Anti-cancer drug prepared by using 3D printing technology, and method

An anti-cancer drug, 3D printing technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of complex, slow-release properties without any special outstanding performance, single appearance, etc., and achieve good therapeutic effects. and experience, simple operation, and the effect of improving utilization

Inactive Publication Date: 2016-11-16
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

At present, the chemical drugs, biological drugs, and Chinese patent medicine preparations used in hospitals are all mass-produced, with a single shape, and there is no outstanding performance in terms of compounding and sustained release.
Patent 201610053263.8 describes a method for preparing drug particles with a specific formula through 3D printing technology using drug powder and a specific binder. The 3D printing technology of the technology has great limitations in the preparation of sustained-release structures and the preparation of compound drugs of different materials (such as dual nozzles, or even multi-nozzles for composite printing of different materials to prepare drugs), so it needs to be used. 3D printing technology based on fused accumulation modeling to further supplement and improve this method

Method used

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  • Anti-cancer drug prepared by using 3D printing technology, and method

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Experimental program
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Effect test

Embodiment 1

[0046] A 3D printed anticancer drug, the preparation process is as follows:

[0047] (1) Using computer-aided design special software (AutoCAD3DMax2015), design a drug particle model with an elliptical multilayer structure ( figure 1 A), the volume is 310mm 3 .Save this model as an STL format file, process it with layering software (ezlayout_reg1.26), and finally process it to get the most suitable file for printing, and import it into a 3D printer (Tianwei 3D printer CoLiDo X3045).

[0048] (2) 2.5g doxorubicin (manufactured by Wuhan Dahua Weiye Pharmaceutical Chemical (Group) Co., Ltd., melting point 205°C) drug crystal powder and 250g dried polyvinyl alcohol granules (Shanghai Emma Biotechnology Co., Ltd., SIGMA model) ) and 0.25g auxiliary material γ-polybenzyl glutamate were mixed uniformly, placed in the mixer and set at 100rpm to run for 15 minutes; the uniformly mixed material was put into the SJ single-screw plastic extruder, and the The temperature setting is: 170°...

Embodiment 2

[0052] (1) Using computer-aided design special software (AutoCAD3DMax2015), design a drug particle model with an elliptical inner and outer double-layer structure ( figure 1 -B model), the volume is 310mm 3 . Save this model as an STL format file, process it with layering software (ezlayout_reg1.26), and finally process it to get the most suitable file for printing, and import it into a 3D printer (CoLiDo X3045, a 3D printer from Tianwei Company).

[0053] (2) 12.55g paclitaxel (produced by Guangzhou Aichun Pharmaceutical Technology Co., Ltd., melting point 213°C) drug crystal powder was mixed with 250g dried polyvinyl alcohol polymer particles and 0.25g adjuvant gamma-polybenzyl glutamate, Set the mixer to run at 100rpm for 10 minutes; put the uniformly mixed material into the SJ single-screw plastic extruder, and set the temperature of the single-screw plastic extruder to: 170°C in the first zone of the machine head and 180 in the first zone of the barrel ℃, 178℃ in the se...

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Abstract

The invention discloses an anti-cancer drug prepared by using a 3D printing technology, and a method. The method comprises: uniformly mixing an anti-cancer drug, a high polymer material, and a drug excipient, extruding obtained mixture through an extruding machine, to obtain a wire rod containing drug; using computer design software to design a structure model of the anti-cancer drug, storing the structure model in a file format which can be identified by a 3D printer, importing the file into the 3D printer, using hierarchical software to perform hierarchical processing; respectively importing the high polymer material and the obtained wire rod containing drug into the 3D printer, selecting the drug structure model, setting printing precision, velocity, and temperature, to obtain the 3D printed anti-cancer drug. The method is characterized in that the method is convenient and fast and is simple in operation, and the size and shape of a tablet can be designed according to variation of weather and climate. The method can make tablets in different sizes and shapes, and utilization rate of the drug can be effectively improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of anticancer drugs, and in particular relates to an anticancer drug prepared by 3D printing technology and a method thereof. Background technique [0002] 3D printing technology is a rapid prototyping technology that is gradually becoming popular at present. It is a green desktop rapid prototyping technology. The printing method completes the structure and formation of the object pair. Thermoplastic filamentary polymer materials are continuously extruded in a molten state, and then solidified to form contoured thin layers, which are stacked layer by layer to finally form products, which can be stacked layer by layer under precise positioning to build various three-dimensional objects. 3D printing technology has great application prospects in the field of biomedicine. Its rapidity, accuracy, and characteristics of being good at making complex shapes and color entities make it have a very wide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00A61K9/50A61K45/00A61K31/704A61K31/337A61K47/34A61P35/00
CPCA61J3/00A61K9/5031A61K31/337A61K31/704A61K45/00
Inventor 周武艺胡洋董先明屈阳麦卓贤曹庆云
Owner SOUTH CHINA AGRI UNIV
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