The invention discloses a vehicle anti-theft system and method of a parking lot. A first camera collects entry data of vehicles, a second camera collects exit data of the vehicles, a third camera collects parking and departure data of the vehicles, the cameras transmit corresponding data to a server via a router in a WLAN communication protocol transmission manner, the server extracts and stores license plate numbers, vehicle owner/driver head portraits and vehicle driving features of the vehicles as basis information for monitoring examination, whether a vehicle has a risk of being stolen is detected in real time, and if YES, the server notifies the vehicle owner and a parking lot manager for confirmation timely, and the vehicle is not released unless both the vehicle owner and the parking lot manager confirm there is no risk. Compared with the prior art, the system and method can overcome management vulnerability of vehicle monitoring, reduces the risk of being stolen of the vehicles, and the vehicle anti-theft system is safer and more reliable.