Antiviral influenza drug and preparation method thereof

An anti-virus and drug technology, applied in anti-viral agents, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large loss of active ingredients, instability of medicinal substances, and large impact on clinical efficacy, and achieve drug quality assurance and quality standards Controllable, highly effective results

Inactive Publication Date: 2012-08-15
东莞市沙田医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to literature reports, Daqinglong Decoction has the effect of treating colds with wind-cold exterior excess and stagnant heat syndrome; Daqinglong Decoction dissolves the exterior and clears the interior, and its sweating power is stronger than that of Mahuang Decoction. It is used in modern clinical practice to treat obvious anhidrosis of the exterior and concurrent interior Those who are hot; its medicinal effect is fierce and difficult to control moderately, so the application of Daqinglong Decoction is still in the form of prescriptions prescribed by doctors according to the patient's condition, and there are few reports about its use in clinical large-scale observation
[0004] In addition, traditional Chinese medicine decoctions mostly use traditional decoctions, and factors such as the amount of water added, the number of decoctions, and decoction time have a great impact on the clinical efficacy. At the same time, traditional Chinese medicine decoction also has disadvantages such as large dosage and inconvenient carrying.

Method used

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  • Antiviral influenza drug and preparation method thereof
  • Antiviral influenza drug and preparation method thereof
  • Antiviral influenza drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]An antiviral influenza medicine comprises the following substances: 10g of ephedra, 10g of cassia twig, 6g of roasted licorice, 10g of bitter almond, 10g of ginger, 20g of jujube, and 20g of gypsum.

[0037] Preparation:

[0038] First, add 10g of Guizhi ginger to 8 times of water, without soaking, extract by steam distillation for 6 hours, collect volatile oil and medicinal liquid for later use;

[0039] Then, mix the medicinal residue after extracting the volatile oil and the medicinal liquid with the rest of the medicinal materials, add 10 times of water, extract 3 times by steam distillation, and extract for 1.5 hours each time, filter the extracted medicinal liquid and combine it with the spare medicinal liquid, and let it stand , filter; the filtrate is concentrated to a relative density between 1.1 and 1.2, and spray-dried (drying conditions are air inlet temperature 175°C, air outlet temperature 90°C, atomizing disk speed 20000 rpm), to obtain the antiviral extr...

Embodiment 2

[0042] An antiviral influenza medicine comprises the following substances: 8g of ephedra, 8g of cassia twig, 5g of roasted licorice, 8g of bitter almond, 8g of ginger, 18g of jujube, and 18g of gypsum.

[0043] Preparation

[0044] First, add 8g of Guizhi ginger to 4 times of water, soak for 1 hour, extract by steam distillation for 4 hours, collect volatile oil and medicinal liquid for later use;

[0045] Next, mix the medicinal residue after extracting the volatile oil and the medicinal liquid with the rest of the medicinal materials, add 8 times of water, extract twice by steam distillation, and extract for 2 hours each time, filter the extracted medicinal liquid and combine it with the spare medicinal liquid, and statically place and filter; the filtrate is concentrated to a relative density between 1.14 and 1.18, and spray-dried (drying conditions are air inlet temperature 170°C, air outlet temperature 85°C, atomizing disk speed 20000 rpm), to obtain the anti Extracts of...

Embodiment 3

[0048] An antiviral influenza medicine comprises the following substances: 12g of ephedra, 12g of cassia twig, 7g of roasted licorice, 12g of bitter almond, 12g of ginger, 22g of jujube, and 22g of gypsum.

[0049] Preparation

[0050] First, add 6 times of water to cassia twig and ginger, soak for 2 hours, and extract for 2 hours to obtain volatile oil and medicinal liquid for later use;

[0051] Then mix the remaining medicinal residues with the remaining medicinal materials, add 12 times of water, extract once by steam distillation, extract for 1 hour, filter to obtain the extracted medicinal liquid and merge the standby medicinal liquid, let stand, filter; the filtrate is concentrated to a relative The density is between 1.14 and 1.15, and the extract of the antiviral influenza drug is obtained through spray drying (drying conditions are air inlet temperature 180°C, air outlet temperature 95°C, atomization disc rotation speed 20000 rpm);

[0052] Finally, the extract of t...

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PUM

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Abstract

The invention relates to an antiviral influenza drug and a preparation method of the antiviral influenza drug. The drug comprises the following ingredient by weight: 8-12 parts of ephedra, 8-12 parts of cassia twig, 5-7 parts of processed licorice root, 8-12 parts of semen armeniacae amarae, 8-12 parts of ginger, 18-22 parts of Chinese-date and 18-22 parts of gypsum. The preparation method comprises the steps of soaking the cassia twig and the ginger, extracting to obtain volatile oil and liquid medicine for standby application; then mixing the drug dregs and other crude drugs, extracting to obtain liquid medicine, mixing the liquid medicines obtained from the above two steps, then concentrating, spraying and drying to obtain a drug extract; and finally, mixing the extract with a pharmaceutically acceptable carrier or a drug excipient according to proportion, pelletizing and drying, and adding the standby volatile oil to prepare the antiviral influenza drug. The antiviral influenza drug has obvious curative effect, can be used in large range, and is convenient to take, accurate in curative effect, controllable in quality, simple in manufacturing process flow, controllable in quality standard, energy-saving in energy resources, free from environment pollution, small in potential safety hazard, and suitable for industrial production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an antiviral influenza medicine and a preparation method thereof. Background technique [0002] The classic Fang Daqinglong Decoction in "Treatise on Febrile Diseases" created by the medical sage Zhang Zhongjing is composed of seven flavors: ephedra, cinnamon sticks, licorice, ginger, jujube, almonds, and gypsum. , those who are irritable without sweating, the master of Daqinglong soup." This prescription is clinically used for severe syndromes of external cold. Because cold evils are bound externally, external evils are suppressed, evils and positives compete with each other, and positives cannot be stretched, it can be seen in various symptoms; The five elements of cold belong to water, sweetness belongs to earth, and earth is better than water, so sweetness is used to cure cold; water and cold are similar, the pungent sweetness of gypsum and the pungent warmth of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P31/16A61K33/06
Inventor 周爱军刘焱文陈婕
Owner 东莞市沙田医院
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