Periplaneta americana extract enteric-coated preparation and preparation method thereof

An enteric-coated preparation, the technology of Periplaneta americana, applied in the field of enteric-coated preparation of Periplaneta americana extract and its preparation, can solve problems such as easy burst release or delayed release

Active Publication Date: 2020-07-07
INNER MONGOLIA JINGXIN PHARMACEUTICAL CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the defect that the enteric-coated preparation of Periplaneta americana exists in the prior art, which is easy to burst or delay release, and provides an enteric-coated preparation of Periplaneta americana extract and its preparation method

Method used

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  • Periplaneta americana extract enteric-coated preparation and preparation method thereof
  • Periplaneta americana extract enteric-coated preparation and preparation method thereof
  • Periplaneta americana extract enteric-coated preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Preparation of Kangfuxin enteric-coated pellets and capsules

[0062] (1) Preparation of blank core

[0063] Microcrystalline Cellulose 400g

[0064] 10% ethanol aqueous solution 400g

[0065] Weigh microcrystalline cellulose and 10% ethanol according to the prescription amount, fully knead and mix the prescription amount of microcrystalline cellulose, add 10% ethanol and continue mixing to obtain a soft material, and slowly put the soft material into the extruder In the funnel, adjust the extrusion speed to be 35rpm to extrude to obtain a strip-shaped soft material. Put the strip-shaped soft material in the spheronizer, adjust the spheronization speed to 800rpm, and spheronize for 10 minutes. The obtained pellet cores are dried in an oven at 40°C for 2 hours to obtain blank pellet cores. The blank pellet cores are obtained by extrusion spheronizer Screening is carried out, and pellets with a particle size of 0.4-1.2 mm are selected for drug-loading layer ...

Embodiment 2

[0074] Example 2: Preparation of Kangfuxin enteric-coated pellets and capsules

[0075] Example 2 On the basis of Example 1, the use of the disintegrant cross-linked povidone XL was omitted. In addition, the enteric coating layer was prepared, the amount of Eudragit S100 was 125g, and the coating weight of the enteric coating was increased 25%. Other raw material formulas and preparation steps, process conditions are all with embodiment 1.

Embodiment 3

[0076] Example 3: Preparation of Kangfuxin enteric-coated pellets and capsules

[0077] (1) Preparation of drug-loaded pellet core

[0078] Commercially available fast-collapsing micro-pill core 300g (purchased from Hangzhou Gaocheng Bio-Nutrition Technology Co., Ltd., model: fast-collapsing MCC pellets)

[0079] Hypromellose E5 90g

[0080] American cockroach extract (by dry weight) 180g

[0081] Micronized silica gel 30g

[0082] Weigh 90g of hypromellose E5, add 810ml of purified water, heat to 80°C, stir until completely dissolved, and cool to room temperature. Weigh 180 g of Periplaneta americana extract (by dry weight), add the above solution, stir evenly, and finally add 30 g of micropowder silica gel to obtain the drug-containing coating solution. Weigh the core of the prescribed amount, and use a fluidized bed to coat the drug-loaded layer. The coating amount of the drug-containing coating is 100% of the prescribed amount. During the coating process, the agitator ...

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Abstract

The invention discloses a periplaneta americana extract enteric-coated preparation and a preparation method thereof. Sequentially, the release amount of the enteric-coated preparation in artificial gastric juice within 2 hours is not more than 10%, the release amount of the enteric-coated preparation in artificial intestinal juice within 1 hour is not more than 10%, and the release amount of the enteric-coated preparation in artificial colonic juice within 1 hour is not less than 90%; the enteric-coated preparation comprises medicine-containing coated granules; and the outer surfaces of the medicine-containing coated granules are coated with enteric coatings. The enteric-coated preparation provided by the invention has the advantages of almost no release in the stomach, quick release in the intestinal tract environment, stable release, high bioavailability and the like, the requirements of existing clinical medication can be met, and the preparation process is simple and convenient.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a pharmaceutical preparation with an extract of the American cockroach as an active ingredient, an enteric-coated preparation of the extract of the American cockroach and a preparation method thereof. Background technique [0002] Ulcerative colitis is a chronic non-specific intestinal inflammatory disease caused by unknown reasons (diet, living habits, etc.), which belongs to autoimmune diseases. The main clinical manifestations are persistent or recurrent diarrhea, mucus, pus and blood in the stool accompanied by abdominal pain, and tenesmus. Under the colonoscope, the texture of mucosal vessels is blurred, disordered or disappears, hyperemia, edema, brittle texture, hemorrhage, purulent secretion adhesion, rough mucosa and fine granules are also common; diffuse, multiple erosions or ulcers can be seen in obvious lesions . [0003] Clinically, the drugs for ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K35/64A61K47/38A61K47/32A61P1/04
CPCA61K35/64A61K9/5078A61K9/5047A61K9/5026A61P1/04Y02A50/30
Inventor 刘力于垂亮吕署一李尚蓉侯建
Owner INNER MONGOLIA JINGXIN PHARMACEUTICAL CO LTD
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