The invention provides a centralized supervision device and a supervision method of 
USB interface equipment networking. In the invention, based on a network 
client side / 
server model, an MCU 
chip of Cyan company is adopted to realize an embedded 
USB interface equipment storage device with network 
client side function, and a Winsock 
programming technology is adopted to realize network 
server function on a supervision center. According to the 
USB, MSC and CBI protocol, the 
unique identifier of the USB interface equipment is constructed; a 
concentrator receiving and transmitting device is used forexpanding a USB interface slot; and the embedded USB interface equipment storage device is used for acquiring and indentifying the 
unique identifier and status information of the USB interface equipment on every USB slot, and transmitting the 
unique identifier and the status information to the remote monitoring center by 
Ethernet. The remote monitoring center leads the lending and return of the USB equipment to be always kept under effect supervision, and carries out alarming and gives out notice according to alarm rules. The centralized supervision device of USB interface equipment networking has small volume, convenient installation, good reliability and strong 
confidentiality, and can realize the 
centralized management to the USB interface equipment by the network.