30results about How to "Meet clinical drug needs" patented technology

The invention relates to a 3-n-butylphthalide injection and a preparation method thereof. The 3-n-butylphthalide injection disclosed by the invention comprises 3-n-butylphthalide or a derivant thereof, a surfactant and water for injection, wherein the surfactant is selected from one or more of phospholipid, polyethylene glycol-12-hydroxy stearate, polyethylene glycol-VE (Vinyl Ether) carbonic ester, polyethylene glycol-VE succinate, polyethylene glycol-DSPE (distearoyl phosphoethanolamine), polyethylene glycol-cholesteryl hemisuccinate, polyethylene glycol-cholesterol methyl ester, polyethylene glycol-cholesterol sulfate, polyoxyethylene dehydration sorbitol fatty acid ester and poloxamer. By adopting the 3-n-butylphthalide injection disclosed by the invention, a special fragrance of the 3-n-butylphthalide can be effectively concealed; the 3-n-butylphthalide injection is stable in quality, high in 3-n-butylphthalide content, simple in preparation technology, strong in operability and beneficial to industrialization, can be separately subpackaged into small volume of preparation, can be applied to intravenous injection, and also can be applied to intramuscular injection; the clinical drug delivery requirements are met.

The invention provides Tibetan medicine of Zuotai and a processing method thereof, and belongs to the field of Tibetan medicine processing. The processing method comprises the following steps that sulfur by water extraction liquid of rhizoma acori tatarinowii and rhizome imperatae sespia esculenta is steamed and boiled for 2 to 4h; soaking is performed for 18 to 30h; then, the sulfur is covered into blocks; the blocks are flushed and soaked by water for 6 to 8 days; sulfur powder is obtained after drying and crushing; mercury subjected to rust removal and detoxifcation is mixed with the sulfur powder; grinding is performed for 18 to 30h; then, obtained materials are mixed with metal ash, biotite ash, seven-mineral ash and pomegranate water extraction liquid; grinding is performed for 18 to 30h; then, drying is performed. The processing method has the advantages that the process stability is high; the quality is controllable; the processing cost is low; the Zuotail obtained by the processing method has low toxicity and strong medicine effect; the problem of medication safety of the Zuotai is effectively solved; the clinic medication requirements are met.

A vaginal effervescent tablet with high release speed and no irritation is prepared from achamydeous beautyberry leaf, effervescent agent and auxiliary. Its preparing process is also disclosed.

The invention discloses a lipid microballoon injection solution for a progestational hormone drug and a preparation method thereof. The lipid microballoon injection solution for the progestational hormone drug comprises progestational hormone drug progesterone as a primary drug and pharmaceutically acceptable drug excipient, wherein the drug excipient comprises oil phase, emulsifier, osmotic pressure adjusting agent, stabilizer, pH value modifier and injection water. The lipid microballoon injection solution for the progestational hormone drug is stable in quality, free from injection irritation, high in safety, applicable to local intramuscular injection and intravenous injection, and beneficial to promotion of compliance of clinical medication of patient and enriches clinical medication selection.

The invention provides altrenogest nanometer emulsion and a method for preparing the same. The altrenogest nanometer emulsion comprises, by weight, 0.1-1 part of altrenogest, 15-35 parts of surfactants, 1.5-20 parts of auxiliary surfactants, 2-30 parts of oil and 26-45 parts of water for injection. The altrenogest nanometer emulsion and the method have the advantages that the altrenogest nanometer emulsion is good in thermodynamic stability, stable emulsion states can be completely recovered after the altrenogest nanometer emulsion is heated until the temperature of the altrenogest nanometer emulsion reaches 80 DEG C, then the altrenogest nanometer emulsion is allowed to stand still and then is sufficiently vibrated, the altrenogest nanometer emulsion is good in storage stability, layering can be prevented after the altrenogest nanometer emulsion is allowed to stand for a long time, the altrenogest nanometer emulsion not only can be orally administered by the aid of drinking water, but also can be administered after being mixed with materials, oral administration nano-emulsion substrates can effectively protect the altrenogest from being damaged by gastric acid, and the shortcoming of first-pass effects of livers can be overcome; the method for preparing the altrenogest nanometer emulsion is simple, and accordingly requirements of large-scale industrial production can be met.

The invention belongs to the field of technologies for preparing medicines and Tibetan medicines, and relates to a formula for Tibetan medicines for treating gynecological qi diseases, medicinal liquor for treating the same and a process for preparing the medicinal liquor. Medicinal materials, water and distiller's yeast in the formula are fermented, extracted and processed to obtain the medicinalliquor with the Tibetan medicines. The Tibetan medicines in the formula comprise, by weight, 3000-5000 parts of honey, 5-8 parts of gypsum rubrum, 2-4 parts of elettaria cardamomum, 2-4 parts of rhizoma podophylli emodi, 2-4 parts of fructus piperis longi, 2-5 parts of pimenta and 2-5 parts of rhizoma zingiberis. The process for preparing the medicinal liquor with the Tibetan medicines includes honey water preparing, distiller's yeast medicinal material package manufacturing, fermentation, extraction, disinfection and filling working procedures. The formula, the medicinal liquor and the process have the advantages that the medicinal liquor with the Tibetan medicines has functions of expelling wind, clearing heat, astringing yellow liquid and regulating menstruation and is applicable to endocrine disorder, irregular menstruation, insomnia and forgetfulness and cold backs due to the gynecological qi diseases and skin itch due to qi bone heat, kidney heat and yellow liquid in joints; theTibetan medicines and the medicinal liquor are stable in quality, and obvious curative effects can be realized.

The invention discloses a pharmaceutical composition for treating respiratory system diseases and a preparation method thereof. The composition comprises the following components: a bronchiectasis agent, acetylcysteine, a stabilizer, an osmotic pressure regulator, a pH regulator, a dispersion medium and inert gas, wherein the bronchiectasis agent is a beta2 adrenergic receptor agonist or an anti-choline drug. The stability of the pharmaceutical composition is improved by adding the stabilizer and filling the inert gas in the composition of the pharmaceutical composition so that the pharmaceutical composition is convenient to store, transport and use.

The invention relates a qi benefiting and viscosity breaking particle and a preparation method thereof. The particle comprises accessory dextrin and also the ingredients of 50-65 percent of radix astragali, 20-30 percent of ligusticus wallichii franchet, and 10-20 percent of earthworm according to weight percentage. The preparation steps include: decocting the three crude drugs of radix astragali, ligusticus wallichii franchet and earthworm with water added for extraction for three times, wherein in the first time, adding water 10 times of the amount of the drugs, decocting for 1-2h, and adding water 8 times of the amount of the drugs and decocting for 0.5-2h in the second and third times; combining and filtering the decoction liquid, precipitating statically for 24-72h, and sucking supernatant fluid, conducting reduced pressure concentration till the extract with the specific weight of 1.18 is obtained; adding a proper amount of dextrin to make soft material which then passes through a 12-mesh sieve, drying, conducting size stabilization, making the material into finished product, packing and obtaining the qi benefiting and viscosity breaking particle. The particle has no toxic or side effect and can reduce blood viscosity while lowering lipid.