The invention relates to a six-DOF (
degrees of freedom) three-dimensional-manipulation 
robot. The six-DOF three-dimensional-manipulation 
robot comprises a pedestal bearing, a horizontal sliding table, a vertical moving arm, an upper arm lever, a 
forearm lever, a swing 
flange and an output shaft; the pedestal bearing consists of vertical upright columns and horizontal crossbeams supported on the upright columns; the horizontal sliding table is arranged on the crossbeams and does 
horizontal translation through 
pinion and rack transmission, so as to form a horizontal movement degree of freedom; the vertical moving arm is connected with the horizontal sliding table and does vertical movement through 
pinion and rack transmission, so as to form a vertical movement degree of freedom; the upper arm lever is connected to the lower end of the vertical moving arm and does rotational movement, so as to form a first rotational degree of freedom; the 
forearm lever is connected to the front end of the upper arm lever and does rotational movement, so as to form a second rotational degree of freedom; the swing 
flange is connected to the front end of the 
forearm lever and does rotational movement, so as to form a third rotational degree of freedom; the output shaft is connected to the side end of the swing 
flange and does rotational movement, so as to form a fourth rotational degree of freedom; the output shaft achieves operation of a predetermined trajectory in a three-dimensional space through the combined action of the 
six degrees of freedom. The six-DOF three-dimensional-manipulation 
robot has the advantages of simple structure, high reliability, large 
working space and the like.