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Preparation method for blood-activation stasis-dissipation orifices-opening pain-relieving traditional Chinese medicine composition

A technology for relieving pain, promoting blood circulation and dissipating blood stasis, which can be used in drug combinations, pharmaceutical formulations, non-central analgesics, etc., to solve the problems of large loss of active ingredients, difficult separation and purification, and unsatisfactory effects, achieving no residual toxicity, overcoming The ointment rate is large, and the effect of meeting the needs of clinical medication

Inactive Publication Date: 2013-09-25
湖南恒伟药业股份有限公司
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AI Technical Summary

Problems solved by technology

Studies have shown that using the water extraction method to extract the active ingredients of Salvia miltiorrhiza, the effect is not ideal, the cream yield is high, the time is long, the extraction efficiency is low, separation and purification are difficult, not only the loss of active ingredients is large, but the purity is also low

Method used

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Embodiment 1

[0009] The preparation method of the traditional Chinese medicine composition of promoting blood circulation, dispelling blood stasis, resuscitation and relieving pain of the present embodiment comprises the following steps: weighing the following raw materials of Chinese medicines in parts by weight: 732 parts of Danshen, 141.6 parts of Panax notoginseng, 94.4 parts of ginseng root, 48.4 parts of safflower, 47.2 parts of concentrated buffalo horn powder, 6.3 parts of cultivated bezoar or in vitro cultured bezoar, 0.79 part of toad venom, and 1.22 parts of borneol; the salvia miltiorrhiza is roughly crushed, passed through a 10-mesh sieve, and its active ingredients are extracted with supercritical carbon dioxide fluid. The extraction process conditions are as follows: The extraction pressure is 30MPa, the extraction temperature is 46°C, the extraction time is 100 minutes, the separator pressure is 6.0MPa, the separator temperature is 37°C, the carbon dioxide flow rate is 78L / H,...

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Abstract

A preparation method for a blood-activation stasis-dissipation orifices-opening pain-relieving traditional Chinese medicine composition includes the following steps: crushing salvia miltiorrhiza coarsely, extracting effective active ingredients by using a supercritical carbon dioxide fluid, precipitating for separation, drying under vacuum to get a dry extract, crushing the dry extract into a fine powder, crushing panax notoginseng, ginseng fibrous root and safflower into a fine powder by adopting a traditional Chinese medicine ultrafine pulverizer, grinding cultivated bezoar or in-vitro cultivated bezoar, cake of toad skin secretion and borneol into a fine powder, mixing the obtained three fine powders with a cornu bubali concentrated powder, carrying out granulation and screening with 14 mesh sieve, drying at 50-60 DEG C, finishing granules, filling into capsules, and packaging. By adopting the preparation method, the production process is controllable, extraction speed is fast, the product has no residual toxicity, the product is high in purity, the disadvantages of large extraction rate and lots of impurities in conventional water extraction method are overcome, and at the same time using cultivated bezoar or in-vitro cultivated bezoar can make up for the lack of a raw material of natural bezoar to meet the needs of clinical medication.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicine composition for promoting blood circulation, dispelling blood stasis, resuscitating one's ideas and relieving pain. Background technique [0002] The ninth volume (WS3-B-1714-94) of the drug standard of the Ministry of Health "Chinese Medicine Prescriptions" records a kind of Xinkening capsule. g, toad cake 0.79g, safflower 48.4g, bezoar 6.3g, ginseng root 94.4g, preparation method: the above eight flavors, red ginseng, boiled in water for 3 hours, filtered, and the filtrate was concentrated to an appropriate amount, and ginseng root and notoginseng were taken separately , safflower, crushed into coarse powder, mixed with concentrated salvia miltiorrhiza, dried, crushed into fine powder, sieved, then mixed with bezoar, buffalo horn concentrated powder, toad, and borneol, mixed and ground ev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/537A61P29/00A61K35/413
Inventor 吕宏再
Owner 湖南恒伟药业股份有限公司
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