Oral proliposome containing atorvastatin calcium and preparation method of oral proliposome

Abstract

The invention relates to an oral proliposome containing atorvastatin calcium and a preparation method of the oral proliposome. The oral proliposome comprises the following components: 0.5%-10% of the atorvastatin calcium, 10%-30% of phospholipid, 2%-10% of poloxamer, 50%-87.3% of absolute ethanol and 0.2%-3% of a stabilizer. The preparation method comprises the following steps: adding the atorvastatin calcium, the phospholipid, the poloxamer and the stabilizer into the absolute ethanol solvent, mixing in the absence of water, and dissolving the mixture into a clear anhydrous solution so as to obtain an atorvastatin calcium proliposome preparation. The proliposome can be quickly self-assembled into the medicated proliposome preparation with a proper particle size and high encapsulation efficiency after being diluted by a proper hydration medium before use and is used for oral administration, the operation is easy and convenient, and the oral administration mode can be easily accepted by patients.

Description

technical field [0001] The invention relates to an oral proliposome containing atorvastatin calcium and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer of human death, and 10 million people worldwide die of cardiovascular diseases every year, and dyslipidemia is the main cause of cardiovascular and cerebrovascular diseases. Therefore, one of the basic methods to effectively prevent and treat cardiovascular and cerebrovascular diseases is to adjust the abnormal blood lipid level of the human body. At present, the most widely used lipid-lowering drugs in clinical practice are statins. A blood lipid revolution triggered by "statins" is emerging around the world. Lipid-lowering therapy will become the main method for preventing cardiovascular diseases in the 21st century. [0003] Among them, atorvastatin calcium is the most effectiv...

AI Technical Summary

Problems solved by technology

Patent Publication No. CN101804029A discloses an atorvastatin liposome, which is composed of atorvastatin or a pharmaceutically acceptable salt plus an alkalizing agent with a pH greater than 5, and phospholipids, but the preparation has poor bioavailability and cannot effectively Exercising the pharmacological activity of atorvastatin

[0007] At present, liposomes are mostly used for injection administration, but a large amount of organic solvents must be added as solvents for intravenous administration, which limits the clinical application of drugs and causes pain and inconvenience to patients.

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