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External medicine for treating autoimmune dermatosis and preparation method and application thereof

An autoimmune, external drug technology, applied in the field of external drug for treating autoimmune skin diseases and its preparation, can solve the problems of inability to cure, large toxic and side effects, single effect, etc., and achieves convenient use, clearing the cause, and being non-toxic. Effects of side effects

Inactive Publication Date: 2017-01-25
SHANGHAI MINGDA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies of the prior art, and provide a kind of external medicine for treating autoimmune skin diseases and its preparation method and application, so as to solve the problem that the existing medicine has single action, unsatisfactory curative effect, and some skin diseases repeatedly Onset, unable to cure, and technical problems such as large toxic and side effects

Method used

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  • External medicine for treating autoimmune dermatosis and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] 1. Materials:

[0028] The methods used in this example are conventional methods known to those skilled in the art unless otherwise specified, and the reagents and other materials used are all commercially available products unless otherwise specified.

[0029] 2. Method

[0030] 2.1 Preparation of NK cell stock solution

[0031] Step 1: PBMC extraction:

[0032] Centrifuge the fresh blood at 740g for 10 minutes to obtain the upper layer of light yellow plasma and the lower layer of blood cells, mix the lower layer of blood cells with normal saline at a volume ratio of 1:1, take a 50ml centrifuge tube, and spread the diluted blood cell suspension on 15ml of lymphocyte separation medium Centrifuge at 400g for 30 minutes. Collect the white membranous cell layer in the middle, add physiological saline to wash, centrifuge at 400g for 10 minutes, discard the supernatant, and repeat the washing once. Finally, the cell pellet was resuspended with an appropriate amount of c...

Embodiment 2

[0064] This embodiment provides a SNK liquid, which is composed of NK cell stock solution 80.0%, glycerin 2.0%, borax 0.08%, ethylparaben 0.03% and appropriate amount of sterile water by weight.

[0065] Select 2 cases of psoriasis patients, treat with the above-mentioned SNK solution, use it 2-3 times a day, after 20 days of continuous use, the symptoms are obviously relieved, and after 25 days of use, they are basically fully recovered, which has a significant therapeutic effect.

Embodiment 3

[0067] The present embodiment provides a kind of SNK paste, by weight, described SNK paste is composed of NK cell stoste 65.0%, white petrolatum 10.0%, mono- and distearin 10.0%, ethyl p-hydroxybenzoate 0.5%, It consists of 0.5% borax, 5.0% dimethyl sulfoxide, 10.0% sorbic acid and appropriate amount of sterile water.

[0068] Select 3 cases of patients with erythema multiforme, use the above-mentioned SNK ointment for treatment, 2-3 times a day, after 2 weeks of continuous treatment, the mild patients basically recovered, and the symptoms of severe patients improved significantly.

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Abstract

The invention discloses an external medicine for treating autoimmune dermatosis and a preparation method and application thereof. The main ingredient of the external medicine is a NK cell stock solution, wherein the NK cell stock solution is obtained by performing multiplication culture on NK cells, the NK cell stock solution is mixed with different drug excipients, and an external liquid preparation or an external paste preparation can be prepared. Compared with the prior art, the external medicine contains anti-inflammatory and high-efficiency active factors, the active ingredients of the medicine can safely and effectively reach the lesions so as to eliminate the pathogenesis, and the effects of rapidly relieving pain and relieving symptoms can be achieved. After the medicine is used, a skin protection film can be formed, and injury repair is facilitated. The medicine has excellent effects on autoimmune dermatosis such as psoriasis, pityriasis rosea, erythema multiforme and the like, is convenient to use, does not have any toxic or side effect due to long-term use, and is also applicable to special crowds who are unsuitable to use other types of medicines and hormones, particularly people with skin allergy, infants, pregnant women and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an externally applied medicine for treating autoimmune skin diseases, a preparation method and application thereof. Background technique [0002] Psoriasis is a common chronic skin disease, also known as psoriasis. It is characterized by pimples and erythema of various sizes, covered with white scales on the surface, with clear boundaries, and occurs on the scalp, extensor sides of the extremities and the back. It is easy to recur or aggravate in spring and winter, and it is more relieved in summer and autumn. At present, the disease cannot be completely cured, and the treatment methods used may only have the effect of controlling the disease. [0003] Pityriasis rosea is a common inflammatory skin disease that occurs on the trunk and proximal extremities of varying sizes and indefinite number of rose-colored patches with sugar-like scales on them. The disease is self-limiting an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61P37/02A61P17/00A61P17/06A61P17/04A61P29/00C12N5/0783
Inventor 卢玲琳王驹王苏鸣
Owner SHANGHAI MINGDA BIOTECH CO LTD
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