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30results about How to "Meet clinical drug needs" patented technology

Tibetan-medicine three-component Tibet inula soup-granula composition and preparation process thereof

The invention relates to a Tibetan medicine, and particularly relates to a Tibetan-medicine three-component Tibet inula soup-granula composition and a preparation process thereof. The composition disclosed by the invention is prepared from the following raw materials in parts by weight: Ramulus Rubi, Tinospora sinensis and Tibet inula in a proportion of 2:1:1. The preparation process comprises the following steps: 1) carrying out superfine grinding on the Tibet inula; 2) placing the Tinospora sinensis and the Ramulus Rubi in a multifunctional extraction pot to decoct, filtering and concentrating to obtain an aqueous extract, and drying the aqueous extract by using a centrifugal spray drier; 3) combining dry cream powder with micro-powder; and 4) adding ethanol into the obtained powder, preparing into a soft material, granulating the soft material by using a granulator, drying, and carrying out straightening granulation to obtain the composition. According to the composition disclosed by the invention, when the quality of Tibetan medicines is improved, due to the reference and introduction of some new processes, new techniques and new devices, the stability and bioavailability of preparations can be improved, and traditional Tibetan medicine and modern preparation methods are combined, thus a way for the rational development of Tibetan medicines is explored.
Owner:多杰 +3

Altrenogest nanometer emulsion and method for preparing same

The invention provides altrenogest nanometer emulsion and a method for preparing the same. The altrenogest nanometer emulsion comprises, by weight, 0.1-1 part of altrenogest, 15-35 parts of surfactants, 1.5-20 parts of auxiliary surfactants, 2-30 parts of oil and 26-45 parts of water for injection. The altrenogest nanometer emulsion and the method have the advantages that the altrenogest nanometer emulsion is good in thermodynamic stability, stable emulsion states can be completely recovered after the altrenogest nanometer emulsion is heated until the temperature of the altrenogest nanometer emulsion reaches 80 DEG C, then the altrenogest nanometer emulsion is allowed to stand still and then is sufficiently vibrated, the altrenogest nanometer emulsion is good in storage stability, layering can be prevented after the altrenogest nanometer emulsion is allowed to stand for a long time, the altrenogest nanometer emulsion not only can be orally administered by the aid of drinking water, but also can be administered after being mixed with materials, oral administration nano-emulsion substrates can effectively protect the altrenogest from being damaged by gastric acid, and the shortcoming of first-pass effects of livers can be overcome; the method for preparing the altrenogest nanometer emulsion is simple, and accordingly requirements of large-scale industrial production can be met.
Owner:TIANJIN ZHONGSHENG TIAOZHAN BIOTECH

Formula for Tibetan medicines for treating gynecological qi diseases, medicinal liquor for treating same and process for preparing medicinal liquor

InactiveCN107854684ATibetan medicine works fastGood curative effectNervous disorderDispersion deliveryYeastDisease
The invention belongs to the field of technologies for preparing medicines and Tibetan medicines, and relates to a formula for Tibetan medicines for treating gynecological qi diseases, medicinal liquor for treating the same and a process for preparing the medicinal liquor. Medicinal materials, water and distiller's yeast in the formula are fermented, extracted and processed to obtain the medicinalliquor with the Tibetan medicines. The Tibetan medicines in the formula comprise, by weight, 3000-5000 parts of honey, 5-8 parts of gypsum rubrum, 2-4 parts of elettaria cardamomum, 2-4 parts of rhizoma podophylli emodi, 2-4 parts of fructus piperis longi, 2-5 parts of pimenta and 2-5 parts of rhizoma zingiberis. The process for preparing the medicinal liquor with the Tibetan medicines includes honey water preparing, distiller's yeast medicinal material package manufacturing, fermentation, extraction, disinfection and filling working procedures. The formula, the medicinal liquor and the process have the advantages that the medicinal liquor with the Tibetan medicines has functions of expelling wind, clearing heat, astringing yellow liquid and regulating menstruation and is applicable to endocrine disorder, irregular menstruation, insomnia and forgetfulness and cold backs due to the gynecological qi diseases and skin itch due to qi bone heat, kidney heat and yellow liquid in joints; theTibetan medicines and the medicinal liquor are stable in quality, and obvious curative effects can be realized.
Owner:索南扎西

Metoprolol succinate sustained-release tablet and preparation method thereof

The present invention provides a metoprolol succinate sustained-release tablet and a preparation method thereof. Metoprolol succinate sustained-release particles are firstly prepared by adopting a hot melting process, and then the metoprolol succinate sustained-release tablet is prepared by granulating and tabletting the sustained-release particles, a disintegrating agent and other additional auxiliary materials. The metoprolol succinate sustained-release tablet provided by the invention has dissolution consistency before and after breaking under the condition that the metoprolol succinate sustained-release tablet is broken off by a patient according to the doctor's advice, can avoid the problem that a sustained-release particle coating layer in the existing sustained-release tablet is easy to break during tablet pressing, can significantly simplify the production process, and reduces the manufacturing cost of a unit preparation, and the clinical medication requirements under the condition of medical insurance cost control in China are met.
Owner:北京联嘉医药科技开发有限公司

Diphosphonic acid drug for inhalation and preparation method thereof, and application of diphosphonic acid drug in chronic obstructive pulmonary diseases

ActiveCN111053761AGood bronchiectasisReduce airway resistanceDispersion deliveryInorganic non-active ingredientsBicarbonateDisease
The invention discloses a diphosphonic acid drug for inhalation and a preparation method thereof, and application of the diphosphonic acid drug in chronic obstructive pulmonary diseases. A formula ofa drug solution comprises the diphosphonic acid drug, a pH regulator and an osmotic pressure regulator, wherein a pH value is in a range of 8.2-8.9; osmotic pressure is isoosmotic or hyperosmotic pressure; preferably, the pH regulator and the osmotic pressure regulator are bicarbonate; and based on extracellular application concentration, the content of the diphosphonic acid drug is 0.1-100 [mu]M,and the content of the bicarbonate is 1.5% (w / v)-4.0% (w / v). A drug dose researched by the invention is effective and safe, and can meet the clinical medication requirements of diseases such as the chronic obstructive pulmonary diseases.
Owner:HANGZHOU DC PHARM CO LTD

Preparation method for blood-activation stasis-dissipation orifices-opening pain-relieving traditional Chinese medicine composition

A preparation method for a blood-activation stasis-dissipation orifices-opening pain-relieving traditional Chinese medicine composition includes the following steps: crushing salvia miltiorrhiza coarsely, extracting effective active ingredients by using a supercritical carbon dioxide fluid, precipitating for separation, drying under vacuum to get a dry extract, crushing the dry extract into a fine powder, crushing panax notoginseng, ginseng fibrous root and safflower into a fine powder by adopting a traditional Chinese medicine ultrafine pulverizer, grinding cultivated bezoar or in-vitro cultivated bezoar, cake of toad skin secretion and borneol into a fine powder, mixing the obtained three fine powders with a cornu bubali concentrated powder, carrying out granulation and screening with 14 mesh sieve, drying at 50-60 DEG C, finishing granules, filling into capsules, and packaging. By adopting the preparation method, the production process is controllable, extraction speed is fast, the product has no residual toxicity, the product is high in purity, the disadvantages of large extraction rate and lots of impurities in conventional water extraction method are overcome, and at the same time using cultivated bezoar or in-vitro cultivated bezoar can make up for the lack of a raw material of natural bezoar to meet the needs of clinical medication.
Owner:湖南恒伟药业股份有限公司

Qi benefiting and viscosity breaking particle and preparation method thereof

The invention relates a qi benefiting and viscosity breaking particle and a preparation method thereof. The particle comprises accessory dextrin and also the ingredients of 50-65 percent of radix astragali, 20-30 percent of ligusticus wallichii franchet, and 10-20 percent of earthworm according to weight percentage. The preparation steps include: decocting the three crude drugs of radix astragali, ligusticus wallichii franchet and earthworm with water added for extraction for three times, wherein in the first time, adding water 10 times of the amount of the drugs, decocting for 1-2h, and adding water 8 times of the amount of the drugs and decocting for 0.5-2h in the second and third times; combining and filtering the decoction liquid, precipitating statically for 24-72h, and sucking supernatant fluid, conducting reduced pressure concentration till the extract with the specific weight of 1.18 is obtained; adding a proper amount of dextrin to make soft material which then passes through a 12-mesh sieve, drying, conducting size stabilization, making the material into finished product, packing and obtaining the qi benefiting and viscosity breaking particle. The particle has no toxic or side effect and can reduce blood viscosity while lowering lipid.
Owner:ANHUI RONGYUANTANG BIO TECH
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