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Carbostyrile antibiotic injection preparations

A technology of quinolones and injection preparations, applied in the directions of antibacterial drugs, drug delivery, powder delivery, etc., can solve problems such as application limitations, and achieve the effects of good antibacterial effect, strong antibacterial effect, and broad antibacterial spectrum

Inactive Publication Date: 2007-12-05
严明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the increasingly widespread use of fluoroquinolones, certain bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa have developed resistance to existing species headed by ciprofloxacin
In addition, some quinolone varieties have relatively serious side effects, so the clinical application of earlier second-generation or even third-generation quinolone antibiotics has begun to be limited

Method used

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  • Carbostyrile antibiotic injection preparations
  • Carbostyrile antibiotic injection preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Make the concentrated solution that is made into solution before use with the raw and auxiliary materials of the following weight ratio:

[0021] Quinolones

Embodiment 2

[0023] Make the concentrated solution that is made into solution before use with the raw and auxiliary materials of the following weight ratio:

[0024] Quinolones

0.1mol / L hydrochloric acid

51.0g (102% feed)

Appropriate amount

Add water for injection to 1000ml, pack into 125 sticks, 10ml each stick, each stick contains main

Medicine 400mg

[0025] The above example sample preparation process is as follows:

[0026] 1. Dosing: Take quinolone antibiotics according to the weight ratio, add water for injection (about 60°C) to the full amount, stir to dissolve, and adjust the pH to about 4.0 with 0.1mol / L hydrochloric acid. Add 0.2% activated carbon, keep stirring for 20 minutes. 0.45 μm microporous membrane to remove activated carbon, take the crude filtrate, measure the pH value of the solution and pass the content, then pass the crude filtrate through a microporous membrane with a pore size of 0.22 μm for fine filtration.

[0027] 2. Fillin...

Embodiment 3

[0031] The sterilizing solution for injection into the body is made with the raw and auxiliary materials in the following weight ratio:

[0032] Quinolones

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Abstract

The present invention provides one kind of quinolone antibiotic injection, which contains quinolone as antibiotic, its salt or their hydrate, and may be prepared into instant injection, concentrated solution for compounding injection or freeze dried powder for compounding injection. Quinolone antibiotic has phamacodynamic activity similar to that of levofloxacin, and possesses broad antibiotic spectrum, less toxic side effect and other advantages. The quinolone antibiotic injection is effective, safe and reliable.

Description

technical field [0001] The invention relates to an injection preparation of quinolone antibiotics. Background technique [0002] Since the first quinolone synthetic antibiotics came into the market in the 1960s, such drugs have been developed rapidly. However, with the increasingly widespread use of fluoroquinolones, certain bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa have developed resistance to existing varieties led by ciprofloxacin. In addition, some quinolones have serious side effects. Therefore, the clinical application of earlier second-generation or even third-generation quinolone antibiotics has begun to be limited. Contents of the invention [0003] In order to solve the above problems, the present invention provides an injection preparation of quinolone antibiotics obtained by adding amino groups based on levofloxacin. [0004] In order to make the quinolone antibiotics into injection preparations convenient for clinical use, the present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K31/5383A61P31/04
Inventor 严明
Owner 严明
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