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Dimercaptosuccinic acid granular formulation

A technology of dimercaptosuccinic acid and granules, which is applied in the directions of antidote, pill delivery, organic active ingredients, etc., can solve the problems of single type and poor compliance, and achieve the effect of good indicators.

Active Publication Date: 2012-01-25
HAINAN HONZ PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects of the single type of dimercaptosuccinic acid preparations in the prior art, especially poor drug compliance for children, the present invention provides a solid preparation of dimercaptosuccinic acid, especially dimercaptosuccinic acid granules

Method used

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  • Dimercaptosuccinic acid granular formulation
  • Dimercaptosuccinic acid granular formulation
  • Dimercaptosuccinic acid granular formulation

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Embodiment 1

[0052] Prescription: (W / W)

[0053]

[0054] Preparation Process:

[0055] 1. Pass dimercaptosuccinic acid and β-cyclodextrin through a 100-mesh sieve; the rest of the solid excipients pass through a 80-mesh sieve and store in a dry place. The moisture content of sucrose powder and beta-cyclodextrin must be controlled below 0.5% before use.

[0056] 2. Take the dimercaptosuccinic acid of the prescribed amount and place it in the high-speed stirring granulation pot, add the liquid cream flavor of the prescribed amount under stirring (150rpm of the main stirring blade, 800rpm of the cutting knife), stir for 5min, and then weigh into the β-cyclodextrin, stir for 5 minutes, take it out for later use, it is material A.

[0057] 3. Take stevioside, croscarmellose sodium and xanthan gum of the prescription amount respectively and put them into the high-speed stirring granulation pot, stir (150rpm of the main stirring blade, 800rpm of the cutting knife) for 5min, then add the rec...

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Abstract

The invention provides dimercaptosuccinic acid solid preparations, in particular to a dimercaptosuccinic acid granular formulation, which is prepared from dimercaptosuccinic acid and auxiliary materials, wherein the auxiliary materials are taste-masking preparation and one kind or more than two kinds of the following materials which are selected from the following groups: diluent, disintegrating agent, suspending agent, sweetener and bonding agent. The dimercaptosuccinic acid granular formulation is characterized in that the taste-masking preparation is beta-cyclodextrin and liquid cream flavor essence, and is prepared into the granular formulation through the following method: after the dimercaptosuccinic acid and the liquid cream flavor essence are mixed, and then the beta-cyclodextrin is added to be uniformly mixed. The dimercaptosuccinic acid granular formulation adopts the novel taste-masking technology, the garlic like smell of the dimercaptosuccinic acid is effectively masked, and meanwhile, the formulation has the pleasant fragrance and fruity taste, and is more suitable for children to take.

Description

technical field [0001] The invention relates to a dimercaptosuccinic acid solid preparation, in particular to a dimercaptosuccinic acid granule, and a preparation method thereof. It belongs to the field of pharmaceutical preparations. Background technique [0002] At present, the treatment methods adopted for heavy metal poisoning generally fall into two categories in terms of their mechanism of action. One is the mechanism of chelation (complexation), that is, the combination of chelating agents and heavy metal elements to form chelates, which are excreted with urine (such as dimercaptosuccinic acid); or form non-toxic or low-toxic chelation substances (such as metallothionein); or form insoluble complexes (such as natural polymers such as pectins). The other is the mechanism of repulsion (antagonism). For example, elements such as calcium, iron, zinc and lead belong to divalent metal elements. They have a competitive effect in the metabolic process in the body and compet...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/191A61K47/40A61P39/04
Inventor 王稳奇洪丽萍凌日金洪江游
Owner HAINAN HONZ PHARMA
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