introduced by the sample inhomogeneity.

[0034] (2) Stability detection: use Siemens 1.5T magnetic resonance instrument to measure the relaxation rate of the sample at different times, use the average consistency test method (T test method) to carry out stability detection, and find out t...

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Abstract

The invention discloses a nanometer gamma-Fe2O3 relaxation rate standard substance and a preparation method thereof. The nanometer gamma-Fe2O3 relaxation rate standard substance is hydrophilic colloid solution of gamma-Fe2O3 nanoparticles, wherein, the relaxation rate constant value is 311.1mM<-1>.S-1, and the total uncertainty is 11.2mM<-1>.S-1. The preparation method comprises the following steps: preparing Fe3O4 nano-particles by a chemical coprecipitation process; preparing gamma-Fe2O3 nano-particles by chemically oxidizing the Fe3O4 nano-particles; and preparing dimercapto succinic acid surface modified gamma-Fe2O3 nano-particle hydrophilic colloid solution. The invention firstly provides the nanometer gamma-Fe2O3 relaxation rate standard substance which fills up home and abroad blank in the field, provides comparison standard for development, production and future application of MRI (magnetic resonance imaging) magnetic nano-particle contrast agent, and is important for development of accelerating and standardizing the field; meanwhile, the prepared nanometer gamma-Fe2O3 has high relaxation rate and stability, and has great application value as the MRI contrast agent.

Description

technical field [0001] The invention belongs to the technical field of measurement value transfer, in particular to nano-γ-Fe 2 o 3 The relaxation rate standard substance is proposed to meet the needs of the development, clinical and production quality control and evaluation of magnetic resonance nano-contrast agents. Background technique [0002] Magnetic nano-iron oxides (such as Fe 3 o 4 , γ-Fe 2 o 3 ) because of its rich magnetic properties and good biocompatibility, it is widely used in biomedical fields such as magnetic resonance imaging contrast agents, magnetic targeting drug carriers, separation of cells and biomolecules, biosensing and detection, and magnetic induction tumor hyperthermia. Wide range of applications. [0003] Magnetic resonance imaging (MRI) is one of the most important achievements in medical imaging developed since the 1980s after ultrasonic scanning imaging (such as B-ultrasound) and X-CT. It has the advantages of no ionizing radiation (ra...

Claims

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Application Information

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IPC IPC(8): A61K49/06A61K49/18C01G49/06
Inventor 张宇顾宁王春雨宋丽娜宋孟杰
Owner SOUTHEAST UNIV
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