57 results about "Drug excipient" patented technology

The invention relates to the plant extract and health tea technical field, in particular to coreopsis tinctoria extract and coreopsis tinctoria health instant tea and a production method thereof. The coreopsis tinctoria extract is obtained through the following steps that step 1: coreopsis tinctoria powder is obtained; and step 2 coreopsis tinctoria extract is obtained. The coreopsis tinctoria health instant tea is prepared through the following steps that the coreopsis tinctoria extract is uniformly mixed with concentrated liquid and drug excipient or edible excipient according to an equivalent mass, then the mixture is granulated by a granulation machine, and finally the prepared pellets are dried to obtain the coreopsis tinctoria health instant tea. The invention has advantages that biologically active ingredients of coreopsis tinctoria are adequately utilized, hygiene and convenience in use are realized, taste is good, and the application effect is good.

The invention discloses a method for preparing nano cellulose by simultaneous assistance of ultrasonic waves and microwaves, belonging to the field of biomass nano materials. According to the nano material, liquid acid is taken as a catalyst, and the high-efficiency hydrolysis at the amorphous area of cellulose is promoted due to the simultaneous assistance of the ultrasonic waves and microwaves, so that the nano cellulose is rapidly prepared by plant fiber raw materials. The preparation method comprises the steps of acid hydrolysis of plant cellulose, centrifugal recovery of liquid acid and centrifugal separation of nano cellulose. According to the method, the mechanical dispersion action and ultrasonic cavitation effect of the ultrasonic waves, microwave uniform heating effect, catalytic action of the liquid acid and the synergistic effect of the ultrasonic waves and microwaves are utilized sufficiently, and the hydrolytic process of cellulose is enhanced, so that the high-efficiency and rapid preparation of the nano cellulose can be realized. The prepared nano cellulose material can be used for food additives, drug excipients, engineering material additives, specialty paper additives and the like.

The invention provides the application of betulinic acid and salts thereof suitable for medical purpose in the preparation of a drug of a glycosidase inhibitor. The compound of the invention is the compound of lupeol type pentacyclic triterpene acid obtained by separating lagerstroemia plants. Pharmacological tests prove that the compound has obvious effect in inhibiting Alpha-glucosidase, the inhibitory activity of which exceeds acarbose 100% for initial therapy. Therefore, drug compositions made from the compound or the salts thereof suitable for medical purpose and drug excipients or carriers allowable for preparation can be applied to the preparation of drugs for preventing or treating Type II Diabetes, namely, noninsulin-dependent diabetes mellitus. The constitutional formula shown in formula (1) of the invention is shown as above.

The present invention provides an application of curcumin in preparation of tumor multi-drug drug-resistance preventing preparation. Its CAS mumber is 458-37-7, molecular weight is 368.37, chemical name is 1,7-bis-(4-hydroxy- 3-methoxyphenyl)-1,6-heptadiene-3,5-dione and its molecular formula is C21H2006. The curcumin drug prepared by said invention includes preparation allowable drug excipient and carrier.

The invention provides the application of a paris saponin (I) and a ramification of the paris saponin (I) in the preparation of a drug for remedying the tumor. The chemical name of the paris saponin (I) is 4-O-furan Arabian glycosyl-2-O-pyran buckthorn glycosyl-beta-D-pyran glucosyl dioscorea saponin, and the molecular formula of the paris saponin (I) is C44H70O16. The drug, which is prepared by the invention, also contains a drug excipient or carrier which is allowed by the preparation. The invention is mainly applied to prepare the drugs for remedying the lung cancer and the leukaemia and has strong anticancer effect, and the animal experiment testifies that the effect of resisting the growth of the cancer cells of the paris saponin (I) is obviously better than a chemotherapeutic drug of cisplatin which is in common clinical use at present. The toxic and side effect of the paris saponin (I) is light, and the experiment of cell culture in vitro testifies that the paris saponin (I) and the ramification of the paris saponin (I) do not have obvious toxic and side effect towards the growth of the hematopoietic cells of the normal person under the quantity of an antineoplastic and are better than the normal chemotherapeutic drug.

The invention relates to a composition having effects of whitening, removing spots and refreshing skin. The composition is obtained by uniformly mixing powder of ginkgetin extracted from ginkgo leaves, powder of sesamin extracted from sesame seed meal and powder of astragalosides extracted from radix astragali according to a mass ratio of (1-10): (1-10): (1-10). The composition and make-up preparations or drug excipients can be mixed into an external skin preparation such as cream, an emulsion, gel, paste and a subcutaneous injection. A pharmacological test research shows that the composition has effects of inhibiting skin tyrosinase activity and melanin generation. A clinical trial shows that the composition has obvious whitening, spot-removal and skin-refreshing effects on people having a medium yellow facial color and facial color spots, has an effective rate of 100%, is safe and has no side-effect.

The invention provides a use of brusatol in preparation of drugs for resisting tumor angiogenesis. Brusatol is known as brusatol, CAS No. 14907-98-3 and has a molecular formula of C26H32O11 and molecular weight of 520.54. The brusatol drug can promote degradation of a hypoxia-inducible factor-1 alpha (HIF-1 alpha), inhibit activation of HIF-1 signaling pathway and expression of a vascular endothelial growth factor (VEGF) and effectively inhibit the angiogenesis of tumors, has low toxicity and has a very good clinical application prospect. The brusatol drug comprises a pharmaceutically acceptable drug excipient or carrier. The dosage forms of the brusatol drug mainly comprise enteric or parenteral combined drug dosage forms. The brusatol drug can be processed to form a liquid preparation, granules, tablets, electuary, gelatin pills, capsules, dripping pills or an injection.

The invention discloses an anti-cancer drug prepared by using a 3D printing technology, and a method. The method comprises: uniformly mixing an anti-cancer drug, a high polymer material, and a drug excipient, extruding obtained mixture through an extruding machine, to obtain a wire rod containing drug; using computer design software to design a structure model of the anti-cancer drug, storing the structure model in a file format which can be identified by a 3D printer, importing the file into the 3D printer, using hierarchical software to perform hierarchical processing; respectively importing the high polymer material and the obtained wire rod containing drug into the 3D printer, selecting the drug structure model, setting printing precision, velocity, and temperature, to obtain the 3D printed anti-cancer drug. The method is characterized in that the method is convenient and fast and is simple in operation, and the size and shape of a tablet can be designed according to variation of weather and climate. The method can make tablets in different sizes and shapes, and utilization rate of the drug can be effectively improved.

The invention relates to an antiviral influenza drug and a preparation method of the antiviral influenza drug. The drug comprises the following ingredient by weight: 8-12 parts of ephedra, 8-12 parts of cassia twig, 5-7 parts of processed licorice root, 8-12 parts of semen armeniacae amarae, 8-12 parts of ginger, 18-22 parts of Chinese-date and 18-22 parts of gypsum. The preparation method comprises the steps of soaking the cassia twig and the ginger, extracting to obtain volatile oil and liquid medicine for standby application; then mixing the drug dregs and other crude drugs, extracting to obtain liquid medicine, mixing the liquid medicines obtained from the above two steps, then concentrating, spraying and drying to obtain a drug extract; and finally, mixing the extract with a pharmaceutically acceptable carrier or a drug excipient according to proportion, pelletizing and drying, and adding the standby volatile oil to prepare the antiviral influenza drug. The antiviral influenza drug has obvious curative effect, can be used in large range, and is convenient to take, accurate in curative effect, controllable in quality, simple in manufacturing process flow, controllable in quality standard, energy-saving in energy resources, free from environment pollution, small in potential safety hazard, and suitable for industrial production.

The invention discloses application of polypeptide specific-binding TRB3 in treating or preventing abdominal aortic aneurysm. The amino acid sequence of the polypeptide is showed as SEQ ID NO:1. The polypeptide derivative is a chimeric peptide formed by the polypeptide connecting with a cell penetrating peptide or a dosage form formed by the polypeptide coordinated with a drug excipient. The polypeptide is screened by the surface plasma resonance (Biacore) method, and can specifically bind to TRB3 and blockade the combination of TRB3 and P62 protein. Meanwhile, the polypeptide derivative Pep2-A2 can treat the mice abdominal aortic aneurysm by knocking-out ApoE inducted by angiotensin II. Thus, the polypeptide and the polypeptide derivative can be used as a novel inhibitor for TRB3, and can be used in exploiting vaccine or medicament for inhibiting abdominal aortic aneurysm.

The invention provides a preparation method and application of Nepeta bracteata total flavonoids. The method comprises the steps of conducting extraction with hydrous ethanol to the Uygur Nepeta bracteata, conducting macroporous resin enrichment to acquire the Nepeta bracteata total flavonoids. The total flavonoids content accounts for no less than 68% of the Nepeta bracteata total flavonoids extracts. The Nepeta bracteata total flavonoids have the functions of anti-inflammation, anti-coughing, phlegm elimination and asthma relief. The preparation with Nepeta bracteata total flavonoids as the main material, and with the incorporation of a variety of additional drug excipients, can be used for the therapy of influenza, pneumonia, bronchitis and asthma. The preparation method has the advantages of being simple and safe, being good in repeatability, and having no pollution, thus being suitable for large scale production.

The invention discloses a lipid microballoon injection solution for a progestational hormone drug and a preparation method thereof. The lipid microballoon injection solution for the progestational hormone drug comprises progestational hormone drug progesterone as a primary drug and pharmaceutically acceptable drug excipient, wherein the drug excipient comprises oil phase, emulsifier, osmotic pressure adjusting agent, stabilizer, pH value modifier and injection water. The lipid microballoon injection solution for the progestational hormone drug is stable in quality, free from injection irritation, high in safety, applicable to local intramuscular injection and intravenous injection, and beneficial to promotion of compliance of clinical medication of patient and enriches clinical medication selection.

The invention provides application of nestorone (16-methylene-17alpha-acetyloxy-19-norpregn-4-ene-3, 20-dione, nes) to preparation of neuroprotective drugs for improving and treating Parkinson's disease. The prepared drugs contain preparation-allowable drug excipients or carriers. The drugs can be made into the forms of liquid, particle, controlled release formulation, electuary, tablet or capsule. In terms of cells, the neuroprotective drugs and application thereof using nestorone to improve and treat Parkinson's disease are demonstrated, and the curative effect of the neuroprotective drugs compared with progesterone on improving and treating Parkinson's disease is better, and the toxic and side effects to nervous systems are low.

The invention relates to a composition with slimming function. The composition is prepared by uniformly mixing gingko flavone powder extracted from ginkgo leaf, sesamin powder extracted from sesame pulp and radix astragali total glycoside powder extracted from radix astragali in a mass ratio of (1-10):(1-10):(1-10). The composition can be mixed with a cosmetic preparation or drug excipient to prepare an external preparation for skin, such as cream emulsion, gel, film, subcutaneous injection or the like. The pharmacological test indicates that the composition has the functions of lowering weight, reducing body fat and lowering the quantity and volume of fat cells, and has the effects of lowering the blood sugar and lowering the blood fat; and the composition of the gingko flavone powder, sesamin powder and radix astragali total glycoside powder can synergically enhance the physiological activity, and better enhances the respective functions. The trial result on fat people indicates that the composition has the functions of lowering weight and eliminating fat; the effective rate reaches 100%; and the composition is safe to use and has no side effect.

Disclosed are innovative drug excipient compressible sucrose and a preparation method thereof. The innovative drug excipient compressible sucrose is prepared by taking 79.8-94.2% of sucrose, 2.5-14.5% of dextrin, 1.5-14.0% of starch and 1.5-2.5% of silica. The compressible sucrose prepared is high in fluidity, compressibility, drug dissolving quantity and dissolution speed; the compressible sucrose is produced at low temperature, so that color, smell and taste that sucrose should have are retained, chewing sense is improved, and the compressible sucrose is especially suitable for buccal tablets and chewable tablets.

The invention discloses a Chinese medicinal composition preparation and a preparation method and a quality control method thereof, particularly discloses a Chinese medicinal composition preparation with effects of clearing away heat and toxic material and diminishing inflammation and a preparation method and a quality control method thereof. The Chinese medicinal composition preparation comprises the following raw materials by weight portion: 10 to 50 portions of extract of honeysuckle flower; 5 to 30 portions of extract of baical skullcap root; 60 to 180 portions of dextrin; and 0.5 to 2.0 portions of steviosin. The Chinese medicinal composition sugar-free granules replace the conventional sucrose and starch in the conventional process with dextrin and steviosin so as to not only have the characteristics of the common granules, but also have the advantages of good stability of the medicament, dosage reduction of the drug excipient, image improvement of the Chinese medicinal preparation, curative effect strengthening and the like. The invention also discloses a method for measuring the content of chlorogenic acid and the content of baicalin and testing microbial limit. The experiments prove that the testing specificity is good, the stability is high, the repeatability is good, and the precision is high.

The invention relates to a new veterinary medicine preparation (sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection) and a preparation method thereof; the new veterinary medicine preparation is prepared by taking sulfamonomethoxine or sulfamonomethoxine sodium as main drug and other excipients for assist. The percentage of the main ingredients in the suspension is as follows: 1%-50% (W / V) of sulfamonomethoxine or sulfamonomethoxine sodium and the rest of drug excipients; the excipients include a suspending agent and a disperse medium. The invention takes oil solvent as the disperse medium to prepare sulfamonomethoxine or sulfamonomethoxine sodium into a long-acting and sustained-release preparation; by adopting intramuscular injection for drug administration, the in vivo acting time of the drug can be significantly prolonged, the times of drug administration are reduced and the blood concentration of diseased livestock can keep stable. The new veterinary medicine preparation of the invention is safe, stable, effective and controllable in quality, thus being widely applicable to the treatment of bacterial infection and parasitic infestation in livestock.

The invention discloses an external medicine for treating autoimmune dermatosis and a preparation method and application thereof. The main ingredient of the external medicine is a NK cell stock solution, wherein the NK cell stock solution is obtained by performing multiplication culture on NK cells, the NK cell stock solution is mixed with different drug excipients, and an external liquid preparation or an external paste preparation can be prepared. Compared with the prior art, the external medicine contains anti-inflammatory and high-efficiency active factors, the active ingredients of the medicine can safely and effectively reach the lesions so as to eliminate the pathogenesis, and the effects of rapidly relieving pain and relieving symptoms can be achieved. After the medicine is used, a skin protection film can be formed, and injury repair is facilitated. The medicine has excellent effects on autoimmune dermatosis such as psoriasis, pityriasis rosea, erythema multiforme and the like, is convenient to use, does not have any toxic or side effect due to long-term use, and is also applicable to special crowds who are unsuitable to use other types of medicines and hormones, particularly people with skin allergy, infants, pregnant women and the like.

The invention relates to a composition having effects of whitening, removing spots and refreshing skin. The composition is obtained by uniformly mixing powder of ginkgetin extracted from ginkgo leaves, powder of sesamin extracted from sesame seed meal and powder of astragalosides extracted from radix astragali according to a mass ratio of (1-10): (1-10): (1-10). The composition and make-up preparations or drug excipients can be mixed into an external skin preparation such as cream, an emulsion, gel, paste and a subcutaneous injection. A pharmacological test research shows that the composition has effects of inhibiting skin tyrosinase activity and melanin generation. A clinical trial shows that the composition has obvious whitening, spot-removal and skin-refreshing effects on people having a medium yellow facial color and facial color spots, has an effective rate of 100%, is safe and has no side-effect.

The present invention discloses manidipine hydrochloride tablets and a preparation method thereof, wherein manidipine hydrochloride is adopted as the active component, an effective amount of colloidal silica is adopted as the drug excipient for improving the dissolution rate, and riboflavin for improving the stability is adopted as the stabilizer. According to the present invention, the light instability and the insolubility of the manidipine hydrochloride are overcome so as to improve the stability and the dissolution rate of the manidipine hydrochloride tablets.

The invention discloses a preparation method of Sihuang heart-clearing concentrated pills, and solves the problems that Sihuang heart-clearing concentrated pills in the prior art cannot be suitable for diabetic patients because honey is used as an adhesive in a preparation method of the Sihuang heart-clearing concentrated pills and effective ingredients are released slowly and the bioavailabilityis low because raw drug powder is used for preparation. The concentrated pills are prepared by extracting and concentrating a part of medicinal materials in a prescription and adding the remaining part of medicinal powder through a plastic molding or generic processing method. The method no longer uses honey as a drug excipient, so that the medicine increases the applicable population; meanwhile,the release speed and the bioavailability of the concentrated pills are obviously higher than those of large honey pills in the prior art.

The present application relates generally to novel pharmaceutical drug formulations comprising modified chemical compositions having reduced capacity for excipient mediated cross reactivity. Methods for their use and methods for identifying excipient related incompatibilities and / or adverse events are also disclosed.

The invention discloses application of kukoamine in preparing medicine for treating type II diabetes mellitus and belongs to the field of Chinese medicine chemistry. The kukoamine can further realize a hypoglycemic effect by restraining activity of dipeptidyl peptidase4 (DPP-4), so that the kukoamine can be applied to preparing medicine for treating diabetes mellitus. The invention further provides a pharmaceutical composition containing the kukoamine serving as an effective ingredient and drug excipient or carrier which is acceptable in pharmaceutics, and the pharmaceutical composition with the kukoamine as the effective ingredient can effectively improve insulin to resist glucose consumption level of cells and provides novel medicine choice for preventing and treating diabetes mellitus.

The invention discloses hydroxytyrosol eye drops for effectively targeting trigeminal ganglion and a preparation method thereof. The eye drops comprise hydroxytyrosol used as a main drug and a preservative, an isoosmotic adjusting agent, a polyethylenecaprolactam-polyvinyl acetate-polyethylene glycol copolymer and lidocaine or its pharmaceutically acceptable salts. Mass ratio of the hydroxytyrosol main drug to the polyethylenecaprolactam-polyvinyl acetate-polyethylene glycol copolymer drug excipient is 1: 18. Mass ratio of lidocaine to the polyethylenecaprolactam-polyvinyl acetate-polyethylene glycol copolymer drug excipient is 1: 18-1: 90. The eye drops of the invention have good solubility and stability, and micelles have controllable particle size, uniform distribution range and good storage stability. Through ocular surface administration, the eye drops effectively target and are absorbed by trigeminal ganglion, thus raising safety and effectiveness of the medicine in treating diabetic keratopathy and nervous lesion.

The invention belongs to the field of starch modification and application, and discloses a drug excipient prepared through the synergistic effects of chemical modification and enzymolysis on starch. The preparation method comprises the following steps: at first, adding sodium trimetaphosphate into the starch for reaction under the alkaline condition, regulating the obtained product to be neutral, and obtaining crosslinked starch after pumping washing and washing; then, preparing the crosslinked starch into crosslinked starch milk by using an acetic acid-sodium acetate buffer solution, adding beta-amylase into the crosslinked starch milk after high-temperature gelatinization for enzymatic hydrolysis, and performing high-temperature enzyme deactivation, alcohol dissolution, centrifuging, drying, crushing and screening to obtain solid powder which is the drug excipient. The drug excipient overcomes the defects of native starch and single modified starch, and the quantity of the other matters added in tablets as auxiliary materials is minimized, so that the drug preparation cost can be lowered, side effects of the drug are reduced, and the drug effect can be improved.

The invention discloses a method for preparing nano cellulose by simultaneous assistance of ultrasonic waves and microwaves, belonging to the field of biomass nano materials. According to the nano material, liquid acid is taken as a catalyst, and the high-efficiency hydrolysis at the amorphous area of cellulose is promoted due to the simultaneous assistance of the ultrasonic waves and microwaves, so that the nano cellulose is rapidly prepared by plant fiber raw materials. The preparation method comprises the steps of acid hydrolysis of plant cellulose, centrifugal recovery of liquid acid and centrifugal separation of nano cellulose. According to the method, the mechanical dispersion action and ultrasonic cavitation effect of the ultrasonic waves, microwave uniform heating effect, catalytic action of the liquid acid and the synergistic effect of the ultrasonic waves and microwaves are utilized sufficiently, and the hydrolytic process of cellulose is enhanced, so that the high-efficiency and rapid preparation of the nano cellulose can be realized. The prepared nano cellulose material can be used for food additives, drug excipients, engineering material additives, specialty paper additives and the like.

The invention relates to an antibody-modified anti-tumor targeted drug delivery and combined therapy system and a preparation method and application thereof, the system is composed of black phosphorus, polydimethyldiguanide and an anti-PD-L1 antibody, the polydimethyldiguanide wraps the surface of a black phosphorus nanosheet to form a nanocomposite, and then the anti-PD-L1 antibody is adsorbed on the surface of the nanocomposite. The black phosphorus, the polydimethyldiguanide and the anti-PD-L1 antibody used in the invention not only show the antitumor drug properties with excellent curative effects in the aspects of photothermal therapy, chemotherapy and immunotherapy, but also have the properties of carrying drugs, stabilizing drug carriers and endowing a nano drug delivery system with tumor tissue targeting, and have excellent application prospects in the field of drug excipients. In addition, the anti-tumor nano drug delivery and combined treatment system constructed by the invention cooperates with photothermal therapy, chemotherapy and immunotherapy, effectively improves the anti-tumor performance, fully avoids the potential problem of independent application of each treatment means, and excellently embodies three-in-one.

The invention provides a Chinese medicinal herb for treating a tristimania and preparation method thereof. The Chinese medicinal herb is prepared to an oral preparation by the following steps of: taking Ghananian grains, hypericum perforatum, angelica sinensis, hawthorn, radix curcumae, acanthopanax senticosus, ligusticum wallichii and rehmannia as raw materials, extracting and concentrating the raw materials and adding a proper amount of drug excipient. According to the principle of the Chinese medicinal herbs, the Chinese medicinal herb disclosed by the invention is screened through tests for many years. The raw material drugs in a prescription are selected, the preparation process is optimized, and the Chinese medicinal herb disclosed by the invention has obvious restraining, remission and treatment effects on the depressive symptoms of a patient suffering from tristimania without any side effect.

The invention relates to a solid medicine composition containing dronedarone. The solid medicine composition containing dronedarone is characterized by containing the dronedarone for resisting arrhythmia or pharmacal acceptable salt serving as one active ingredient, and pharmacal acceptable polyhydroxy-alcohol. The solid medicine composition can be combined with one or more drug excipient.

The invention discloses an externally used traditional Chinese medicine for treating male infertility with kidney deficiency and blood stasis type oligospermia and a preparation method of the externally used traditional Chinese medicine and aims to solve the technical problems of infertility caused by oligospermia and asthenospermia of males. The externally used traditional Chinese medicine comprises raw medicinal materials in parts by weight as follows: 20-40 parts of rhizoma polygonati, 20-33 parts of semen cuscutae, 10-26 parts of herba epimedii, 25-40 parts of radix astragali, 2-10 parts of flos caryophyllata, 6-13 parts of flos carthami, 1-8 parts of resina draconis, 10-26 parts of radix angelicae sinensis, 10-20 parts of radix salviae miltiorrhizae and 5-17 parts of radix achyranthisbidentatae. The raw materials are ground into powder and mixed uniformly and then mixed with an appropriate quantity of a drug excipient, and a mixture is blended into paste. With adoption the pure traditional Chinese medicine raw materials, sperm quality of the males is fundamentally improved, the number of sperms in seminal fluid is increased, sperm activity is improved, pregnancy rate of matesis greatly increased, and the problem of poor treatment effect of existing medicines for treating male infertility is solved effectively.